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Piotr Lass

Publications and source records attributed to Piotr Lass.

42 records · Page 3Linked to original sources
PubMedDate not supplied

[Cerebral blood flow in patients with various symptoms of hemispatial neglect following ischemic stroke].

BACKGROUND AND PURPOSE: The most common cause of hemispatial neglect (HN) is cerebral infarction. It can be induced by lesions in many different regions of the right hemisphere. The purpose of this article was to determine the prevalence of post-stroke HN, its clinical picture, and neuroanatomical correlates. MATERIAL AND METHODS: Forty-six stroke patients with a focal right-hemisphere lesion were studied. Neglect in visual domain, assessed with a battery of drawing, line bisection and shape cancellation tests, was observed in 20 cases. The single-photon emission-computed tomography (SPECT) images of the brain were obtained with 740 MBq (20 mCi) of Tc-99m-labeled ECD on a triple-headed gamma camera. RESULTS: The most sensitive measure of HN was the cancellation test, which all neglect patients performed poorly. Twelve patients, classified as mildly impaired, showed no significant rightward deviation on line bisection, but they showed left visual neglect on the cancellation test. Reverse dissociation was not noted. Performance on a clock-drawing test revealed HN only in two patients, who showed also evidence of HN on other tests. Thereby, some of the tests seem to be more difficult or more sensitive to impairment. The critical area of perfusion abnormalities in all neglect patients were frontal lobe and striatum on the right. In severe HN, SPECT images evidenced the most extensive hypoperfusion throughout the perisylvian region and subcortical structures of the right hemisphere. Although parietal cortex was affected in patients with moderate to severe HN, it was spared in the rest. CONCLUSIONS: HN was a relatively common symptom of vascular right-hemisphere damage (43% of the patient population). HN was a complex disturbance in terms of its clinical manifestation and neuroimaging correlates. Our findings challenge the classical notion that damage to the parietal cortex is critically associated with HN. Instead, our results support the model attributing hemispatial neglect to a defect in a cortico-striato-thalamo-cortical loop. Also, the present study highlights the usefulness of cerebral blood flow SPECT imaging as a diagnostic aid in the post-stroke deficits of cognition following right-hemisphere damage.

Adult↗
PubMedDate not supplied

[Single photon emission computed tomography (SPECT) for the diagnosis of depressive disorders, neurotic and eating disorders].

AIM: The aim of the study was to estimate usefulness of the single photon emission computed tomography (SPECT) for the diagnostics of the depressive disorders, neurotic and eating disorders, and detect the organic factors and correlation between cerebral hypoperfusion and results of Benton's and Bender's tests. MATERIAL AND METHOD: Study of 43 patients (33 women and 10 men) aged 16--59 years (SD+38, 65 +/- 11, 62) which were examined with single photon emission computed tomography (SPECT) and Benton's and Bender's tests during their treatment in the 1st Department of Psychiatry, Medical University in Gdańsk in the years 2000 to 2003. 30 patients were diagnosed with depression (first depressive episodes--8, recurrent depressive disorders--9, organic depression--13), 8--neurotic disorders and 5--eating disorders. RESULTS AND CONCLUSIONS: SPECT in 38 (88,37%) cases showed hypoperfusion mostly on the left side and in the frontal region. Hypoperfusion in the recurrent depressive disorders was considerably greater (nearly significant) in comparison with the first depressive episodes. The correlation between hypoperfusion and CNS impairment examined with Benton's and Bender's tests was observed. The correlation coefficient of was 0.6845.

Adolescent↗
PubMedDate not supplied

Feline hyperthyroidism. The contribution of nuclear medicine.

