Dopamine and prolactin in human pregnancy.
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Biomedical subjects
Publications and source records attributed to R A Munsick.
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This paper contains a table of predicted fetal or neonatal weight on the basis of the biparietal diameter. The tabulated values are derived under the assumption that the relationship between biparietal diameter and weight is nonlinear and that weight is best predicted by means of a third degree least square polynominal spline. We believe that our study overcomes the shortcomings inherent in a linear prediction formula, commonly employed in the literature.
Five successive groups of third-year medical students were identically tested on the subject "diagnosis of early pregnancy" at the end of their course in obstetrics and gynecology. The first group served as control, receiving no specific instruction on the subject. The next four groups did receive instruction on the subject and in the following ways: tape-slide program, lecture, instructional objectives alone, and instructional objectives plus the same tape-slide program. The average examination scores with S. D. were 40 plus or minus 11, 68 plus or minus 15, 48 plus or minus 17, 42 plus or minus 14, and 83 plus or minus 20 respectively. Analysis of these results reveals that the tape-slide program produced significantly better scores than an identical lecture or the objectives alone, but that accompanying the tape-slide program with the objectives maximized learning. Ramifications and causes of these findings are discussed in detail.
A potent topical anesthetic drug, 1% tetracaine, and a placebo were evaluated in a "double-blind" study to determine whether or not topical anesthesia could be achieved on the exocervix, endocervix, and endometrial cavity. No anesthetic effect of tetracaine was demonstrated.
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Identifying posterior pituitary hormones in body fluids or neurohypophysial extracts was heretofore partially achieved by using pharmacologic potency ratios or semispecific inactivation by thioglycolate or enzymes. Production of antisera against oxytocin and lysine-vasopressin has prompted us to test their specificity against lysine-vasopressin, arginine-vasopressin, arginine-vasotocin, and oxytocin. In ethanol anesthetized rats, antidiuretic and milk-ejection activities were assayed for each peptide-antiserum combination after 0, 30, 60, and 90 min of incubation. Results indicate that (a) oxytocin antiserum inactivates oxytocin, but not arginine-vasopressin, lysine-vasopressin, or arginine-vasotocin; vasopressin antiserum inactivates arginine-vasopressin and lysine-vasopressin, but neither oxytocin nor arginine-vasotocin; (b) an identifiable antigenic site exists for each hormone; (c) relatively specific identifications of natural neurohypophysial peptides are possible using antisera and bioassays; (d) this method is promising for identifying neurohypophysial peptides in body fluids and pituitary extracts; and (e) active and passive immunization against oxytocin and vasopressin may increase our understanding of their physiologic functions.
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