Efficacy of the BCG revaccination programme in Hong Kong.
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BCG Vaccine↗
Biomedical subjects
R A Green
Publications and source records attributed to R A Green.
A pilot study using magnetic resonance imaging to determine the pattern of muscle group recruitment by rowers with different levels of experience.
OBJECTIVE: To determine whether it was possible using magnetic resonance imaging (MRI) to define the pattern of muscle recruitment in a specific sport (rowing) and to see whether there were differences in this pattern between athletes of different experience. DESIGN AND METHOD: It has been shown that during vigorous exercise the water content of muscle increases transiently. This can be observed using MRI, where the prolonged T2 relaxation time of muscle can be demonstrated. In this study we have exploited the increase in signal seen in exercised muscle on short TI inversion recovery (STIR) sequences, to show how rowers of different experience use different muscle groups. RESULTS: We have shown that trained athletes recruit selected muscle groups to carry out a given task, which they carry out more efficiently than untrained or less experienced athletes. CONCLUSION: We have provided the basis of potential research to refine training methods, in order to develop specific muscle groups in athletes, in the hope of achieving a higher level of performance at an earlier stage in their training. We have also defined a technique that may be of clinical value in cases of muscle dysfunction.
Adult↗
Familial pulmonary hypoplasia: plain film appearances with histopathological correlation.
Familial pulmonary hypoplasia is a rare cause of bilateral pulmonary hypoplasia. We describe the plain film appearances and correlate these with the histopathological findings in an infant who survived 5 weeks. In this case, improved technology prolonged survival, allowing the radiological appearance of the primitive lung architecture to become more clearly defined.
Adult↗
Clotting times and antithrombin III activity in cats with naturally developing diseases: 85 cases (1984-1994).
OBJECTIVE: To determine the prevalence of abnormalities of in vitro prothrombin time (PT) and activated partial thromboplastin time (APTT), or antithrombin III (ATIII) activity or all 3 variables in cats; and the association of abnormalities of these variables with naturally developing diseases or disorders. DESIGN: Retrospective study. ANIMALS: 85 cats from which blood had been obtained for measurement of a coagulation profile (PT, APTT, and ATIII activity) and concentration of fibrin degradation products. PROCEDURE: Medical records from the Texas A&M College of Veterinary Medicine were reviewed to determine clinical diagnosis, results of CBC and coagulation profile, and clinical evidence of abnormal bleeding or thrombotic disease. RESULTS: 38 cats had one or more abnormality in the coagulation profile; most had multiple abnormalities. Twenty of these 38 cats had concurrent thrombocytopenia. Thrombocytopenia was identified in 9 of 47 cats in which results of the coagulation profile were normal. Most cats did not have clinical evidence of a coagulation disorder, and testing had been requested as part of a diagnostic work-up or before surgery. Diseases commonly associated with laboratory evidence of a coagulation disorder, either singly or in combination, included hepatic disease, neoplasia, and systemic infections. CLINICAL IMPLICATIONS: On the basis of laboratory evidence, hemostatic disorders develop more commonly in cats than clinical signs would suggest. Coagulation profiles may be warranted in high-risk cats to alert clinicians to potential problems.
Animals↗
Angioplasty balloon rupture: a way round the embolised fragment.
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Aged↗
Elimination of dog ear during reduction mammaplasty.
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Cicatrix↗
Antipyrine and caffeine dispositions in clinically normal dogs and dogs with progressive liver disease.
