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Biomedical subjects

Philip A Mackowiak

Publications and source records attributed to Philip A Mackowiak.

17 recordsLinked to original sources
PubMed2006

A mariner with crippling arthritis and bleeding eyes.

A 41-year-old mariner developed acute arthritis affecting his legs more than his arms or hands during a violent storm on his return from the first of four voyages of discovery. He experienced repeated attacks of the arthritis over the ensuing 14 years, which on at least two occasions were accompanied by painful eyes "much affected with bleeding." He died shortly before his 55 birthday "quite paralyzed and bedridden." Who was he, and what was the likely etiology of his disorder?

Arthritis, Reactive↗
PubMed2006

Bagoas.

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Acute Disease↗
PubMed2005

On the origin of American tuberculosis.

After more than a century of debate, it is now firmly established that tuberculosis existed in the New World before the arrival of Columbus. What is not yet known is how or when, exactly, the infection reached the Americas, how it spread from one continent to the other, and whether the pre-Columbian infection was caused by Mycobacterium tuberculosis or Mycobacterium bovis.

Americas↗
PubMed2004

The febrile patient: diagnostic, prognostic and therapeutic considerations.

Although clinicians have long pondered the diagnostic and prognostic implications and the treatment of fever, fundamental questions remain unanswered. The value of the height or pattern of a fever in predicting the etiology or course of the illness causing it is a case in point. Whether fever is ever harmful and should, therefore, be suppressed is another. These controversies and others concerning the febrile patient are the subject of this manuscript.

Analgesics, Non-Narcotic↗
PubMed2004

Death of an Arabian Jew.

A 69-year-old Judean man presents with chronic low-grade fever, pedal edema, and abdominal pain. His condition deteriorates over several weeks with the appearance of shortness and foulness of breath, pruritus, convulsions of every limb, and gangrene of the genitalia. Just before he dies, he orders dozens of the leading men of his kingdom imprisoned and instructs his sister to kill them all after he is gone. Who is he and what is the likely cause of his death?

Famous Persons↗
PubMed2002

Caveat cenans!

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Diagnosis, Differential↗
PubMed2002

Fever: beneficial and detrimental effects of antipyretics.

Although various forms of therapy have been used, since antiquity, to lower the temperature of febrile patients, it is still not known whether the benefits of antipyretic therapy outweigh its risks. Justifications for the use of antipyretic drugs, and the evidence pertaining to these rationales, are examined. Antipyretic therapy in sepsis, and adverse effects of antipyretic medications, are also reviewed.

Analgesics, Non-Narcotic↗
PubMed1998

Benefits and risks of antipyretic therapy.

Physicians have used various forms of antipyretic therapy since antiquity to lower the temperature of febrile patients. Nevertheless, it has yet to be determined whether the benefits of antipyretic therapy outweigh its risks. It is not known, for example, if core temperatures encountered during the febrile state ever reach levels that are intrinsically noxious (and therefore merit antipyretic intervention) or when, if ever, fever's metabolic costs exceed its physiologic benefits, or if the benefits of symptomatic relief afforded by antipyretic drugs consistently exceed their toxicologic cost. Whereas preliminary experimental and clinical observations suggest that antipyretic therapy has the potential to increase the duration and/or severity of certain infections, such data are as yet too fragmentary to draw firm conclusions regarding their validity. Finally, although clinicians have long suspected that bacteremia and other severe infections might induce fevers that are less responsive to antipyretic therapy than are those associated with self-limited infections, this concept has not held up under scientific scrutiny. Thus, despite over 2.5 millennia of clinical experience, important questions regarding the risks and benefits of antipyretic therapy remain to be answered.

Analgesics, Non-Narcotic↗