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Biomedical subjects

Q Zhang

Publications and source records attributed to Q Zhang.

At least 649 records · Page 36Linked to original sources
PubMed1997

[CT diagnosis of maxillary sinus diseases].

To evaluate the diagnostic value of CT scan in maxillary sinus diseases, CT findings in 100 cases of maxillary sinus diseases, which included 64 inflammatory diseases; 14 benign tumors; 17 malignant tumors and 5 fractures The result showed that the accordance rate between CT scan and operative diagnosis was 95.0%; between CT scan and pathology was 92.6%(88/95). It is concluded that CT scan showed a better visualization of maxillary sinus than X-ray tomogram.

Adolescent↗
PubMed1997

[Study of estrogen receptors in hepatocellular carcinoma and its response to anti-estrogen therapy].

OBJECTIVE: To study the usefulness of anti-estrogen therapy for moderately and advanced hepatocellular carcinoma (HCC). METHODS: Estrogen receptors (ER) were examined in 51 cases of HCC by immunohistochemical staining of needle aspiration biopsy HCC specimens. The cases studied were randomly divided into two groups: the control group (N = 25) and the anti-estrogen treated group (N = 26). Patients in the control group were given matelin and immune RNA while those in the anti-estrogen treated group were given Tamoxifen in addition. A 50% reduction of serum AFP level and a 50% decrease in tumor size were considered therapeutically effective. RESULTS: In the control group, the response rate as judged by AFP level (RR-AFP) and by tumor size (RR-TS) in the ER+ patients was 42.9% (3 of 7 cases) and 14.3% (1 of 7 cases), respectively, while the 2 RRs in the ER- patients were lower but the difference was statistically insignificant. In contrast, in the Tamoxifen-treated group, RR-AFP was 83.3% (5 of 6 cases) and RR-TS was 50.0% (3 of 6 cases). The difference in RRs of ER+ patients in the 2 groups was statistically significant. No complete remission was observed. CONCLUSION: Endocrinotherapy may be of value in the treatment of ER+ HCC.

Adult↗
PubMed1997

[Long-term results of preoperative chemotherapy for operable breast cancer].

OBJECTIVE: To evaluate the long-term therapeutic results of preoperative chemotherapy for operable breast cancer. METHODS: Patients were divided into preoperative chemotherapy group (group A, 253 cases) and postoperative adjuvant chemotherapy group(group B, 284 cases). The group A patients received preoperative chemotherapy for 4 weeks, followed by radical operation two weeks after chemotherapy. Postoperative adjuvant chemotherapy began within 2 weeks after surgery, with the same chemotherapeutic regimen for 6 or more cycles in both groups. RESULTS: (1) The 5-year overall survival rate (OS) and disease-free survival rate(DFS) were 59% and 54.9%, respectively, for group A in stage III, which were higher than those of group B(28.3% and 20.8%, P < 0.05). (2) For group A in stage II and III, the 8-year OS were 81.4% and 46.9%, and DFS were 76.3% and 40.6%, respectively, which were higher than those of group B(OS: 67.4% and 20.7%, DFS: 62.9% and 13.3%, P < 0.05). (3) The 5-year and 8-year OS were higher for group A than those for group B in patients with T3, T4 or positive nodes > or = 4, (P < 0.05). CONCLUSION: The results show that preoperative chemotherapy can improve the short- and long-term survival of patients with operable, stage III breast cancer and long-term survival of patients with stage II breast cancer.

Adult↗
PubMed1997

[Comprehensive treatment of bone metastases of breast cancer: a clinical analysis of 70 cases].

OBJECTIVE: Bone metastasis is common in breast cancer patients and its main symptom is bone pain. A series of methods were tried to relieve bone pain and to improve quality of life. METHODS: 70 cases of bone metastases of breast cancer were divided into 2 groups and treated with either chemotherapy, radiotherapy, endocrine therapy or isotope therapy alone or in combination. RESULTS: Endocrine therapy or isotope therapy given alone was more responsive than chemotherapy or radiotherapy alone. When the treatment modalities were used comprehensively, the response rate was 90% as compared to 56.4% in patients given single modality treatment (P < 0.01). CONCLUSION: Endocrine or isotope therapy given alone is more effective than chemotherapy or radiotherapy alone. Patients positive for estrogen and progesterone receptors, are more suitable for endocrine therapy. Comprehensive treatment is recommended.

Adenocarcinoma↗
PubMed1997

[Damage-loss relationships and integrated control of 3rd instar larvae of Actias selene nigpoana Felder in planting area of Cornus officinalis Sieb. et Zucc].

In the present paper, the damage-loss model of Actias selene ningpoana to Cornus officinalis was tested and the results indicated that the yield loss rates obeyed the equation Y = 100 - EXP(4.6042 - 0.0315X). The economic threshold of the 2hd and 3rd instar larvae of A. selene nigpoana was then determined as 22 and 8 insects per tree respecitively. Suggestions for integrated control have been made based on the research of activities of A. selene ningpoana in the forest.

Animals↗
PubMed1997

Exon-by-exon screening for RB germline mutations using Heteroduplex-SSCP analysis.

