Biomedical subjects

Peter L Faries

Publications and source records attributed to Peter L Faries.

At least 55 records · Page 3Linked to original sources

PubMed2003

Radial artery flow-through graft: a new conduit for limb salvage.

OBJECTIVE: Patients with severe peripheral occlusive disease may present especially challenging problems because of previous bypass surgery, location of ulcers, or extremely poor runoff. We used the radial artery with its overlying skin flap as a bypass conduit, called the radial artery flow-through (RAFT) graft in 10 such patients. METHODS: From November 1999 to January 2002, 10 patients had limb-threatening ischemia at presentation. All had severe inframalleolar vascular occlusive disease. Four patients had undergone previous conventional bypass procedures. Two grafts remained patent, but distal ulcers failed to heal. Eight patients were men. Seven patients had diabetes mellitus. All patients but one had nonhealing ulcers. In most cases, a composite femoral-tibial bypass graft was constructed by sewing the RAFT graft end-to-end to either the greater saphenous vein or, in one patient, to a polytetrafluoroethylene graft. In all cases, the radial venous comitans were sewn to a nearby superficial vein. In 5 patients the skin paddle was positioned to cover the ulcer; in the remaining patients the skin paddle was used to close the foot incision over the distal anastamosis. Postoperative graft surveillance was performed with Duplex scanning or contrast medium-enhanced angiography. RESULTS: Thromboses developed in 2 grafts during follow-up. In 1 of these patients below-knee amputation was performed. Another patient required below-knee amputation because of continuing infection in the foot despite a patent RAFT graft. In 1 patient thrombosis developed in the vein graft, but the RAFT graft extension remained patent. All other RAFT grafts were patent in their entirety at 15 (+/-6) months. CONCLUSIONS: The RAFT graft is a new option for treating limb-threatening ischemia. The skin paddle may be useful in selected patients for wound coverage.

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PubMed2003

Mechanical failure of prosthetic human implants: a 10-year experience with aortic stent graft devices.

OBJECTIVE: The first endovascular stent graft was implanted to treat an abdominal aortic aneurysm more than a decade ago. This technique has evolved dramatically with the growing understanding of metallurgic and fabric sciences and improved device designs. However the potential for stent graft material failure remains. This investigation describes the incidence of material failure, potential modes of device fatigue, and the clinical significance of these failures. METHODS: Six hundred eighty-six endovascular stent grafts were used to treat patients with aortic aneurysms. Device fatigue in the form of stent, suture fracture, or graft wear was identified with an analysis of follow-up radiographs and explanted stent grafts. A review of patient clinical histories, spiral computed tomographic scan studies, scanning electron microscopy, and energy dispersion spectroscopy of explanted devices was conducted to evaluate the modes and consequences of failure. RESULTS: Sixty patients were identified with device fatigue, 49 of whom had abdominal endovascular repairs and 11 of whom had thoracic repairs. Of the 60 patients with stent graft fatigue, 43 patients had metallic stent fractures, 14 had suture disruptions, and three had graft holes. These material failures occurred within seven distinct stent graft designs. The average time to the recognition of failure was 19 months, with a mean follow-up period of 8 months since the event was identified. Eleven patients died, and one was lost to follow-up 2 years after identification of a stent fracture. The remaining patients are presently being followed eoyj physical examination, plain film radiograph, and computed tomographic scans for clinical sequelae of device fatigue. CONCLUSION: Endovascular stent graft fatigue has been recognized in numerous devices after aortic implantation. Fatigue may take the form of stent, graft, or suture failure, with certain modes unique to specific stent graft devices. The clinical significance of stent graft material failure remains uncertain.

Aortic Aneurysm↗

PubMed2003

Endovascular aortic biopsy in the diagnosis of takayasu arteritis.

PURPOSE: To use a minimally invasive approach to obtain biopsy specimens of the aorta to confirm the diagnosis of Takayasu arteritis and formulate a therapeutic plan. CASE REPORT: A 17-year-old woman with lower extremity claudication and a normal erythrocyte sedimentation rate had magnetic resonance angiography, which suggested stenotic lesions of the infrarenal aorta and left renal artery. An endovascular biopsy of the aortic lesion was performed under local anesthesia, retrieving sufficient tissue to make the diagnosis of Takayasu arteritis. The patient was discharged the same day. CONCLUSIONS: Endovascular aortic biopsy may be useful in diagnosing Takayasu arteritis and guiding the clinician toward the proper mode of treatment.

Adolescent↗

PubMed2003

Endovascular treatment of abdominal aortic aneurysms.

Minimally invasive endovascular techniques for the treatment of abdominal aortic aneurysm have significantly reduced its morbidity compared to that following standard surgical repair. Moreover, patients with extensive comorbid medical illnesses, for whom standard operative repair is contraindicated may be successfully treated using endovascular means. The full limitations and indications for use of endovascular grafts have not yet been fully defined. The effectiveness of commercially fabricated devices is currently being evaluated. This article describes the general principles of use for endovascular devices for the repair of abdominal aortic aneurysms and details the features of the devices currently in use, as well as the typical results.

