Biomedical subjects
Publications and source records attributed to R A Voorsmit.
Most dento-alveolar traumas can be managed by the dentist-general practitioner. Still, there are some specific injuries which should be treated by dental specialists. Some specific guidelines are given for the combined surgical-orthodontic treatment of fracture of the coronal part of the root, intrusive luxation, abnormal position of the permanent tooth due to traumatic displacement of the deciduous tooth, ankylosis and tooth loss.
Skeletal Class III malocclusions are the result of deficient maxillary growth, excessive mandibular growth or a combination of both. Vertical as well as transverse dimensions can be disturbed too. Skeletal, dental and functional characteristics are described briefly. Treatment planning is outlined with special reference to the pattern of development during different growth stages and its consequences for therapeutical intervention. At last possibilities and limitations of surgical/orthodontic correction of the skeletal discrepancy and its dental compensations are discussed.
Rheumatoid arthritis patients have antibodies in their serum directed against the perinuclear factor, a protein component present in keratohyalin granules in the cytoplasm of human buccal mucosa cells. The anti-perinuclear factor (APF) can only be detected by an indirect immunofluorescence test performed on fresh buccal mucosa cells from 'selected donors'. To obtain a more reliable antigen source and to gain more insight into the origin and nature of the perinuclear factor we attempted to culture perinuclear factor-containing buccal mucosa cells. Here we describe the successful culturing of such cells, which, however, did not contain keratohyalin granules nor the perinuclear factor. By adding the phorbol ester 12-o-tetradecanoylphorbol-13-acetate (TPA) we were able to induce keratohyalin granules in both cultured primary buccal mucosa cells and a squamous carcinoma cell line of the cheek (SqCC/Y1). These induced keratohyalin granules do contain the protein profilaggrin, which in vivo, in fresh buccal mucosa cells, co-localizes with the perinuclear factor. However, we were not able to demonstrate the presence of the perinuclear factor, not even after induction of terminal differentiation of the cultured cells nor after Epstein-Barr virus infection. Our results suggest that the perinuclear factor, in contrast to profilaggrin, is not an integral component of buccal mucosa cells.
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The clinical and histological data concerning a case of sial -( ocyst )-adenoma papilliferum of the palate are presented. Ten cases of sialadenoma papilliferum have been reported to date. The lesion is characterized by several distinct clinical and histological features resembling in many aspects the syringocystadenoma papilliferum of the skin. Because of the invariable presence of more or less cystically dilated salivary gland ducts we propose to denote the lesion as sialocyst -adenoma papilliferum. Generally these neoplasms behave as benign tumours with an indolent and asymptomatic clinical course, although a single case of a malignant counterpart has been reported. An adequate local excision seems to be the treatment of choice. An accurate follow-up is required.
The clinical and histological data of 106 keratocysts from the files of the Department of Oral and Maxillofacial Surgery in Nijmegen and Arnhem, The Netherlands, formed the basis of this study. There was a wide age range with a male predominance and with the mandibular third molar area and ramus being the most common sites involved. Special attention has been drawn to the various ways in which recurrent keratocysts may develop. In the present study the recurrence rate of two groups of patients, treated according to two different concepts in the surgical management of keratocysts, are compared. As a result of a 21-year follow-up on 92 keratocysts a rational approach to the surgical treatment to eliminate a high recurrence rate is suggested.
The purpose of this retrospective study was to evaluate the clinical performance of and patients' satisfaction with maxillary overdentures retained by splinted and unsplinted implants. Patients who had been treated with maxillary implant-retained overdentures because of functional problems with conventional complete dentures were identified and invited to participate in the study. A total of 16 patients fulfilled the enrollment criteria and agreed to participate. Eleven patients were treated with bar-retained overdentures with 3 to 6 clips (mean follow-up 32 months), and 5 patients wore overdentures retained by 2 to 6 ball attachments (mean follow-up 54 months). All subjects were satisfied with their prostheses, and most subjects experienced improvement in their oral function after treatment with implant-retained overdentures. At the time of clinical examination, 92% (n = 77) of the 84 implants placed were functioning satisfactorily. The cumulative survival rate for the implants after 72 months was 90%. Loss of bone support correlated with peri-implant probing depth (r = 0.29; P < .02). No differences in mean bone loss between the subjects with ball-retained or bar-retained overdentures were found. The presence of plaque or peri-implant bleeding was not associated with the type of attachment.