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Biomedical subjects

R A Carney

Publications and source records attributed to R A Carney.

4 recordsLinked to original sources
PubMed1995

Patterns of spatial functioning in Turner's syndrome.

This paper presents results from a study of task performance on a variety of spatial tasks in 9-11 year-old children with Turner's Syndrome (T.S.), divided into those with genotype 45XO and those with Mixed genotypes, including isochromosomes of X and mosaicism. There was a significant overall effect of group reflecting impaired spatial cognition in T.S. with greater decrement in the 45XO group. Further investigation of the significant group by task interaction indicated that the group effects appeared on a visuo-perceptual task and on three visuo-constructional tasks but that there were no specific deficits in the T.S. groups on visuo-spatial or tactile-spatial tasks. In T.S., visuo-perceptual and visuo-constructive sub-systems of spatial skill may be more vulnerable than other components of spatial cognition, to the neuro-biological influences which contribute to the disorder. Such dissociation supports theories of modularity in the development of spatial skill. The spatial tasks which create difficulty overlap only partially with those for which there are sex differences amongst normal children and do not represent a simple exaggeration of normal male-female differences.

Child↗
PubMed1993

Intellectual functioning of children with Turner syndrome: a comparison of behavioural phenotypes.

This study reports the results of 19 girls with Turner syndrome (TS), aged between nine and 12 years, in relation to intellectual profile and genotypic variation. The results were consistent with the notion that the behavioural phenotype of mixed TS involving predominantly mosaic karyotypes is less deviant from the normal pattern than that of pure 45XO. The results for the pure TS girls were consistent with an exaggeration of a normal sex difference, but for mixed TS girls this effect was task-dependent. There was no evidence of generalised deficiency or immaturity, and the task-specific effects support modularity in the development of components of cognitive skill and spatial ability. They also support a specific overall intellectual profile in TS, but with considerable inter-individual variation in its expression.

Child↗