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Biomedical subjects

Q Niu

Publications and source records attributed to Q Niu.

At least 19 recordsLinked to original sources

Semiclassical spin transport in spin-orbit-coupled bands.

Motivated by recent interest in novel spintronics effects, we develop a semiclassical theory of spin transport that is valid for spin-orbit coupled bands. Aside from the obvious convective term in which the average spin is transported at the wave packet group velocity, the spin current has additional contributions from the wave packet's spin and torque dipole moments. Electric field corrections to the group velocity and carrier spin contribute to the convective term. Summing all terms we obtain an expression for the intrinsic spin-Hall conductivity of a hole-doped semiconductor, which agrees with the Kubo formula prediction for the same quantity. We discuss the calculation of spin accumulation, which illustrates the importance of the torque dipole near the boundary of the system.

Journal Article↗

Universal intrinsic spin Hall effect.

We describe a new effect in semiconductor spintronics that leads to dissipationless spin currents in paramagnetic spin-orbit coupled systems. We argue that in a high-mobility two-dimensional electron system with substantial Rashba spin-orbit coupling, a spin current that flows perpendicular to the charge current is intrinsic. In the usual case where both spin-orbit split bands are occupied, the intrinsic spin-Hall conductivity has a universal value for zero quasiparticle spectral broadening.

Journal Article↗

Metallic phase in quantum Hall systems due to inter-Landau-band mixing.

The electronic eigenstates of a quantum Hall (QH) system are chiral states. Strong inter-Landau-band mixings among these states can occur when the bandwidth is comparable to the spacing of two adjacent Landau bands. We show that mixing of localized states with opposite chirality can delocalize electronic states. Based on numerical results, we propose the existence of a metallic phase between two adjacent QH phases and between a QH phase and the insulating phase. This result is consistent with nonscaling behaviors observed in recent experiments on a quantum Hall liquid-to-insulator transition.

Journal Article↗

An evaluation of the colorimetric assays based on enzymatic reactions used in the measurement of human natural cytotoxicity.

In recent years colorimetric assays based on an enzymatic reaction such as the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay have been used in an attempt to replace the conventional isotopic assay for cell-mediated cytotoxicity. To clarify the problems in the colorimetric assays for natural cytotoxicity, K562 cells were employed as target cells and peripheral mononuclear cells (PBMCs) from cancer patients were used as effector cells. No correlation was found between the 51Cr assay and the MTT assay (P>0.05) or the N-acetyl-beta-D-glycosaminidase (NAG) release assay (P>0.05) in 16 cancer patients. Labeling effector cells showed that the 51Cr release levels of such cells in 19 chemotherapy patients were significantly higher than the levels from target cells in this group (P<0.01) and from effector cells in the control group (P<0.01). There was no correlation between the positive and negative 51Cr assays (P>0.05). The sensitivity of the MTT assay was greatly decreased by washing K562 cells prior to loading MTT solution. Enzyme release occurs as a result of cell metabolism and elevated enzyme release is associated with freezing. These findings indicate that the colorimetric assays based on an enzymatic reaction are not suitable for the detection of natural cytotoxicity in all populations, and are especially not suitable for the assay of natural cytotoxicity in chemotherapy patients.

Chromium Radioisotopes↗

Shape of the quantum diffusion front.

We show that quantum diffusion has well-defined front shape. After an initial transient, the wave packet front (tails) is described by a stretched exponential P(x,t) = A(t)exp(-absolute value of [x/w](gamma)), with 1 < gamma < infinity, where w(t) is the spreading width which scales as w(t) approximately t(beta), with 0 < beta < or = 1. The two exponents satisfy the universal relation gamma = 1/(1-beta). We demonstrate these results through numerical work on one-dimensional quasiperiodic systems and the three-dimensional Anderson model of disorder. We provide an analytical derivation of these relations by using the memory function formalism of quantum dynamics. Furthermore, we present an application to experimental results for the quantum kicked rotor.

