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Biomedical subjects

R A Eiferman

Publications and source records attributed to R A Eiferman.

At least 73 records · Page 4Linked to original sources
PubMed1981

Metastatic renal cell carcinoma to the eye and adnexae: a report of three cases and review of the literature.

Three cases of metastatic renal cell carcinoma to the ocular structures are presented. Each of these tumors clinically simulated a more common ocular entity, thus causing diagnostic difficulty. The first patient had a metastatic tumor to the eyelid that clinically simulated a large chalazion. The second patient had a choroidal tumor with clinical features and ancillary studies strongly suggestive of a primary choroidal melanoma. The third patient presented with unilateral proptosis secondary to an orbital mass that was clinically believed to be a cavernous hemangioma of the orbit. In each case, there was a long interval between the ocular metastasis, which represented the first sign of metastatic disease.

Adenocarcinoma↗
PubMed1981

Squamous epithelial implantation cyst of the iris.

A case of an iris implantation cyst was managed by penetrating keratoplasty and iridocyclectomy. The histology and electron microscopy of the cysts are described as well as the clinical histories and photographs of six additional cases. The potential complications of iris implantation cysts are iritis, cataracts, glaucoma, and decreased vision. Since ruptured cysts can cause an epithelial downgrowth, in toto removal was indicated in this case.

Adult↗
PubMed1981

Cutaneous sarcoidal granulomas and the development of systemic sarcoidosis.

Studies of patients with systemic sarcoidosis have indicated that those patients with cutaneous lesions have a poorer prognosis with a greater incidence of symptomatic pulmonary and ocular sarcoidosis. We examined 18 patients who had biopsy-proved cutaneous sarcoidosis for evidence of systemic involvement. Of the 13 patients who had no history of previously documented sarcoidosis, six had no evidence of systemic disease on history and physical examination, chest roentgenogram, pulmonary function testing, ocular examination, skin testing, and baseline laboratory testing. The seven remaining patients had evidence of sarcoidosis in another organ system, but six of the seven were essentially asymptomatic and required no therapy. The poorer prognosis associated with cutaneous sarcoidal granulomas drawn from populations with proved systemic sarcoidosis does not seem to apply to generally healthy outpatients with skin lesions as the initial manifestation of their disease.

Adult↗
PubMed1981

Ocular anomalies simulating double optic discs.

Three lesions simulating duplication of the optic disc are described. In case 1 the lesion was thought to be an ectatic peripapillary coloboma. Computer-assisted tomography demonstrated a single optic nerve in each orbit. In case 2 two optic disc with separate vascular systems were observed in photographs; blood vessels arising from the upper disc appeared to supply the superior portion of the retina, including the fovea. In case 3 a colobomatous defect with vascular anastomosis to the optic disc was observed in photographs. The resemblance of duplication of the optic disc to congenital disc anomalies, ectatic peripapillary colobomas and other simulating lesions is discussed. True duplication of the optic disc with associated duplication of the optic nerve is rare.

Coloboma↗
PubMed1980

Unusual superficial stromal corneal deposits in IgG kappa monoclonal gammopathy.

Unusual corneal stromal deposits at the level of Browman's membrane and superficial stroma were associated with severe photophobia and tearing as the initial signs of an IgG kappa monoclonal gammopathy. A corneal biopsy specimen showed superficial stroma areas that stained red with Masson trichrome stain. These deposits were positive for IgG and kappa chains. Histopathologic examination revealed focal disruption in Bowman's membrane with extension into the epithelium. Electron microscopy of the deposits disclosed parallel linear profiles compatible with immunoglobulin.

Adult↗
PubMed1979

Herpetic whitlow and heratitis.

Two patients had herpes simplex infection of the fingertips (herpetic whitlow) associated with herpetic keratitis. Both patients were health-care professionals who probably acquired their disease from patients. Herpetic whitlow can be distinguished from a paronychia by the lack of a tense pulp space, formation of vesicles, and serous (rather than purulent) drainage. The fingertip inflammation resolves spontaneously, leaving normal healthy skin, in about two weeks.

Adult↗
PubMed1979

Cryotherapy of Pseudomonas keratitis and scleritis.