This paper overviews the incidence, aetiology, clinical signs and complications of hyperthyroidism in cats as well as the contribution of nuclear medicine in the diagnosis and management of this veterinary disease. Thyroid gland scintigraphy is of particular value in detecting autonomic adenoma in occult cases of fenile hyperthyroidism (FH), particularly when hormone tests are doubtful or conflicting. Also, thyroid scintigraphy is useful in detecting the shape of the thyroid gland, hyperfunctioning accessory or ectopic thyroid tissue, multi-nodular goitre and unilateral or bilateral cold lesions. Quantitative radioiodine uptake measurements of 131I, 123I or 99mTc-pertechnetate are rarely performed. Radioiodine uptake is often examined in occult FH. Radioiodine treatment is considered to be the easiest, the most effective and with fewer complications treatment for FH compared to thyreostatic drugs or surgical treatment. The contribution of nuclear medicine in FH is an interesting challenge for both veterinary and nuclear medicine.

Animals↗
PubMedDate not supplied

[The influence of vascular risk factors and white matter hyperintensities on the degree of motor impairment in Parkinson's disease].

BACKGROUND AND PURPOSE: The aim of the study was to assess the prevalence of vascular risk factors and white matter hyperintensities (WMH) in patients with Parkinson's disease (PD) and its impact on clinical features such as motor impairment. MATERIAL AND METHODS: 60 patients with PD [25 women and 35 men; mean age 68.4 (51-81) years, mean duration of disease 8.4 (1-27) years] with good response to L-Dopa were studied. Besides neurological examination, the degree of motor impairment was evaluated in all patients using UPDRS, Hoehn-Yahr, and Schwab-England scales. All patients underwent MRI to assess the degree of WMH using Age Related White Matter Changes (ARWMC) Wahlund scale. Moreover, the prevalence of classic vascular risk factors included arterial hypertension, diabetes mellitus t. 1 and 2; plasma cholesterol, cardiovascular diseases, alcohol abuse and smoking was assessed. RESULTS: Presence of at least one vascular risk factor was noted in 19 patients (31.7%). No significant differences were found between the groups of patients with and without vascular risk factors with regard to all clinical parameters and total ARWMC score. These factors did not differ between the groups of patients with more than 3 vascular risk factors and other patients. WMH (ARWMC > or =1) occurred in 33 patients (55%). No significant differences in all analysed clinical factors and the total number of vascular risk factors between the groups with (ARWMC > or =1) and without (ARWMC=0) WMH were found. The group of patients with at least one focus with score of 2 in the Wahlund scale did not differ significantly in all analysed clinical parameters from the rest of the patients. CONCLUSIONS: Our data suggest that the severity of WMH and incidence of vascular risk factors are not significantly related with the degree of motor disability in PD.

Aged↗
PubMedDate not supplied

[The stroke variables assessment as a prognostic factor for post-stroke depression with the emphasis on the cerebral SPECT regional blood flow asymmetry].

AIM: The aim of this paper was to assess the risk for depression in a 6-month-long post stroke follow up period as related to the stroke variables (i.e. stroke localisation, haemodynamic parameters). METHOD: The stroke localisation was determined with CT and/or MRI. Subsequently all the examined individuals underwent SPECT examination. The follow up examinations were performed by the consultant psychiatrist in 6, 12 and 24 weeks subsequent to the stroke episode. The depressive episode diagnosis was established on the basis of ICD-10 diagnostic criteria. RESULTS: Only right-handed patients (43 men aged 57.3 +/- 11.6 and 17 women aged 62.5 +/- 14.4) with unilateral brain lesion were examined. 23 subjects (38%) developed depression in the follow-up period. 5 women (29%) and 18 men (ca. 42%) developed a depressive episode. Only one of the observed depressive episodes met ICD-10 criteria for severe depressive episode. 10 patients suffered from moderate depressive episode and 12 subjects exhibited a mild depressive episode. CONCLUSIONS: The results obtained with CT and/or MRI techniques revealed no correlation between the post-stroke depression and stroke lateralisation. However the localisation of the deep brain functional abnormalities revealed with SPECT correlated with the occurrence of the affective disorders as related to the asymmetry in regional blood flow measures.

Adult↗