Search PubMed⌕ Search

Biomedical subjects

R A Carter

Publications and source records attributed to R A Carter.

29 records · Page 2Linked to original sources
PubMed1969

Iron metabolism in the anaemia of chronic renal failure. Effects of dialysis and of parenteral iron.

Serial studies of iron transport in patients on maintenance dialysis showed normal or raised values in almost all subjects and a transient increase soon after the start of dialysis in three. These patients, who were seldom or never transfused, had low serum iron levels and normal iron-binding capacity with low saturation. Iron transport was substantially increased by parenteral iron-dextran treatment. Tracer studies showed good iron utilization, with transport to the marrow rather than to the liver. In these circumstances iron therapy is safe and beneficial, and a useful rise in red cell mass was shown to result from it. The packed cell volume was found to be a valid index of red cell mass in these patients. Red cell loss in the dialysers was insufficient to account for the observed reduction in red cell survival.

Adult↗
PubMed1966

Assessment of the combined usefulness in thyroid function testing of the triiodothyronine resin-sponge and 24-hour iodine uptakes.

Iodine and resin sponge uptake tests have been performed upon 124 consecutive patients referred for thyroid studies. Neither test alone could correctly identify all cases of thyrotoxicosis or myxoedema, but when considered in combination diagnostic efficiency was much improved. This combination of tests is shown to be especially useful in the investigation of patients with changes in body iodine pools or thyroxine-binding globulin levels. Reasons are given for regarding this pair of tests as being more generally useful than any of the other possible combinations at present available. The resin sponge test kit was found to be satisfactory both technically and in respect of cost.

Blood↗
PubMedDate not supplied

Sexual orientation and health: comparisons in the women's health initiative sample.

CONTEXT: Little is known about older lesbian and bisexual women. Existing research rarely compares characteristics of these women with comparable heterosexual women. OBJECTIVE: To compare heterosexual and nonheterosexual women 50 to 79 years on specific demographic characteristics, psychosocial risk factors, screening practices, and other health-related behaviors associated with increased risk for developing particular diseases or disease outcomes. DESIGN: Analysis of data from 93,311 participants in the Women's Health Initiative (WHI) study of health in postmenopausal women, comparing characteristics of 5 groups: heterosexuals, bisexuals, lifetime lesbians, adult lesbians, and those who never had sex as an adult. SETTING: Subjects were recruited at 40 WHI study centers nationwide representing a range of geographic and ethnic diversity. PARTICIPANTS: Postmenopausal women aged 50 to 79 years who met WHI eligibility criteria, signed an informed consent to participate in the WHI clinical trial(s) or observational study, and responded to the baseline questions on sexual orientation. MAIN OUTCOME MEASURES: Demographic characteristics, psychosocial risk factors, recency of screening tests, and other health-related behaviors as assessed on the WHI baseline questionnaire. RESULTS: Although of higher socioeconomic status than the heterosexuals, the lesbian and bisexual women more often used alcohol and cigarettes, exhibited other risk factors for reproductive cancers and cardiovascular disease, and scored lower on measures of mental health and social support. Notable is the 35% of lesbians and 81% of bisexual women who have been pregnant. Women reporting that they never had sex as an adult had lower rates of Papanicolaou screening and hormone replacement therapy use than other groups. CONCLUSIONS: This sample of older lesbian and bisexual women from WHI shows many of the same health behaviors, demographic, and psychosocial risk factors reported in the literature for their younger counterparts, despite their higher socioeconomic status and access to health care. The lower rates of recommended screening services and higher prevalence of obesity, smoking, alcohol use, and lower intake of fruit and vegetables among these women compared with heterosexual women indicate unmet needs that require effective interactions between care providers and nonheterosexual women.

Adaptation, Psychological↗
PubMedDate not supplied

Intramuscular tobramycin pharmacokinetics in geriatric patients.

Twelve elderly institutionalized patients (mean age of 81 years) received intramuscular injections of tobramycin for infections at regular dosage intervals. The subjects had stable renal function but had limited mobility. Periodic blood specimens were collected for eight hours and analyzed for tobramycin by an immunofluorescence technique. The procedure was repeated in each patient one day later to detect day-to-day variability in the absorption kinetics. The absorption of tobramycin occurred primarily within two hours, although peak concentrations in some patients were indicative of a sustained plateau and exhibited intrapatient variability from one dose to the next. The time to peak and slowly declining concentrations suggest that the absorption process is extended in this population as compared to younger adults. Our data suggest that peak tobramycin concentrations following intramuscular injections to geriatric patients may be slightly delayed, though the extent of absorption appears to be consistent.

Aged↗
PubMedDate not supplied

Assessing the fertility potential of equine semen samples using the reducible dyes methylene green and resazurin.

The objective of this study was to determine if spermatozoal reduction of the dyes methylene green to colorless and resazurin to pink or colorless was associated with the fertility potential of an equine semen sample. Fifty samples from 38 stallions were evaluated for the number of spermatozoa per milliliter and number of motile sperm per milliliter. Methylene green (20 micrograms/mL of semen) or resazurin (85 micrograms/mL of semen) was added to 3-mL aliquots of semen. Semen samples were identified as having low fertility potential (< 200 x 10(6) total cells/mL and < 140 x 10(6) motile cells/mL) or high fertility potential (> or = 200 x 10(6) total cells/mL and > or = 140 x 10(6) motile cells/mL). The sensitivities were 80% for the methylene green, 68% for the resazurin to pink, and 60% for the resazurin to colorless tests. The specificities were 80% for the methylene green, 79% for the resazurin to pink, and 92% for the resazurin to colorless tests. The overall accuracies were 80% for the methylene green test, 74% for the resazurin to pink test, and 76% for the resazurin to colorless tests. The methylene green and resazurin reduction tests can provide valuable information on the fertility potential of an equine semen sample.

Animals↗