Three cases of perforated Pseudomonas corneal ulcers with scleral extension were treated with keratoplasty and cryotherapy to the remaining cornea and sclera. All three cases showed dramatic improvement. Cryotherapy of Pseudomonas keratitis in guinea pigs has been shown to be effective. Pseudomonas organisms seem to be susceptible to cryotherapy in vivo; there is no effect in vitro. Cryotherapy may prove to be a new tool in the treatment of Pseudomonas keratitis.

Adult↗
PubMed1979

Peripheral rheumatoid ulceration and evidence for conjunctival collagenase production.

Two patients with rheumatoid arthritis and peripheral corneal ulcerations were successfully treated by conjunctival resection. The tissues removed were assayed by a variation of the radial diffusion method for tissue collagenases. We used an agarose matrix containing lathyritic rat skin collagen. Wells 3 mm deep were punched in the agarose-collagen and surgical specimens were placed in the wells. Spaces remaining in the wells were filled with balanced salt solution. The assay dishes were incubated for four days at 32 degrees C near 100% humidity. Under these conditions release of collagenase was detected by the clearing of diffuse zones in the gel surrounding the well. Conjunctiva proximal to the ulcer produced definite zones of lysis, whereas control specimens taken remote to the ulceration produced no lysis. This direct evidence for collagenase involvement offers an exploration for the beneficial effects of conjunctival resection.

Aged↗
PubMed1979

Immunological aspects of superior limbic keratoconjunctivitis.

Three patients with superior limbic keratoconjunctivitis (SLK) were treated by conjunctival resection. The results of immunological studies and histological examination of the excised tissue were unremarkable; none of seven criteria of antibody dependence were met. We found no specific immune defects in three patients with superior limbic keratoconjunctivitis.

Adult↗
PubMed1978

Inhibition of adenovirus replication in vitro by trifluridine.

At present, there is no effective chemotherapeutic agent available for the treatment of adenoviral keratoconjunctivitis. Recent evidence suggests that trifluridine (3FT) may effectively inhibit the replication of some adenovirus serotypes known to cause keratoconjunctivitis. The ability of 3FT to inhibit two reference strains of adenoviruses, type 8 and type 19, was examined using cell cultures. Two second-passage isolates of adenoviruses, identified as serotype 13, were also tested. Compared with untreated, virusinfected cell cultures, drug-treated cell cultures developed a lesser degree of cytopathic effect following infection with all three serotypes. Virus production was reduced in the drug-treated cell cultures: approximately tenfold for type 8, more than 1,000-fold for type 19, and 5,000-fold for the type 13 isolates.

Adenoviridae↗
PubMed1978

Limbal immunopathology of Mooren's ulcer.

A patient with a progressive Mooren's ulcer of the cornea was successfully treated utilizing a peritomy with limbal conjunctival excision and cryotherapy. The limbal conjunctiva contained a band of IgG beneath the epithelium as well as complement and fibrin in the wall of small blood vessels. This implies Mooren's ulcer is an immune mediated process.

Adult↗
PubMed1977

Double controlled comparison of IDU and trifluorothymidine in thirty-three patients with superficial herpetic keratitis.

Thirty-three patients were followed in a double controlled study to test the efficacy of IDU and TFT on superficial epithelial herpes simplex virus infection. Sixteen received TFT and 17, IDU. There were four failures in patients on IDU therapy and no failures in the 16 patients using TFT. These results indicate a trend for greater efficacy of TFT than IDU. In those patients who healed with IDU and with TFT, there was no difference in the number of days to heal in each group.

Acute Disease↗
PubMed1977

IgE in limbal conjunctiva in Mooren's ulcer.

A patient with a severe, progressive Mooren's ulcer was unsuccessfully treated by limbal conjunctival resection and cryotherapy. The excised conjunctiva demonstrated a band of IgE along the basement membrane.

Conjunctiva↗
PubMedDate not supplied

Meningeal carcinomatosis secondary to malignant lymphoma (Burkitt's pattern).

The clinical and histopathological features of a case of carcinomatous optic neuropathy secondary to a malignant lymphoma histologically resembling "Burkitt's tumor" occurring in an 11-year-old American male was described. Histological examination of the optic nerve showed meningeal involvement by tumor cells with extension into the septal spaces of the optic nerve.

Abdominal Neoplasms↗