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Biomedical subjects

R A Bradley

Publications and source records attributed to R A Bradley.

6 recordsLinked to original sources
PubMed1986

Automated leukocyte differentials in trisomy 13.

We have reported a case of a 4-month-old girl who died with trisomy 13. Nuclear projections in polymorphonuclear leukocytes are diagnostically important in this syndrome and are not identified by automated leukocyte differential counting. The presence of polymorphonuclear leukocyte nuclear projections on the blood smear was identified only after the results of karyotyping were known. Recently, the importance of physician review of blood smears in anemia has been challenged. We believe this case, however, reaffirms the importance of physician blood smear review in suspected cytogenetic disease.

Adult↗
PubMed1984

General approach to bacterial nutrition: growth factor requirements of Moraxella nonliquefaciens.

A general procedure was devised for the determination of growth factor requirements of heterotrophic bacteria based upon identification of individual nutrients as they are successively depleted from a limited quantity of complex medium. By using this approach, it was possible to develop a defined medium for growth of Moraxella nonliquefaciens that contained nine amino acids and three vitamins. Three of the amino acids, proline, serine, and cysteine, were required in unusually high concentrations to obtain optimal growth. Methionine had a sparing action on the requirements for serine and cysteine. Glycine could substitute for serine. Although a required nutrient, cysteine was inhibitory for growth, but this inhibitory action was antagonized by valine or leucine. The requirement for cysteine was satisfied by cystine, glutathione, or sodium sulfide. M. nonliquefaciens could not use ammonia as a nitrogen source but could use glutamate or aspartate for this purpose. With the exception of 1 auxotrophic strain, the growth factor requirements of 23 independently isolated strains of M. nonliquefaciens were essentially the same.

Amino Acids↗
PubMed1976

Science, statistics, and paired comparisons.

A prologue on science and statistics focuses attention on the role of statistics in science. Statisticians must be trained as scientists and to meet the needs of science. Those needs surely involve the formulation, modification and verification of stochastic models designed to represent natural phenomena. The method of paired comparisons provides a simple experimental technique but one with a literature rich in model development.

Mathematics↗