Journal Article↗

Trichloroethylene in urine as biological exposure index.

Occupational exposure to trichloroethylene (TRI) was studied by analysis of environmental air and urine from 49 workers operating in a special printing house on glass. For the measurement of environmental concentration of TRI (Cenv), the ambient air was sampled using personal passive dosimeters. The activated charcoal was desorbed with carbon disulfide and injected into a gas-cromatograph - mass spectrometer (GC-MSD). The biological monitoring of exposed workers was conducted by determining the concentration of TRI in urine (Curine) Urine concentration of TRI was determined by headspace analysis using GC-MSD. Significant correlation was found between the environmental TRI concentration and urinary TRI concentration. The use of a regression equation between Curine (microg/l) and Cenv (mg/m3) (Curine = 0.081 x Cenv + 4.27) resulted in a value of Curine corresponding to Threshold Limit Value-Time Weighted Average (TLV-TWA) exposure value (269 mg/m3) of 26.0 microg/L.

Adult↗

[Effect on manganese exposure on blood prolactin and plasma renin activity].

In order to study the adverse effects of manganese on neuro-endocrine and cardiovascular system, radioimmunoassay (RIA) was used to test the blood prolactin concentration and plasma renin activity among manganese-exposed workers. The result showed that the blood prolactin concentration and Plasma renin activity in manganese exposed workers were significantly higher than those of control group. It suggested that manganese exposure might affect the function at tubero-infundibular area and renin-angiotensin aldosterone system.

Adult↗

[Relationship between serum matrix metalloproteinase-2 and metastasis and recurrence following radical hepatic resection in hepatocellular carcinoma].

OBJECTIVE: To study the relationship between serum matrix metalloproteinase-2 (MMP-2) and metastasis and recurrence following radical hepatic resection in hepatocellular carcinoma (HCC). METHODS: Cox's proportional hazard model was used to determine the significant clinical factor of prognosis. Meanwhile, enzyme linked immunoadsordent assay (ELISA) and northern blot analysis were adopted to detect serum and tumor tissue levels of MMP-2 respectively in HCC patients. RESULTS: Cox's proportional hazard model showed that tumor size and tumor number were significant prognostic factors of HCC patients following hepatic resection (P=0.022 and P=0.040). According to this result, we divided HCC patients into high-tendency to metastasis recurrence and low-tendency to metastasis recurrence groups. Serum levels of MMP-2 in high-tendency to metastasis recurrence following radical hepatic resection group were significantly higher than those in low-tendency group (26.39ng/m+/-2.64ng/ml vs 24.86ng+/-1.95ng/ml, P<0.05). Serum levels of MMP-2 in HCC patients performed non-radical hepatic resection group were also significantly higher than those in HCC patients performed radical hepatic resection group (29.43ng+/-3.12 ng/ml vs 25.72ng+/-2.45ng/ml, P<0.01). Northern blot analysis revealed that the changes of MMP-2 level in the serum were consistent with those of its mRNA level in the tumor tissue of HCC patients. CONCLUSIONS: Serum MMP-2 level is an indicator for metastatic recurrence following radical hepatic resection in HCC. The high levels of MMP-2 in the serum are due to high MMP-2 mRNA expression in the tumor tissue of HCC patients.

Carcinoma, Hepatocellular↗

[Cytokines in experimental cancer cachexia].

