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Biomedical subjects

R A Savage

Publications and source records attributed to R A Savage.

At least 19 recordsLinked to original sources
PubMed1991

Lumbar muscularity and its relationship with age, occupation and low back pain.

This paper considers an internal standard of lumbar muscularity. The cross-sectional areas (Acs) of the intervertebral disc and paraspinal muscles were measured in 147 working men from an axial magnetic resonance image passing through the L3-4 disc. Lumbar muscularity was expressed by two ratios; the ratio between the Acs of the right psoas and the Acs of the intervertebral disc (P:disc), and the ratio between the combined Acs values of the right erector spinae and quadratus lumborum and the Acs of the disc (ESQL:disc). When the subjects were divided into two age groups (76 aged 20-30 years and 71 aged 31-58 years) lumbar muscularity was found to be significantly greater (P less than 0.001) in the younger age group (P:disc = 0.8, SD 0.2; ESQL:disc = 2.0, SD 0.3) than in the older age group (P:disc = 0.7, SD 0.2; ESQL:disc = 1.8, SD 0.3). Lumbar muscularity was not significantly affected by occupation or by a history of low back pain.

Adult↗
PubMed1989

Analytic inaccuracy resulting from hematology specimen characteristics. Three cases of clinically misleading artifacts affecting white blood cell and platelet counts.

Sporadically, hematology analyzers generate grossly erroneous results for one or several parameters of the complete blood count (CBC) because of a characteristic or peculiarity of an individual patient specimen. This article presents three cases of relatively less well-known analytic errors of this sort, falsely elevating white blood cell count and platelet count and decreasing total white blood cell count, as determined on a Coulter Aperture Impedence Analyzer. The type of alteration in the CBC parameters and the instrument histogram abnormalities seen in each of these different types of analytic inaccuracy are discussed.

Adult↗
PubMed1987

Massive hemolysis in Clostridium perfringens infections.

Over a 14-month period at the Cleveland Clinic Foundation, 424 strains of Clostridium were isolated; of these, 52 strains were Clostridium perfringens isolated from 41 patients. Eight strains of C. perfringens were isolated from the blood of six patients; five of these patients had neoplastic disease and three developed massive intravascular hemolysis with rapidly developing shock and death. Clinical details are given on three patients with fatal Clostridium perfringens sepsis, and the nature of presentation and pathophysiologic mechanisms are discussed.

Blood Cell Count↗
PubMed1987

One ambiguity.

Explore the source record for details and available documents.

Anemia↗
PubMed1987

Marrow myxedema. Gelatinous transformation of marrow ground substance in a patient with severe hypothyroidism.

Replacement of marrow ground substance by hyaluronic acid-rich mucopolysaccharides (gelatinous transformation) has been previously reported to occur in severely malnourished patients. A patient with severe anemia and hypothyroidism without malnutrition was found to have gelatinous transformation of the marrow. This process is similar histologically to dermal myxedema, and the findings in this patient suggest questions for further study involving possible roles for thyroid-stimulating hormone in the development of marrow and visceral myxedema and the alterations in the normal partitioning process between serum and red blood cell low-density lipoproteins that produce acanthocytes in blood smears from patients with hypothyroidism.

Acanthocytes↗
PubMed1986

Lymphocyte percentage correlations for the Coulter S+IV.

Previously performed correlation studies involving the Coulter S+II TM demonstrated a statistically significant bias for lymphocyte enumeration as compared with the results of lymphocyte enumeration by an automated differential counting system manufactured by Geometric Data, the Hematrak TM. New data developed utilizing the Coulter S+IV TM indicates that the previous bias has now been eliminated.

Autoanalysis↗
PubMed1985

Evaluation of a computer assisted repeat prescribing programme in a general practice.

After introducing a computer assisted repeat prescribing programme into a south London practice improvements were made in several aspects of practice organisation. Time was saved by doctors and receptionists; prescriptions were produced more rapidly; information in the records about drugs that were available for repeat prescription was improved; and queries from chemists about prescriptions were reduced. The costs of the system in terms of computer operator time were estimated. Computerising prescribing data provides a source of data that may be used to enable doctors to audit their own prescribing.

Computers↗