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Biomedical subjects

R A Good

Publications and source records attributed to R A Good.

At least 1,153 records · Page 64Linked to original sources
PubMed1968

Lymphoepithelial tissues of the intestine and differentiation of antibody production.

The antibody response of young rabbits to the injection of killed Brucella abortus was abolished by prior extirpation of intestinal lymphoepithelial tissues combined with lethal xirradiation and reconstitution with rabbit fetal liver cells. Extirpative surgery alone, like lethal x-irradiation and reconstitution without surgery, did not abolish this response. Intestinal lymphoepithelial tissues of rabbits apparently play a central lymphoid function and are responsible for the differentiation of the lymphoid cell line which produces specific antibody and immunoglobulins.

Animals↗
PubMed1968

Abnormalities of in vitro lymphocyte responses during rubella virus infections.

In vitro rubella virus infections of lymphocytes from normal adult humans impaired their responsiveness to phytohemagglutinin (PHA) stimulations; a situation which seemed analogous to the PHA unresponsiveness of peripheral lymphocytes from babies with the congenital rubella syndrome. Such in vitro viral infection of normal cells also decreased the synthesis of normal nucleic acids and structural proteins, and abrogated the enhanced DNA synthesis induced by pokeweed and specific antigen stimulations. Furthermore, it was shown that live rubella virus, but not ultraviolet-irradiated virus, was necessary for the impaired mitogenic responses of normal leukocytes. These observations are interpreted to favor the view that the virus achieves its inhibitory effect on the action of mitogens by interference either directly or indirectly at an intracellular site. Such an action could reduce the functional potential of lymphocytes and impair their effectiveness as immunologically competent cells or as effectors in immunologic reactions.

Antibody Formation↗