OBJECTIVE: To disclose the nature of RB1 germline mutations in Chinese and to develop a practical and effective way for mutational screening. METHODS: Leukocyte DNA was prepared from 8 Chinese patients with hereditary retinoblastoma. PCR combined with nonisotopic heteroduplex-SSCP analysis was used to screen leukocyte DNA for RB1 germline mutations, exon-by-exon, without the use of restriction endonuclease digestion. The mutations were finally identified by sequencing. In order to testify the effectiveness of this method, the same method was used to detect other 17 samples which have been previously analyzed by other methods. RESULTS: Heterozygous germline mutations were detected in the leukocyte DNA of 6 out of 8 Chinese patients: G del/codon 46, T del/codon 131, CAGAA del/codon 257-258, GCAgta-->GCAgca/donor of exon 16, C-->T/codon 661, and C-->T/codon 787. Heteroduplex-SSCP analysis may detect RB1 germline mutations in 68% (17/25) unselected patients, which is more effective than SSCP(56%) or heteroduplex analysis(64%) alone. The corrected RB1 mutation detection rate may be 80% if the samples were previously analyzed by Southern blotting, which is much higher than those reported on literature. CONCLUSION: Mutations involving a few base pairs in RB1 gene are common in Chinese. Heteroduplex-SSCP analysis is more useful and effective than SSCP or heteroduplex analysis alone for the rapid screening for unknown mutations.

Female↗
PubMed1997

[Cloning, expression and purification of the chaperonin GroESL in Escherichia coli].

The DNA fragment encoding the molecular chaperion GroESL was subcloned into high-expression vector pKC220, and the GroESL were high expressed in the E. coli strain harboring the recombinant plasmid by high temperature induction. The amount of the expressed GroEL and GroES protein were about 40% and 15% of the total cellular proteins, respectively. These two subunits were both purified from E. coli by (NH4)2SO4 salt out DEAE-52 chromography and Sephadex G-50 chromography.

Bacterial Proteins↗
PubMed1997

[Effect of body position changes and circadian rhythm on cerebral blood flow velocity].

To study the effects of -6 degrees head down tilt (HDT), upright posture and 24 h circadian rhythm on cerebral blood flow (CBF) velocity in humans, the CBF velocity was measured by use of transcranial Doppler technique in the middle cerebral artery (MCA) of 12 healthy male subjects. The results showed that the mean CBF velocity increased significantly during -6 degrees HDT and decreased during upright posture, and CBF velocity was higher in day time than at night.

Blood Flow Velocity↗
PubMed1997

Gravitation model for the magnitude of migration and its application.

"The magnitude of migration is one part of the feasibility study on migration, its result being critical to the yield of positive or negative effect.... The key to the success of migration is that the magnitude of migration must be limited within the capacity of the place of destination with generous room for flexibility. It is therefore necessary to determine the appropriate magnitude by scientific methods." The geographical focus is on China.

Asia↗
PubMed1997

[Content determination of total coumarin of qian-hu].

The total content of coumarin in Qian-Hu was determined by UV spectrometry. The 25 samples which derived from different places of production were included eleven varieties. The results were found to have max = 322 nm, 99.18% of recovery rate and 2.08% of RSD.

Coumarins↗
PubMed1997

[Studies on chemical constituents of the essential oil from Angelica formosana].

Essential oil from Angelica formosana Boiss was obtained by steam distillation. The chemical components of the oil were examined by means of capillary gas chromatography and gas chromatography-mass spectrometry. 23 of the 62 separated constituents were identified. The content of each component identified was determined by area normalization method. Of these, the content of 11 compounds was higher than 1%.

Angelica↗
PubMed1997

[Studies on the antilipid peroxidation of nine sorts of Chinese herbal medicines with the function of protecting liver].

The antilipid peroxidation of nine sorts of Chinese herbal medicines with the function of protecting liver, including Salivia miltiorrhiza, Hypericum japonicum, Scutellaria baicalensis, Callicarpa cathayana, Chrysanthemum indicum, Paeonia latiflora, Lysimachia christinae, Ligustrum lucidum (L1), Patrinia villosa (Pv) on hepatic homogenate of rat were tested. It was found that all tested medicines showed inhibition with dose-effect relationship, the inhibitory rate of L1 and Pv were lower than the other's. All results showed that these Chinese herbal medicines have strong antilipid peroxidation and are natural oxidation inhibitor. It was suggested that their function of protecting liver and others have relationship with the antioxidation.

Animals↗
PubMed1997

[Cloning and permanent expression in eukaryotic cells of rhTpo].

OBJECTIVE: To obtain recombinant human thrombopoietin (rhTpo). METHODS: rhTpo gene was cloned from fetal liver mRNA by means of RT-PCR and subcloned into permanent expressing plasmid RC/CMV in order to form a recombinant permanent expressing plasmid RC/CMV/Tpo. RESULTS AND CONCLUSION: After being transferred into CHO cells, the eukaryotic permanent expression of rhTpo, which can enhance murine megakaryocyte colony growth in vitro, was obtained.

Animals↗