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Biomedical subjects

R A Malt

Publications and source records attributed to R A Malt.

226 records · Page 13Linked to original sources
PubMedDate not supplied

MR imaging of hepatic focal nodular hyperplasia.

The magnetic resonance features of a case of focal nodular hyperplasia are described. They include mass effect with tumor nearly isointense with adjacent liver and a central stellate region corresponding pathologically to the collagenous scar.

Adenoma↗
PubMedDate not supplied

Reversal of biochemical and functional abnormalities in erythrocytes secondary to selenium deficiency.

A patient with multiple enterocutaneous fistulae on total parenteral nutrition for 14 months developed low erythrocyte selenium and low erythrocyte glutathione peroxidase. Erythrocyte hexose monophosphate shunt activity stimulated with an H2O2 generating system was approximately one-fourth that of control. Hexose monophosphate shunt activity stimulated with methylene blue showed little difference between patient and control. With selenium supplementation erythrocyte selenium, glutathione peroxidase, and hexose monophosphate shunt activity became normal. Thus, the biochemical and functional consequences of selenium deficiency can be corrected with selenium supplementation.

Adult↗
PubMedDate not supplied

Nutritional efficacy and hepatic changes during intragastric, intravenous, and prehepatic feeding in rats.

The nutritional efficacy and hepatic changes in rats given a total parenteral nutrition (TPN) solution consisting of 4.25% amino acids and 25% dextrose by intragastric, intravenous, or prehepatic routes were studied over a 4-day period. Rats fed Purina Chow or given intragastric TPN maintained body weight and showed no appreciable fatty change of liver. In contrast, weight loss, hepatomegaly, and a 37% increase in liver lipid content were observed in rats given intravenous TPN and a 60% increase after prehepatic TPN. Approximately half the rats given intravenous or prehepatic TPN developed fatty changes in the liver. Serum albumin concentration and hepatic protein content were not improved after prehepatic TPN. Serum SGOT and SGPT were elevated in rats given prehepatic TPN only. Prehepatic TPN may result in hepatic injury and offers no apparent benefit over conventional intravenous TPN in rats.

Animals↗
PubMedDate not supplied

Fat-based (Intralipid 20%) versus carbohydrate-based total parenteral nutrition: effects on hepatic structure and function in rats.

The role of fat-based total parenteral nutrition (TPN) in preventing or ameliorating hepatic dysfunction during TPN was investigated. Adult ACI-N rats were given fat-free carbohydrate-based TPN or isocaloric, isonitrogenous fat-based TPN (50% cal from 20% Intralipid, 50% cal from carbohydrate) for 7 days with Purina Chow-fed and fasting rats as controls. After fat-based TPN as compared with Chow or carbohydrate-based TPN, serum alkaline phosphatase activity and cholesterol levels doubled. Fatty infiltration and periportal inflammation in the liver were more marked. Both the TPN regimens were equally effective in maintaining body weight, positive nitrogen balance, muscle and hepatic protein content. Hepatic dysfunction in rats during TPN was not prevented by using a fat emulsion to provide 50% of the caloric requirement; the optimal proportion of fat as energy substrate in this system is less than 50%.

Alkaline Phosphatase↗
PubMedDate not supplied

Direct azygos vein and superior vena cava cannulation for parenteral nutrition.

As a result of superior vena cava thrombosis and ligation of the inferior vena cava, central venous access was limited in a patient with large, recurrent, intestinal fistulas. Transthoracic catheterization of the azygos vein provided a successful route for parenteral nutrition for 9 wk on one occasion, and transthoracic catheterization of the superior vena cava allowed parenteral nutrition for over 9 months on another.

Aged↗
PubMedDate not supplied

Total parenteral nutrition with and without fat as substrate for growth of rats and transplanted hepatocarcinoma.

Differential effects of total parenteral nutrition (TPN) on host nutrition and growth of cancer are unclear. Growth of adult ACI-N rats bearing transplanted Morris hepatocarcinoma no. 3924A given TPN with or without fat was studied in comparison with Purina Chow-fed, fasting, and semifasting (either amino acid or dextrose alone) rats over 5 days. The isocaloric, isonitrogenous TPN regimens with or without fat maintained body weight and nitrogen balance of cancer-bearing rats equally well. When compared with Chow-fed rats, the volume of the cancer, its weight, doubling time, protein content, and incorporation of thymidine into DNA were similar in rats given TPN either with or without fat. Although the volume of the cancer decreased in fasting and semifasting rats, the nutritional status of the host was also impaired. Administration of TPN to cancer-bearing rats was associated with an abnormal increase in serum lactic acid level, which was not ameliorated by the use of fat to reduce the carbohydrate load. Although TPN with and without fat maintains the nutritional status, hepatomegaly and hepatic steatosis limit the administration of carbohydrate and fat as energy substrates in this system.

Animals↗
PubMedDate not supplied

Macromolecular metabolism in compensatory renal hypertrophy.

1. The initial biochemical changes of compensatory hypertrophy occur well within 1 hour of unilateral nephrectomy and perhaps within the first few minutes.2. The initial increment in rRNA is from decreased metabolism rather than from increased synthesis.3. Changes in the processing of mRNA precursors are probably also important.4. Compensatory hypertrophy is regulated by a humoral stimulus or stimuli.5. The stimulus needs to be present virtually all of the time during the early phases of compensatory hypertrophy.6. The stimulus is related to loss of renal mass, not to loss of renal function.

Adaptation, Physiological↗