The association of readily-soluble bound phosphohistidine from mitochondria with succinate thiokinase.
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Animals↗
Biomedical subjects
R A Mitchell
Publications and source records attributed to R A Mitchell.
Community-based rehabilitation: a development programme in Negros Occidental.
This paper describes the establishment of a community-base rehabilitation (CBR) programme from its initiation to the current situation in the Philippine Republic. The impetus for the CBR project arose from an initiative of a non-government organization in the state of Negros Occidental. The administrative structure, manpower recruitment and training, and the close working relationship between government and non-government organizations are also described.
Adolescent↗
Altered immunologic function and nitrogen metabolism associated with depression of plasma growth hormone.
The specific role of endogenous growth hormone in regulating nitrogen metabolism during surgical stress and infection remains unclear. We have studied splanchnic amino acid uptake and plasma concentrations in patient groups exhibiting growth hormone hypersecretion or relative growth hormone depression in response to stress. Splanchnic amino acid uptake was similar in both groups although plasma levels were significantly higher in the presence of depressed growth hormone production suggesting increased net peripheral proteolysis. In association with this latter observation. T lymphocyte subset analysis revealed a greater incidence of depressed helper to suppressor cell ratios in the presence of depressed growth hormone suggesting a greater impairment of cellular immunity.
Aged↗
Endocrine mediators of metabolism associated with injury and sepsis.
We have studied the endocrine characteristics of 13 seriously ill patients with the use of a provocative intravenous glucose bolus. Notable in this stressed patient population was that no major interpatient differences in response to glucose were found for insulin, glucagon, cortisol, or epinephrine. However, following glucose challenge half of this group (7/13) exhibited a prominent "paradoxical" mean human growth hormone (hGH) elevation (26.4 +/- 9.3 microU/ml) whereas the others (6/13) exhibited only a minor increase (7.8 +/- 2.9 microU/ml). In addition, norepinephrine levels were significantly higher in the latter group suggesting that the adrenergic nervous system plays a major role in regulating hGH in stress.
Aged↗
Endovascular repair of thoracic aortic aneurysms: a paradigm shift in standard of care.
The standard open surgical treatment of thoracic aortic aneurysms is associated with significant morbidity and mortality. Endovascular repair is less invasive and potentially less morbid for patients with multiple risk factors. The authors report their results in 9 consecutive high-risk patients treated with endovascular grafts from January 1998 through June 2000. There were 7 men and 2 women patients with an average age of 75 years. Mean aneurysm diameter was 7.1 cm. All aneurysms were repaired with Gianturco Z-stent polytetrafluoroethylene prostheses. There were no perioperative deaths. Mean length of stay was 6.3 days. Technical success was achieved in all 9 patients. Two patients had neurologic complications following repair (1 patient with transient lower extremity numbness related to spinal arthritis and 1 patient with bowel and bladder incontinence). Both patients were independent with ambulation. Mean follow-up was 15.8 months. There was no evidence of endoleak or stent migration during the follow-up period. These findings support endovascular treatment of high-risk patients with thoracic aneurysm.
Aged↗
Emerging patterns of disability distribution in developing countries.
A study based on the WHO model of community-based rehabilitation in Guangzhou City, China, is described. Preliminary epidemiological data are reported, and compared with analogous data from Korea, Vietnam, Malaysia, Mexico, Indonesia, and Pakistan. Confidence levels for estimates of the prevalence of limb dysfunction, visual dysfunction, hearing and/or speech dysfunction, and mental retardation are also reported.
Adolescent↗
A cross-cultural assessment of perceived health problems in the elderly.
To study cross-cultural differences in perceived health problems in the elderly the Nottingham Health Profile (NHP) developed by Hunt et al. was administered to subjects from the People's Republic of China and Australia. The Australian stratum was further categorized according to cardiovascular status. Analyses of covariance (with age as the covariate) on each of the six subscales of the NHP yielded significant differences for 'Energy', 'Pain', 'Emotional reactions', 'Social isolation' and 'Physical mobility'. No differences were found for the 'Sleep' subscale. Through comparisons between the mean scores for the four strata and from normative data it is concluded that it is likely that the NHP is 'culture free' on the dimensions 'Energy', 'Pain', 'Emotional reactions', 'Social isolation' and 'Physical mobility'.
Aged↗
Community-based rehabilitation: does it change community attitudes towards people with disability?
To achieve the goal of 'Health for All by the Year 2000' the World Health Organization (WHO) adopted an approach to rehabilitation described as community-based rehabilitation (CBR). A major objective of CBR is to develop positive community attitudes towards people with disabilities. To determine whether this objective can be achieved, post hoc measurement of attitudes towards people with disabilities was carried out in a community in which CBR had been established and in a control community. It is shown that both groups exhibited neutral attitudes. The community exposed to CBR obtained a mean attitude score significantly (p < 0.001) closer to the positive end of the scale than did the control community. It is concluded that communities in which CBR is being carried out develop more favourable attitudes towards people with disabilities than do those in which no such programme has been implemented.
Adult↗
Effects of 100 per cent inspired oxygen on shunt calculation.
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Humans↗