[Periodic disease--disease of the leukocytic granules].
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Biomedical subjects
Publications and source records attributed to R A Murav'ev.
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Functional properties of peroxidase-containing granules (peroxidasosomes) of eosinophiles are discussed. Findings are reported on the activities of peroxidase systems and of non-enzymic cationic proteins which occur in the eosinophilic peroxidasosomes in normal state and in various pathological states as well as their antimicrobial and antiparasitic activities.
Findings suggesting a vast variety of non-enzymic cationic proteins and peptides in human and animal leucocytes are reported. These cationic proteins and peptides demonstrate their antimicrobial and cytotoxic properties due to their detergent characteristics and their capacity to change the permeability of cellular wall and membrane by electrostatic interactions. Information on their homology with some serine proteases is presented.
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