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Biomedical subjects

Prabhakar Pradhan

Publications and source records attributed to Prabhakar Pradhan.

4 recordsLinked to original sources

Circular polarization memory effect in low-coherence enhanced backscattering of light.

We experimentally study the propagation of circularly polarized light in the subdiffusion regime by exploiting enhanced backscattering [(EBS), also known as coherent backscattering] of light under low spatial coherence illumination. We demonstrate for the first time, to the best of our knowledge, that a circular polarization memory effect exists in EBS over a large range of scatterers' sizes in this regime. We show that low-coherence EBS signals from the helicity preserving and orthogonal helicity channels cross over as the mean free path length of light in media varies, and that the cross point indicates the transition from multiple to double scattering in EBS.

Light↗

Modeling low-coherence enhanced backscattering using Monte Carlo simulation.

Constructive interference between coherent waves traveling time-reversed paths in a random medium gives rise to the enhancement of light scattering observed in directions close to backscattering. This phenomenon is known as enhanced backscattering (EBS). According to diffusion theory, the angular width of an EBS cone is proportional to the ratio of the wavelength of light lambda to the transport mean-free-path length l(s)* of a random medium. In biological media a large l(s)* approximately 0.5-2 mm >> lambda results in an extremely small (approximately 0.001 degrees ) angular width of the EBS cone, making the experimental observation of such narrow peaks difficult. Recently, the feasibility of observing EBS under low spatial coherence illumination (spatial coherence length Lsc << l(s)*) was demonstrated. Low spatial coherence behaves as a spatial filter rejecting longer path lengths and thus resulting in an increase of more than 100 times in the angular width of low coherence EBS (LEBS) cones. However, a conventional diffusion approximation-based model of EBS has not been able to explain such a dramatic increase in LEBS width. We present a photon random walk model of LEBS by using Monte Carlo simulation to elucidate the mechanism accounting for the unprecedented broadening of the LEBS peaks. Typically, the exit angles of the scattered photons are not considered in modeling EBS in the diffusion regime. We show that small exit angles are highly sensitive to low-order scattering, which is crucial for accurate modeling of LEBS. Our results show that the predictions of the model are in excellent agreement with the experimental data.

Animals↗

Origin of low-coherence enhanced backscattering.

The origin of low-coherence enhanced backscattering (EBS) of light in random media when the spatial coherence length of illumination is much smaller than the transport mean free path has been poorly understood. We report that in weakly scattering discrete random media low-coherence EBS originates from time-reversed paths of double scattering. Low spatial coherence illumination dephases the time-reversed waves outside its finite coherence area, which isolates the minimal number of scattering events in EBS from higher-order scattering. Moreover, we show the first experimental evidence that the minimal number of scattering events in EBS is double scattering, which has been hypothesized since the first observation of EBS.

Algorithms↗

Low-coherence enhanced backscattering: review of principles and applications for colon cancer screening.

The phenomenon of enhanced backscattering (EBS) of light, also known as coherent backscattering (CBS) of light, has been the object of intensive investigation in nonbiological media over the last two decades. However, there have been only a few attempts to explore EBS for tissue characterization and diagnosis. We have recently made progress in the EBS measurements in tissue by taking advantage of low spatial coherence illumination, which has led us to the development of low-coherence enhanced backscattering (LEBS) spectroscopy. In this work, we review the current state of research on LEBS. After a brief discussion of the basic principle of EBS and LEBS, we present an overview of the unique features of LEBS for tissue characterization, and show that LEBS enables depth-selective spectroscopic assessment of mucosal tissue. Then, we demonstrate the potential of LEBS spectroscopy for predicting the risk of colon carcinogenesis and colonoscopy-free screening for colorectal cancer (CRC).

Animals↗