Asynchronous burst suppression.
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Cerebral Hemorrhage↗
Biomedical subjects
R A Wennberg
Publications and source records attributed to R A Wennberg.
Central nystagmus induced by deep-brain stimulation for epilepsy.
PURPOSE: The goal of the present study was to describe the localization of central nystagmus induced as a side effect of electrical deep-brain stimulation for epilepsy. METHODS: Bilateral deep-brain stimulating electrodes were inserted in the centromedian nucleus of the thalamus to control seizures in a patient with intractable epilepsy. RESULTS: Cathodal high-frequency stimulation through the deepest contact of each electrode elicited cycles of slow ipsiversive conjugate eye deviations, each followed by rapid contralateral jerks. The involved electrode contacts were situated at the mesodiencephalic junction just inferior to the centromedian nucleus of the thalamus and rostral to the superior colliculus. Right-sided stimulation evoked left beating nystagmus and left-sided stimulation evoked right beating nystagmus. Stimulation through other electrode contacts did not induce nystagmus. Electronystagmography showed the nystagmus to have constant velocity slow phases. CONCLUSIONS: A central nystagmogenic area exists in humans that appears to be homologous to the nucleus of the optic tract, a region described in nonhuman primates to play a role in the generation of optokinetic nystagmus.
Adult↗
Poor surgical outcome in patients with neocortical epilepsy is correlated with interictal epileptiform abnormalities outside the area of surgical resection.
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Electrodes, Implanted↗
Clinical and MRI evidence that occipital lobe seizures can be the major manifestation of the reversible posterior leukoencephalopathy syndrome (RPLS)
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Brain↗
Increased neocortical spiking and surgical outcome after selective amygdalo-hippocampectomy.
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Amygdala↗
Correlation between mesial temporal and temporal neocortical interictal spiking in acute ECoG and chronic depth electrode recordings.
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Electrodes, Implanted↗
Epileptiform and non-epileptiform paroxysmal activity from isolated cortex after functional hemispherectomy.
The relationship of acute complete cortical isolation to paroxysmal cerebral activity was examined in 16 patients with electrocorticography (ECOG) before and after functional hemispherectomy (FH). Burst-suppression activity appeared over isolated cortex in all cases, the severity of which could be increased by systemic administration of propofol or methohexital. Interictal epileptiform activity (EA) recorded from frontal or parietal-occipital cortex before FH invariably persisted after FH (11 cases). No EA was recorded before or after FH in 3 cases while in 2 cases EA appeared following FH which had not been present before FH. The intensity of burst-suppression activity was not related to the presence or absence of post-excision EA. In total, 30 disconnected cortices were recorded from; relative abundance of EA was increased in 10, unchanged in 17, and decreased in 3 cases. Unrelated to the induction of burst-suppression activity, cortical isolation may decrease the threshold for expression of interictal EA.
Adolescent↗