Dispositions of caffeine and antipyrine were compared as indicators of decreasing hepatic function in dogs with experimentally induced progressive liver disease. Dimethylnitrosamine, a hepatospecific toxin, was administered orally to 16 dogs; 6 dogs served as controls (group 1). Three classes of liver disease were defined by histologic features: mild (group 2; n = 5), moderate (group 3; n = 6), and severe (group 4; n = 5). Disposition of antipyrine, and 24 hours later, caffeine was studied 3 weeks after the last dose of toxin in each dog. For both drugs, rapid IV administration of 20 mg/kg of body weight was administered and serum samples were obtained at intervals for determination of at least 5 terminal-phase drug half-lives. For both drugs, clearance and mean residence time differed among groups (P < or = 0.01). Clearance of antipyrine and caffeine was decreased in groups 3 and 4, compared with groups 1 and 2. Antipyrine and caffeine mean residence times were longer in group-3 dogs, compared with dogs of groups 1 and 2. Correction of caffeine and antipyrine clearances for hepatic weight increased discrimination between groups 3 and 4. The clearance and mean residence time ratios of antipyrine to caffeine were calculated for each group and, when compared with values for group-1 dogs, were used to test for differences between the 2 drugs in response to disease. Ratios did not differ among groups. These results indicate that the disposition of antipyrine and caffeine may change similarly with progression of dimethylnitrosamine-induced liver disease.
Analysis of Variance↗
Effects of single-dose L-asparaginase on coagulation values in healthy dogs and dogs with lymphoma.
Ten healthy dogs and 10 dogs with multicentric lymphoma were given a single dose of L-asparaginase at a rate of 10,000 IU/m2 of body surface. Assessment of concentrations of contributors to the coagulation process and of the ability to coagulate including antithrombin III, one-stage prothrombin time, prothrombin-proconvertin time, activated partial thromboplastin time, plasminogen, fibrinogen, and platelet number were performed prior to drug administration (day 0). These tests were repeated 24 hours (day 1), 48 hours (day 2), and 7 days after treatment with L-asparaginase. Antithrombin-III concentrations were significantly lower in the dogs with lymphoma than in healthy dogs on days 0, 1, 2, and 7; however, with the exception of day 1, mean values remained within normal limits. There was also a difference between the 2 groups in prothrombin/proconvertin values on day 7 and in platelet number on day 2, with the lymphoma group having significantly shorter prothrombin/proconvertin time than healthy dogs, and the difference in platelet numbers being associated with increased counts in the healthy dogs. Data obtained from the healthy dogs and dogs with lymphoma for each coagulation test were pooled for each treatment day (0, 1, 2, and 7), and day-0 values for each coagulation test were compared with data obtained on days 1, 2, and 7. Antithrombin-III concentration on day 7 was significantly lower than on day 0, prothrombin/proconvertin time on day 1 was significantly longer than on day 0, and fibrinogen concentrations on days 1 and 2 were significantly lower than on day 0.(ABSTRACT TRUNCATED AT 250 WORDS)
Animals↗
Indocyanine green disposition in healthy dogs and dogs with mild, moderate, or severe dimethylnitrosamine-induced hepatic disease.
Disposition kinetics of indocyanine green (ICG) were used to evaluate hepatic function in healthy Beagles (group 1; n = 6) and Beagles with progressive hepatic disease induced by oral administration of dimethylnitrosamine, a hepatospecific toxin. Three classes of hepatic disease were defined by histologic features: mild (group 2; n = 5), moderate (group 3; n = 6), and severe (group 4; n = 5). Disposition of ICG was studied 3 weeks following the last dose of toxin. A rapid IV injection of 0.5 mg of ICG/kg was administered and serum samples were obtained at certain intervals during 60-minute periods. Serum ICG was analyzed by use of visible spectrophotometry. Disposition kinetics were determined from serum ICG concentrations vs 15- and 60-minute time curves and compared between one another and among groups. Data based on 60-minute time curves were not significantly different from those based on 15-minute curves. Area under the curve for ICG was greatest in group 3. Clearance of ICG was decreased and mean resident time was increased in groups 3 and 4, compared with those in groups 1 and 2. When disposition data (60 minutes) were normalized for differences in hepatic weight among dogs, group-3 mean resident time was significantly greater than that of group 4. This study supports the diagnostic benefits of using ICG disposition kinetics as a method of evaluating hepatic function in dogs with progressive liver disease.
Animals↗
Dimethylnitrosamine-induced hepatotoxicosis in dogs as a model of progressive canine hepatic disease.