OBJECTIVE: To investigate the relationship between cytokine IL-6, IL-1, TNF-alpha and experimental cancer cachexia as well as observe the effect of indomethacin on the cachectic mice. METHODS: T739 mice bearing lung adenocarcinoma LA795 were used as murine tumor cachexia model. In this experiment, serum IL-6, IL-1, TNF-alpha, glucose, protein and triglyceride levels and body weight in different stages of cancer cachexia were monitored. Thirty-two mice were randomized into four groups for comparison, with eight mice in each group: no tumor (NTB) group, tumor without treatment (NT) group, tumor with normal saline (NST) group and tumor with indomethacin (INDT) group. For the last group, intraperitoneal infusion of indothacin 1 microgram/gm was given once every day for six days starting from the 14 th day of tumor implantation. RESULTS: Compared with the NTB group, the NT group showed higher serum of IL-6, IL-1, TNF-alpha and lower total protein, triglyceride and glucose (P < 0.01). After treatment with indomethacin, the INDT mice gave higher serum glucose, protein and lipid levels. Meanwhile, the serum level of IL-6, TNF-alpha and IL-1 in the INDT group was found to be significantly low in comparison with the NST group. CONCLUSION: (1) IL-6, IL-1 and TNF-alpha appear to be involved in experimental cancer cachexia. (2) The positive effects of indomethacin by inhibiting the growth of these cytokines indicate that indomethacin is able to improve the condition of cancer cachexia.

Adenocarcinoma↗

Effect of circular motion exercise on bone modeling and bone mass in young rats: an animal model of isometric exercise.

The aims of the study are to develop a non-invasive animal model of circular motion exercise and to evaluate the effect of this type of exercise on bone turnover in young rats. The circular motion exercise simulates isometric exercise using an orbital shaker that oscillates at a frequency of 50 Hz and is capable of speeds from 0-400 rpm. A cage is fixed on top of the shaker and the animals are placed inside. When the shaker is turned on, the oscillatory movement should encourage the animals to hold on to the cage and use various muscle forces to stabilize themselves. Rats at 8 weeks of age were trained on the shaker for 6 weeks and static and dynamic histomorphometric analyses were performed for the proximal tibial metaphysis and the tibial shaft. The exercise resulted in no significant effect on animal body weight, gastrocnemius muscle weight and femoral weight. Although the bone formation rate of cancellous and cortical periosteum was increased by the exercise, trabecular bone volume was decreased. The exercise increased periosteal and marrow perimeters and the cross-sectional diameter of cortical bone from medial to lateral without a significant increase in the cortical bone area. These results suggest that circular motion exercise under force without movement or additional weight loading will cause bone-modeling drift with an increase in bone turnover to reconstruct bone shape in adaptation to the demand in strength. Since there is no additional weight loading during circular motion exercise, the net mass of bone is not increased. The bone mass lost in trabecular bone could possibly be due to a re-distribution of mineral to the cortical bone.

Journal Article↗

Steering an eigenstate to a destination

The control of time evolution of a quantum state under various physical constraints is investigated and solved in the context of a two-level system. We have discovered a general scheme of steering an eigenenergy state to a destination without net nonadiabatic transitions, and we discuss how the result may be tested and utilized in practice.

Journal Article↗

Morphological symmetry breaking during epitaxial growth at grazing incidence

It is shown that, in submonolayer growth at off-normal incidence, even much less than 1% of transfer from the condensation energy of the deposited atoms into adatom motion is sufficient to induce a net adatom current from the illuminated edge of a two-dimensional island to the other edges, thereby breaking the island symmetry. Such a symmetry breaking phenomenon is most pronounced for deposition at grazing incidence. Comparison between our theoretical predictions and existing experimental results confirms the general validity of the model.

Journal Article↗

Nonlinear effects in interference of bose-einstein condensates

Nonlinear effects in the interference of Bose-Einstein condensates are studied using exact solutions of the one-dimensional nonlinear Schrodinger equation, which is applicable when the lateral motion is confined or negligible. With the inverse scattering method, the interference pattern is studied as a scattering problem with the linear Schrodinger equation, whose potential is profiled by the initial density distribution of the condensates. Our theory not only provides an analytical framework for quantitative predictions for the one-dimensional case, it also gives an intuitive understanding of some mysterious features of the interference patterns observed in experiments and numerical simulations.

Journal Article↗

Dynamical localization of ultracold sodium atoms.

