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Biomedical subjects

R A Ord

Publications and source records attributed to R A Ord.

82 records · Page 5Linked to original sources
PubMed1983

Cancrum oris: principles of management and reconstructive surgery.

A survey of 140 cases of cancrum oris in Nigerian Africans is presented. The salient clinical features, the problems of management and the modern approaches to the reconstruction of facial deformities seen in this disease are described. Mainly affected were children under the age of 10 years and the commonest involvement was the full thickness of the cheek. A high incidence of ankylosis was noted and the methods of anaesthesia and surgical correction of ankylosis are examined. The number of patients presenting for reconstruction of facial defects due to cancrum oris appears to be increasing. Preventive measures that may reduce the incidence of the disease are suggested.

Adolescent↗
PubMed1981

Investigation and management of orbital trauma.

Clinical examination and conventional radiography of the orbit following recent orbital trauma often gives an incomplete picture of the damage present. In many infra-orbital blowout injuries, damage to the medial orbital wall occurs with prolapse and sometimes incarceration of orbital contents into both the maxillary and ethmoidal air sinuses. Late enophthalmos is thought to be caused by both atrophy of orbital fat and its loss into the paranasal sinuses. Hypocycloidal tomography in an antero-posterior plane is helpful in the recognition of those defects, but it does not distinguish between the presence of blood clot and soft tissue. Computerised axial tomography (C.A.T.) and ultrasonography are currently available investigative techniques which do distinguish between the presence of air, blood clot, soft tissue and bone and, in addition, there is a significant reduction in radiation dosage when compared with tomography. A comparison of these techniques and the clinical findings is described. These investigations should indicate the necessity for surgical intervention and prevent some of the late complications, such as enophthalmos.

Humans↗
PubMedDate not supplied

Head and neck fibromyxoid sarcoma: clinicopathological correlation with emphasis on peculiar ultrastructural features related to collagen processing.

A fibromyxoid sarcoma of the jaw of a young patient is described. The tumor recurred and was locally aggressive but displayed mostly a low-grade morphology with only a few areas showing undifferentiated (high-grade) appearance. An isolated lung metastasis was identified 15 years after the original presentation. Ultrastructurally, the tumor cells showed features of partial fibroblastic differentiation, with abundant and often markedly dilated rough endoplastic reticulum cisternae, but also interrupted segments of basal lamina. The cytoplasm contained numerous large, spindle-shaped, membrane-bound inclusions of collagen that showed a complex triple periodicity. A distinct cell polarity was seen, with the nucleus at one end of the cell and the collagenous inclusions at the other. All of these features indicate a tumor with significant cytodifferentiation, correlating with the relatively protracted clinical course. The intercellular space contained mature collagen fibers and scattered aggregates of delicate, slender fibers embedded in moderately electron-dense granular matrix (fibrillogranular aggregates). The results suggest that based on its morphology and clinical presentation this tumor represents an unusual variant in the spectrum of fibromyxoid sarcomas.

Child, Preschool↗
PubMedDate not supplied

Proliferative verrucous leukoplakia: a case report.

Proliferative verrucous leukoplakia (PVL) is a particularly aggressive form of oral leukoplakia that is resistant to treatment and presents a high risk of recurrence and malignant transformation. This article describes the microscopic and clinical characteristics of one case of PVL, which initially presented as hyperkeratosis with mild dysplasia and posteriorly developed multifocal areas and verrucous carcinoma despite treatment.

Carcinoma, Verrucous↗