A model of toxin-induced progressive hepatitis is described in Beagles. The toxin, dimethylnitrosamine, was administered orally to 18 Beagles; 6 dogs comprised a control group. Clinical signs and laboratory test results were monitored as disease progressed and were used to determine the end point of disease. Following euthanasia, histologic lesions were scored and used to derive a total severity score for each dog. Severity scores were then used to allot the 18 dogs to 3 groups of hepatic disease, defined as mild, moderate, or severe. Changes in clinical laboratory test results, including tests of hepatic function, and clinical signs indicative of liver disease were described chronologically for all dogs. Group means of clinical laboratory test results and quantifiable clinical signs (eg, weight loss and ascitic fluid accumulation) were compared. This model offers several advantages, compared with other experimental models of canine hepatic disease. These include hepatospecificity, similarity to natural disease (eg, the development of multiple extrahepatic portosystemic shunts), and the ability to titrate the disease to a desired end point. The major disadvantages of this model were the toxic nature of the drug to human beings and the variation in individual animal response to the toxin, which precludes preassignment of animals into groups.
Animals↗
Microcomputer video image processing technology in working posture analysis: application to seated postures of keyboard operators.
A new two-dimensional video-based technique for the recording and analysis of working posture has been developed and applied to seated work. After initial set-up of the portable equipment in the workplace, and attachment of small adhesive retroreflective joint markers on the subject, an operator is not required for the remainder of the recording session. Analysis of the video recording is conducted in the laboratory using custom-written software and a commercially available image-processing package running on an IBM AT-compatible computer. After interactive set-up of a reference frame, the system is able to analyse the full video tape automatically, extracting video frames for analysis at approximately 30-s intervals. Poor image quality may occasionally necessitate interactive analysis. The system is capable of determining postural angles to an accuracy of 1-2 degrees , and thus represents a substantial improvement on other postural analysis systems which are able to be used readily in the workplace.
Journal Article↗
Factors related to working posture and its assessment among keyboard operators.
Video analysis of 15 keyboard operators was conducted over two four-hour periods to determine the effects of symptoms of over-use injury, the adjustability of the workstation, the type of keyboard, time of day and sex on working posture. The only factor which significantly affected posture was the type of keyboard, with operators at typewriters adopting a more extended shoulder position, reduced elbow flexion and increased wrist flexion, than those working at a VDU terminal. Analysis of the components of variance associated with repeated observations revealed that to minimise the variance associated with recording the posture of these subjects, and therefore obtain a representative mean posture, required at least nine observations for wrist angle, four for elbow angle, six for shoulder angle and three for trunk incline. The mean posture adopted by this group of operators was similar to the 'right angles' posture, with the trunk reclined 4 degrees , shoulder extended 1 degrees , elbow 92 degrees and wrist extended 7 degrees .
Journal Article↗
The correlation of subcarinal density visualized on plain chest roentgenograms with computed tomographic scans.
A prospective evaluation of 212 paired chest roentgenograms and computed tomographic (CT) scans was performed to determine the predictive value of detecting subcarinal adenopathy by finding increased subcarinal density on routine roentgenograms. Based on CT criteria for subcarinal lymphadenopathy, 37 true-positive and 124 true-negative cases of subcarinal adenopathy were found in 161 patients. Evaluation of density in the subcarinal area on the routine posteroanterior (PA) chest roentgenograms in these patients demonstrated a sensitivity of 72 percent and specificity of 96 percent for the detection of adenopathy when compared with established CT criteria. False-positive and false-negative appraisals of central mediastinal density on routine roentgenograms appear to be due to the super-imposition of other masses, bullae, or lack of appropriate roentgenographic contrast. The accuracy of predicting the presence or absence of subcarinal adenopathy from routine chest roentgenograms suggests that this observation is clinically useful and should be routinely evaluated.
False Negative Reactions↗
Effect of overuse injury and the importance of training on the use of adjustable workstations by keyboard operators.
