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Petter Jensen Gjersvik

Publications and source records attributed to Petter Jensen Gjersvik.

10 recordsLinked to original sources
PubMed2003

[Dermatitis herpetiformis].

Dermatitis herpetiformis is characterised by an intensely itchy, chronic, papulovesicular eruption, usually on elbows, knees and buttocks. The diagnosis is based on granular IgA deposits in the dermal papillae in a perilesional skin biopsy analysed by immunofluorescence microscopy. Most patients have subclinical celiac disease; a gluten-free diet is effective in most cases. IgA antibodies against tissue transglutaminase (TG2) may be involved in the pathogenesis of celiac disease with or without dermatitis herpetiformis, and an epidermal transglutaminase (TG3) may be the autoantigen in dermatitis herpetiformis. This article provides a short review intended for the general practitioner of the pathogenesis, diagnosis and treatment of dermatitis herpetiformis.

Celiac Disease↗
PubMed2002

Keratoacanthomas frequently show chromosomal aberrations as assessed by comparative genomic hybridization.

Keratoacanthomas are commonly occurring benign skin lesions localized to sun-exposed areas. They typically develop rapidly and may show cellular atypia and infiltration like cutaneous squamous cell carcinomas, but they finally regress spontaneously. This benign lesion shows a high degree of genetic instability as assessed by comparative genomic hybridization, with 35.7% (25 of 70) of the analyzed lesions harboring chromosomal aberrations. The same frequency of genetic imbalance was found in lesions from immunosuppressed organ transplant recipients (36.4%, 20 of 55) and in patients with keratoacanthomas without immunosuppression (33.3%, five of 15), indicating a common pathway in both situations. Recurrent aberrations, given as a fraction of lesions with aberrations, were gains on 8q (20.0%), 1p and 9q (each 16.0%), and deletions on 3p (20.0%), 9p (20.0%), 19p (20.0%), and 19q (16.0%). Many of the most frequently appearing aberrations in keratoacanthomas were not detected in any of the 10 squamous cell carcinomas analyzed, whereas some aberrations were shared by both types of lesions. Aberrations were found in early and late stages of keratoacanthoma development, indicating a role for genetic instability in the progression as well as involution of keratoacanthomas. There were no significant correlations between cytologic atypia and genetic imbalance, or between degree of infiltration and genetic aberrations, although there was a trend for keratoacanthomas with severe atypia to have aberrations. Thus malignant phenotypic development does not appear to be driven by the detected genetic aberrations. More detailed studies of chromosomal areas with recurrent aberrations are needed for the localization of putative genes that determine the biologic behavior of keratoacanthomas, and that may distinguish them from squamous cell carcinomas.

Carcinoma, Squamous Cell↗
PubMed2002

Use of the Internet among dermatologists in the United Kingdom, Sweden and Norway.

The Internet is increasingly important for doctors in all branches of medicine, but to what extent it is used by dermatologists is not known. In May 2001, we sent a questionnaire by post to 1,291 members of the dermatological societies of the United Kingdom, Sweden, and Norway. Six hundred fifty-three (51%) responded. Excluding those from retired doctors and non-dermatologists, 522 questionnaires were available for analysis. Ninety-five percent of the respondents had access to the Internet, at work (77%) and/or at home (83%). Seventy-nine percent used the world wide web for medical updating and other professional purposes. In a multivariate logistic regression analysis, age and private practice were negative predictors for Internet use (p<0.001). Sixty-two percent found medical databases on the Internet and 25% believed the Internet version of medical journals to be important for their continuing medical education. This may be compared to those who found medical journals on paper(83%), medical meetings(81%), and various forms of contact with peers and colleagues(62-66%) to be so. This study shows that a large proportion of dermatologists, especially younger doctors, use the Internet for medical and educational purposes, but Internet use has not yet replaced traditional ways of obtaining continuing medical education.

Adult↗