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Biomedical subjects

R A Frayha

Publications and source records attributed to R A Frayha.

At least 37 records · Page 2Linked to original sources
PubMed1978

Erythema nodosum-arthopathy complex as an initial presentation of Behçet's disease. Report of five cases.

In five males an erythema nodosum-arthropathy complex preceded the classical oro-genito-ocular triad of Behçet's disease by an average of 27 months. This symptom complex involving the legs initially suggested "idiopathic" erythema nodosum syndrome or acute sarcoidosis. As the diagnosis of Behçet's disease is clinical, these protean manifestations shoud be recognized as a possible "forme fruste" of the disease.

Adult↗
PubMed1977

Familial CRST syndrome with sicca complex.

Two patients, a mother and daughter, each with the CRST syndrome, developed Sjögren's syndrome. Both patients had mitochondrial antibodies, smooth muscle antibodies, and a raised serum IgM without clinical evidence of liver disease. This family constitutes the first record of the familial coexistence of the CRST syndrome with Sjögren's syndrome, and the second evidence of vertical inheritance of scleroderma. It is suggested that patients with the CRST syndrome be studied for Sjögren's syndrome and for autoimmune liver disease.

Adult↗
PubMed1976

Multiple vacuum discs, and early sign of ochronosis. Radiologic findings in two brothers.

Two brothers with ochronosis are reported and the radiological features of ochronotic vertebral disease are reviewed. A striking feature was the presence of multiple vacuum discs. This "vacuum phenomenon" constitutes one of the earliest radiologic changes in the spine and presumably represents areas of severe degeneration within the intervertebral discs. Other features included a dark pigmentation of the urine after standing or following the addition of sodium hydroxide, and calcification within the cartilages of the ears and intervertebral discs. There was no abnormality of the peripheral joints and pigmentary deposits in the ears, sclerae, or skin were not observed.

Adult↗