The introduction of adjustable workstations for keyboard operators has been widely recommended to eradicate constrained working postures leading to the development of musculoskeletal disorders. A questionnaire evaluating the use of adjustable workstations was analyzed for 514 keyboard operators. Anthropometric dimensions and workstation settings were measured for 15 operators. There was no difference between sufferers and nonsufferers of overuse injury on the basis of adjustability of their equipment. However, sufferers were less satisfied with their equipment and there was evidence that inappropriate postures were being adopted. The availability of adjustable equipment per se does not necessarily solve the problem. The design of the equipment must be based on suitable anthropometric data and operators must be trained in the correct use of the equipment. The results of this study indicate a perceived need for training and/or information on workstation adjustment among operators, with a preference for information that is supplied verbally, rather than in literature form.
Anthropometry↗
Anthropometric dimensions and overuse injury among Australian keyboard operators.
This study was instigated to examine the relationship between overuse injury and anthropometric dimensions of Australian keyboard operators to investigate the possibility that a poor anthropometric fit of the workstation may result in greater incidence of such disorders. There were no differences between the anthropometric dimensions of sufferers and nonsufferers of overuse injury among the male keyboard operators. Among men in this study, stature and several other anthropometric dimensions as a proportion of stature were similar to those of North American and European populations for which equipment used in Australia is designed. In contrast, among women, significant differences were evident between sufferers and nonsufferers. The sufferers had greater hip widths and seat breadths, and a greater proportion were overweight (body mass greater than 26). There was also a tendency for shorter limb segment lengths among the sufferers. The women as a group, and the sufferers in particular, had several anthropometric dimensions that, as a proportion of stature, were outside the range of reference populations for design of Australian office workstations. The subject numbers in the present study are relatively small; however, they suggest that a proportion of the female population may not be accommodated by equipment currently in use. The increased proportion of sufferers who are overweight may suggest a relationship between overuse injury and lack of exercise, since the latter is well known to cause increased weight. A longitudinal study is needed to confirm this observation.
Adult↗
3H-amino acid incorporation into proteins during chronic aflatoxin induced coagulation defects in rabbits.
Eighteen New Zealand White rabbits were divided equally into three groups and administered either 0.2 ml dimethyl sulfoxide (DMSO)/day, 0.06 mg/kg/day Aflatoxin B1 (AFB1) in DMSO, or 0.09 mg/kg/day AFB1 in DMSO. Incorporation of 3H-amino acids into total serum protein, fibrinogen and platelet proteins was determined during the intoxication and developing coagulation defect. Ten of 18 rabbits administered AFB1 in DMSO died or developed prolonged coagulation times. There was no significant difference in specific incorporation of 3H-amino acids into total serum protein, fibrinogen or platelet proteins between groups, nor was there a difference in incorporation between rabbits with normal coagulation times and those with prolonged coagulation times. Correlation between plasma fibrinogen concentration and specific incorporation of 3H-amino acid into fibrinogen was not significant. In vivo inhibition of 3H-amino acid incorporation into plasma proteins or platelets could not be demonstrated.
Aflatoxin B1↗
Pathophysiology of antithrombin III deficiency.
This article focuses on the pathophysiology of thrombosis in patients with acquired antithrombin III deficiency. Antithrombin III is an important natural inhibitor of the hemostatic mechanism, and a hypercoagulable state is often induced in diseases causing antithrombin III deficiency. Laboratory determination of antithrombin III activity is particularly useful in the clinical evaluation and therapeutic management of patients with disseminated intravascular coagulation, nephrotic syndrome, and severe hepatopathy.
Animals↗
Mondor's disease in plastic surgery patients.
Thrombophlebitis of the chest wall is a benign, self-limiting condition. When it is recognized, the patient can be confidently reassured that spontaneous resolution is expected. The characteristic cutaneous cords are palpable five to seven weeks postoperatively, and they generally resolve within several months without specific therapy. Mondor's disease appears to be related to injury of the subcutaneous chest veins at the initial surgery rather than at reoperation. There is no apparent relationship between Mondor's disease and silicon implants nor between Mondor's disease and capsule contracture. Mondor's disease may be more common then generally believed.
Adult↗