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Biomedical subjects

R A Dale

Publications and source records attributed to R A Dale.

27 records · Page 2Linked to original sources
PubMed1969

Amino ketone synthesis in avian erythrocytes.

1. The relative rates of synthesis of aminolaevulate and aminoacetone by particles prepared from avian erythrocytes were measured under various conditions. 2. The production of both amino ketones by fresh particles was about three times greater in anaemia caused by phenylhydrazine and acetylphenylhydrazine than in anaemia caused by removal of 20-30ml. of blood. 3. The synthesis of aminolaevulate by freeze-dried particles decreased more than that of aminoacetone in the absence of added pyridoxal phosphate, in the presence of cyanide and of tris buffer, and after preincubation of the erythrocyte particles. Other differences in the rates of synthesis of the two amino ketones were observed after (a) incubation of particles at different temperatures and (b) storage of homogenized freeze-dried particles at different pH values. 4. It is suggested that these differences in the production of the two amino ketones are due to the presence of two amino ketone synthetases or to two or more isoenzymes of aminolaevulate synthetase. 5. The metabolic significance of aminoacetone in erythrocytes is discussed.

Amino Acids↗
PubMed1965

Correlations between components of the glycolytic pathway.

1. The contents of dihydroxyacetone phosphate, fructose diphosphate, pyruvate and lactate and the activities of aldolase and lactate dehydrogenase in the liver, kidney, testis, skeletal muscle, blood cells, sarcoma and hepatoma of rats were measured. 2. Correlations were established between components of the glycolytic pathway as follows: activities of aldolase and lactate dehydrogenase; contents of fructose diphosphate and pyruvate; activity of aldolase and content of fructose diphosphate; activity of lactate dehydrogenase and contents of fructose diphosphate and of pyruvate.

Animals↗
PubMedDate not supplied

Necrotizing fasciitis of the head and neck: review of the literature and report of a case.

Necrotizing fasciitis is a rapidly spreading, life-threatening, bacterial disease. Mortality rates have been estimated to vary between 8.7% and 74%. Mortality depends on many factors, one of which is early recognition. Necrotizing fasciitis of dental origin has a low prevalence and as such presents diagnostic challenges for the dentist. The literature is reviewed, and a case history is presented.

Diagnosis, Differential↗