We report a study of atomic motion in time-dependent optical potentials. We measure momentum transfer in parameter regimes for which the classical dynamics are chaotic, and observe the quantum suppression of chaos by dynamical localization. The high degree of control over the experimental parameters enables detailed comparisons with theoretical predictions, and opens new avenues for investigating quantum chaos.

Journal Article↗

[Assessment for effect of low level lead-exposure on neurobehavior in workers of printing house].

WHO Neurobehavioral Core Test Battery (NCTB) was conducted among 28 lead-exposed workers (mean age 24.84, SD2.85) in printing house and 46 controls (mean age 22.78, SD1.45), in order to assess whether low level lead exposure may be related to neurobehavioral dysfunction. The items of test were: 1. Profile of mood state(POMS), (2) Simple reaction time, (3) Digit span, (4) Santa Anna manual dexterity, (5) Digit simbol, (6) Benton visual retention; and Prusuit aiming test. In all the NCTB test values, there was no significant difference between two groups. Multiple stepwise regression analysis shows that exposure duration is related to neurobehavior scores. Mild lead exposure may affect neurobehavior in some degree but not significant.

Adult↗

Proto-oncogene PML controls genes devoted to MHC class I antigen presentation.

Fragments of foreign antigens associated with class I molecules of the major histocompatibility complex (MHC) are presented at the cell surface to elicit an immune response. This presentation requires the coordinated expression of several genes contained in the MHC, including those encoding the MHC class I heavy chain, the proteins LMP-2 and LMP-7, which are involved in the proteasomal degradation of cytosolic antigens into peptide fragments that are destined for association with MHC class I molecules, and TAP-1 and TAP-2, which transport these fragments across the membrane of the endoplasmic reticulum at the start of their journey to the cell surface. In many virus-transformed cell lines and spontaneous tumours, these genes are simultaneously repressed. However, the key factor(s) that are essential for their expression and repression have not been identified. Here we report that the proto-oncogene product PML induces expression of LMP-2, LMP-7, TAP-1 and TAP-2 in an MHC-class I-negative, recurrent tumour, leading to the re-expression of cell-surface MHC in tumours and to rejection of the tumours. PML also regulates MHC expression in untransformed fibroblasts. We conclude that malfunction of PML may enable a tumour to evade the immune defence of its host.

3T3 Cells↗

Expression and cytogenetic localization of the human SM22 gene (TAGLN).

SM22 is a 22-kDa protein identified variously as SM22, transgelin, WS3-10, or mouse p27. Though its precise function is unknown, it is abundant in smooth muscle and so may contribute to the physiology of this widespread tissue. We found that cosmid 16b6 contains the entire 5.4-kb, five-exon human SM22 gene (HGMW-approved symbol, TAGLN), and we cytogenetically localized the gene to chromosome 11q23.2. Northern analysis of human adult tissues showed that SM22 mRNA is most prevalent in smooth muscle-containing tissues, but is also found at lower levels in heart. The human SM22 promoter contains nuclear factor-binding motifs known to regulate transcription in smooth muscle, and human SM22 promoter-luciferase reporter constructs exhibited high transcriptional activity in A7r5 or primary canine aortic smooth muscle cells, but show little activity in nonmuscle COS7 cells. In addition, human SM22 promoter activity increased by two- to threefold upon serum stimulation of nonmuscle cells.

Adult↗

[Study on the changes of heart-rate in lead-exposed workers].

ECG examination and questionnaires survey were performed among lead-exposed workers in order to assess whether moderate occupational lead exposure may cause autonomic nervous system (ANS) dysfunction. The tests included; 1. heart-rate response to Valsalva manoeuvre (HR-V); 2. heart-rate variation during deep breathing (HR-DB); 3. immediate heart-rate response to immediate stand up (30:15 or Max:Min). The results did not show any evidence that lead exposure is related to ANS dysfunction. There was no significant difference between the exposed workers and controls who were with the same ages (P > 0.05). The important cause for ANS dysfunction was aging.

Adult↗