Biomedical subjects
Publications and source records attributed to R A Bergman.
An unusual combination of variations is described in a palmaris longus muscle. The muscle was completely doubled with a tendinous cross slip. Insertion was on the hypothenar and thenar fasciae, and carpal bones. One of the 2 tendons formed the origin of an accessorius ad flexorem minimi digiti muscle.
A child is reported with Behcet's disease who presented with skin and joint manifestations, oral ulcers, brainstem syndrome and neurogenic muscular atrophy. The neurogenic muscular atrophy was confirmed by electrophysiologic, histologic and histochemical studies. Electron microscopy of muscle showed a vasculopathy. The possible etiology of the muscle lesions is discussed. The relevant literature on muscle and peripheral nerve involvement in Behcet's disease is reviewed. It is proposed that neuromyopathy be added to the neurological manifestations of Behcet's disease. To our knowledge, this is the first case of neurogenic atrophy reported in Behcet's disease.
The light and electron microscopic myopathologic and dermatopathologic features in one patient with the partial (localized) type of lipodystrophy are described. The myopathologic changes involve both the contractile elements and the intracellular organelles, especially mitochondria that show hyperplasia and structural alterations of cristae. The dermatopathologic changes consist of a reduction in subcutaneous fat, intercellular edema, and the presence of intracytoplasmic lipid droplets. This is the first report in the literature in which the myopathologic features and detailed electron microscopy of skin in this condition are described. The myopathologic features of partial lipodystrophy are compared with those of congenital generalized lipodystrophy. It is proposed that a myopathy may be one of the manifestations of partial lipodystrophy.
An aberrant psoas major muscle fascicle is described in a human male cadaver. It arose by a tendinous arch spanning the body of L4 and the transverse process of L5, ran an independent course along the pelvic brim to blend with psoas major fibers proximal to the inguinal ligament.
In this report, the temporal sequence of myopathology during a clofibrate-induced muscular syndrome and its recovery in rats is described using histopathologic, histochemical and electron microscopic technics. Two stages of myopathology are described: an early stage characterized by myopathic features, and a later stage characterized by neurogenic features. Although muscle histology returns to normal after 1 week of discontinuing the drug, electron microscopic abnormalities persist through the second week. It is proposed that clofibrate, in addition to its myotoxic effect, may be neurotoxic.
The morphological changes in the sarcomeres of frog sartorii lightly loaded with 25 times muscle weight and fixed in the inactive and in the actively contracting states were studied in longitudinal electron micrographs. The sarcomere in actively contracting muscles, but not in the inactive ones, assumed a distinctive double-concave shape which was due to the bowing-out of the thick myofilaments distal ends at the contraction bands. The drop in tension in extremely shortened muscles was explained on the basis of this behavior.
The morphological changes in the sarcomeres of frog sartorii heavily loaded with 600 times muscle weight and fixed in the inactive and in the actively contracting states were studied in longitudinal electron micrographs. The sarcomere in actively contracting muscles, but not in the inactive ones, assumed a distinctive barrel shape which was referrable to the interaction of thick myofilaments distal ends, normally beyond interaction range because of their tapered structure, with thin myofilaments in an attempt to generate maximal force.
The structural configuration of passive and contracted sarcomeres from frog sartorius muscle was determined for sarcomere lengths between 1.4 and 3.07 microns. Sarcomeres fixed with glutaraldehyde, without detectable contractile activity, were invariably rectangular in shape in longitudinal section regardless of sarcomere length. The structure of sarcomeres excited by osmium tetroxide and contracted depended upon sarcomere length. For lengths greater than 1.6 microns, longitudinally sectioned sarcomeres were convexoconvex (or barrel-shaped). At 1.6 microns, contracted sarcomeres were invariably rectangular in shape. Below 1.6 microns, sarcomeres were compressed and appeared concavoconcave. The results of this study provide models for isovolumetrically contracted sarcomeres which differ significantly from those previously reported.
The clinical and laboratory profiles of 130 cases of muscular dystrophy in Lebanon collected over 35 years (1947-1982) are presented. Data collection included hospital records; registries in the department of pathology, hospital laboratories, electron microscopy facility and electromyography laboratory; and records from a private hospital neurosurgical unit. The yield from each of these sources is presented. The data was fed into an Apple II computer and analyzed using thirty seven parameters. The results are discussed and compared with three other similar studies from India and America.
Pituitary thyrotropin excess resulting in hyperthyroidism has been previously reported in only 25 patients, of whom 19 had a pituitary tumour. This report describes a patient in whom a thyrotropin-producing pituitary tumour was associated with triiodothyronine thyrotoxicosis. Hypophysectomy was followed by a prompt fall in serum thyrotropin and a return to a euthyroid state.
Biopsies of muscle from ten patients and of muscle and nerve from three monkeys were obtained during periods of continuous ischemia and studied by light and electron microscopy and by histochemical means. Between the third and fourth hours of ischemia, swelling of the mitochondria was noted in monkey muscle. One week later the appearance was normal. In the monkey nerves degenerated myelin was seen one week later but appeared to be normal at 2 weeks. If after 3 hours the tourniquet was deflated for 30 minutes and then reapplied for 2 additional hours, no changes were found. Succinic dehyrogenase analysis was used to identify swelling of the mitochondria. No mitochondrial changes were seen in human muscle made ischemic by a tourniquet for 2 hours.
Explore the source record for details and available documents.
Five carriers of the gene of Duchenne type muscular dystrophy are described. Muscle histology was minimally to moderately abnormal in two and normal in three. Electron microscopy was abnormal in all five and showed massive aggregates of subsarcolemmal mitochondria, paracrystalline mitochondria, Z line streaming, central nuclei, dilated sacs of sarcoplasmic reticulum, focal loss of myofilaments, and lipid lysosome bodies. The electron microscopic literature on the carrier state is reviewed and analysed. The possible role of electron microscopy in detection of carriers is discussed.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.