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R Abascal García

Publications and source records attributed to R Abascal García.

8 recordsLinked to original sources
PubMed2001

[Proteases and prostatic disease: cytosolic cathepsin D].

OBJECTIVE: Cytosolic cathepsin D is a recognized predictor in breast cancer. This study was conducted to determine its behaviour in benign prostatic hyperplasia (BPH) and prostate cancer. The changes according to prostate volume, its relation with other serum markers (PSA, PAP, etc.) in regard to tumor grade, stage and survival were analyzed. METHODS: The study was carried out on 376 patients with prostatic disease that had been diagnosed from 1991-1996. Determination of cytosolic cathepsin D levels was performed on all samples of prostate tissue according to the CIS BioInternational Immunoradiometric study. RESULTS: Cathepsin D values ranged from 0.2 to 86.5 pmol/mg (mean 14.9) in patients with BPH and higher values were found for prostates with a larger volume (p = 0.004). A significant difference was found between patients with and those without a bladder catheter (p = 0.024); values were higher in the former group of patients. Cathepsin D values ranged from 0.5 to 74 pmol/mg (mean 18.13) in patients with prostate cancer. A statistically significant difference was found between the mean values of patients with prostate cancer and those with BPH (p = 0.047). In patients with prostate cancer, a significant difference was also found between patients with and those without a catheter (p = 0.04). No relationship was found between cathepsin D and the other parameters analyzed. CONCLUSIONS: As in most of the literature reviewed, cytosolic cathepsin D was not found to be a predictor in prostate cancer. Furthermore, no correlation was found between cathepsin D and the other markers analyzed. The foregoing may be due to the small number of tumor samples and short follow-up.

Adult↗
PubMed1999

[Artificial sphincter implantation in women with urinary incontinence using a combined abdomino-vaginal approach].

OBJECTIVE: The artificial sphincter has been utilized for urinary incontinence due to intrinsic sphincteric insufficiency, with good fixation of the urethra and a maximum urethral closing pressure of 20-30 cms H2O, or after failed attempts at correction using other techniques. This procedure is difficult to perform since the patients have generally undergone several operations and it is necessity to prepare the cleavage between the urethra and vagina. We propose a modified combined vaginal and suprapubic approach of the technique described by Appell and Abbassian in 1988 for enhanced exposure of the urethra and bladder neck and easy access. METHODS: The modified combined abdominovaginal approach has been utilized in 18 females aged 16-62 years since 1995. RESULTS: 16 patients were continent (88%). One patient (5.5%) required removal of the artificial sphincter due to infection. Another patient (5.5%) has mild incontinence and requires 2 pads a day. Four patients (22%) with detrusor instability are receiving anticholinergics. Three patients (16%) with an underlying neurogenic incontinence require intermittent catheterization. Fourteen patients (77.7%) have type III stress urinary incontinence. We performed the Kelly procedure in 10 patients (55.5%), the Marshall-Marcetti-Kranz in 7 (38.8%), Gittes in 3 (16.6%), and 2 patients (11.1%) had a sling procedure. Two techniques were simultaneously performed in some patients. CONCLUSIONS: Although the number of patients in this series is small, the fact that only one case required removal of the artificial spincter due to infection indicates that this is a useful alternative approach that significantly facilitates implantation of the artificial sphincter in these patients.

Abdomen↗
PubMed1994

[Urethral protrusion caused by blunt trauma of the anterior urethra].

We report an uncommon case of complete rupture of the anterior urethra secondary to blunt trauma, with protrusion of the urethral mucosa through the urinary meatus. The singular images of this case are presented and the mechanisms involved in this unusual type of lesion are analyzed.

Humans↗
PubMed1988

Granulomatous prostatitis.

Twenty cases of granulomatous prostatitis are presented. They were identified, histologically or cytologically, among 1,316 patients with prostatic pathology at the General Hospital of Asturias during a period of 3 years (Jan. 1984 to Dec. 1986). The etiology, histogenesis, clinical and morphological aspects, treatment and prognosis of the different types of granulomatous prostatitis, according to a classification by the authors, are discussed. The significance of the differentiation of granulomatous prostatitis from carcinoma is discussed. Fine-needle aspiration cytology (Franzen) is recommended as the diagnostic method of choice.

Biopsy, Needle↗
PubMedDate not supplied

[Ultrasonographic diagnosis of Fournier's gangrene].

OBJECTIVES: The usefulness of ultrasound in the detection of Fournier's gangrene in the early stages is described herein. METHODS/RESULTS: We discuss the clinical course of the patient with scrotal inflammation of a torpid course suspected as Fournier's gangrene on the ultrasound findings. CONCLUSIONS: The use of ultrasound in cases with acute scrotal inflammation of a torpid course as in this case, permits early detection of Fournier's gangrene, a fulminant condition. A review of the literature has shown that the findings described herein have been infrequently reported.

Gangrene↗