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Biomedical subjects

R A Phillips

Publications and source records attributed to R A Phillips.

At least 253 records · Page 14Linked to original sources
PubMed1969

Report of the 1966-67 cholera vaccine field trial in rural East Pakistan. I. Study design and results of the first year of observation.

A controlled cholera vaccine field trial was carried out in rural East Pakistan during the 1966-67 cholera season. A commercial cholera vaccine of average potency was tested in 40 000 children aged 3 months to 14 years in 1- and 2-dose schedules. In the cholera season extending for 8 months following immunization, a single dose produced an over-all protection of 46%; 2 doses at an interval of 1 month provided 64% protection. The single dose was virtually ineffective in children under 5 years, but provided significant protection in older children. The enhanced effect of the 2-dose schedule was primarily due to the boosting of protection in children under the age of 5 years. The duration of significant protection, even with the 2-dose schedule, did not appear to extend beyond the first 3 months of the 8-month cholera season.

Adolescent↗
PubMed1969

Report of the 1966-67 cholera vaccine field trial in rural East Pakistan. 3. The lack of effect of prior vaccination or circulating vibriocidal antibody on the severity of clinical cholera.

In a controlled study, it has been shown that the prior administration of cholera vaccine had no beneficial effect on the clinical course of cholera as measured by either the condition of the patient on admission to hospital or the subsequent course of the disease. In fact, the disease was, if anything, more severe in those who had received cholera vaccine. Although the presence of a high vibriocidal titre is associated with protection from cholera, pre-existing antibody had no effect on the clinical course of the disease in those patients who developed cholera.

Adolescent↗
PubMed1968

Water and sodium absorption in the human intestine.

1. Studies are reported of total intestinal perfusion in man in which data relating to the absorptive capacity for water and sodium, flow rate transit time and intestinal volume have been obtained.2. A 'bolus' of radiosodium added to the steady-state perfusion has allowed measurement of bidirectional fluxes of sodium ion across the mucosa to be determined.3. The values obtained agree closely with those that can be predicted from small segmental studies reported in the literature.4. Increasing absorption capacity with increasing flow rate does not seem to reflect a true increase in absorption per unit of intestine but rather a progression to more nearly continuous flow conditions.

Humans↗