Aortic Aneurysm, Abdominal↗

PubMed2002

Vascular smooth muscle cells derived from atherosclerotic human arteries exhibit greater adhesion, migration, and proliferation than venous cells.

BACKGROUND: Phenotypic variation of vascular smooth muscle cells (VSMC) may result in altered biological behavior and responses. Within the vessel wall, arterial VSMC have a greater propensity to form atherosclerotic lesions as compared to venous VSMC. In this study the rates of proliferation, adhesion, and migration were compared between VSMC of atherosclerotic arterial and venous origin. MATERIALS AND METHODS: Human VSMC cultures were isolated from 18 infragenicular arteries at the time of below knee amputation and from 20 saphenous veins during lower extremity revascularization surgery. Cell cultures were isolated from the media of each specimen and maintained in distinct cell lines for all assays. Cells from passages 2 and 3 were assayed for their proliferative capacity using total DNA fluorescence photometry and for adhesion and migration using a modified Boyden chamber. RESULTS: Patient age and the incidence of atherosclerotic risk factors did not vary significantly between the arterial and the venous patient groups. VSMC of atherosclerotic arterial origin demonstrated greater proliferation (arterial, 162 +/- 59 absorption units, vs. venous, 106 +/- 56 absorption units, P < 0.001), adhesion (arterial, 74.1 +/- 22.6 cells/microscopic field, vs. venous, 41.3 +/- 12.8 cells/microscopic field, P < 0.001) and migration (arterial, 427 +/- 185 cells/microscopic field, vs venous, 119 +/- 101 cells/microscopic field, P < 0.001) than VSMC of venous origin. CONCLUSION: Human atherosclerotic arterial VSMC exhibit significantly increased rates of proliferation, adhesion, and migration as compared to human venous VSMC. These observations of VSMC in culture are consistent with the clinical predilection for the hyperplasic responses that result in the development of atherosclerosis in the arterial wall. Possible intrinsic differences in VSMC phenotype should be considered in designing methods to limit atherosclerosis.

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PubMed2002

Endovascular repair of thoracic aortic aneurysms: stent-graft fixation across the aortic arch vessels.

The close proximity of the arch vessels to the origin of many thoracic aortic aneurysms (TAA) may result in placement of the stent struts across the left subclavian or carotid ostia. The purpose of this study is to determine the incidence and impact of transaortic arch vessel fixation during thoracic aortic stent graft deployment for the treatment of descending TAA. From May 1997 to July 2000, 20 patients (10 men, 10 women, mean age 82 years) with descending TAA were treated in the operating room with endoluminally placed stent grafts secured proximally to the thoracic aorta with a long (15-mm) uncovered stent segment (Talent LPS). Pre- and post-operative angiograms and IV contrast-enhanced spiral CT scans were performed in all cases. Follow-up contrast CT scans were obtained at 1, 3, 6, and 12 months and yearly thereafter to assess the adequacy of repair and to determine stent position and arch vessel patency. We found that thoracic aortic endograft fixation across the left aortic arch vessels occurs frequently during device placement and is associated with no early morbidity. Long-term follow-up is necessary to ensure that there are no late sequelae.

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PubMed2002

Endovascular repair of abdominal aortic aneurysms: stent-graft fixation across the visceral arteries.

PURPOSE: Recent studies have suggested that transrenal artery fixation of endovascular stent-grafts is safe and may be a desirable means of reducing the risk of type I endoleaks, particularly those with short infrarenal necks. The close proximity of the superior mesenteric and celiac arteries to the renal arteries may commonly result in the placement of the stent struts across all the vessels of the visceral segment of the aorta. The purpose of this study was to determine the incidence and impact of transvisceral artery fixation during aortic stent-graft deployment for the treatment of abdominal aortic aneurysms (AAAs). METHODS: From January 1997 to June 1999, 192 patients (165 men, 27 women; mean age, 82 years) with AAAs were treated with an endovascular graft secured proximally to the aorta with a long (15 mm) uncovered stent segment (60 Parodi/Palmaz, 132 Talent-LPS). Preoperative and postoperative abdominal aortograms and intravenous contrast enhanced spiral computed tomography (CT) scans were performed. Follow-up CT scans were obtained at 3, 6, and 12 months and yearly thereafter as a means of determining stent position and visceral artery patency RESULTS: In 95 patients (49%), the uncovered stent was at or above the level of the superior mesenteric artery. In 23 patients (12%), the stent extended to the level of the celiac axis. In a mean follow-up period of 25 months (range, 6-44 months), serum creatinine levels remained stable, no stenoses or occlusions occurred in the celiac, superior mesenteric, or renal arteries, and no evidence of renal, hepatic, splenic, or intestinal infarction was present on contrast enhanced spiral CT scans. There were no type I endoleaks. CONCLUSION: Transvisceral fixation of the uncovered proximal aortic stent occurs frequently during deployment of devices designed for transrenal fixation and is associated with no early morbidity. Long-term follow-up is necessary to ensure that there are no late sequelae.

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PubMed2002

A multicenter experience with the Talent endovascular graft for the treatment of abdominal aortic aneurysms.

OBJECTIVE: The Talent endovascular graft has been used in the treatment of abdominal aortic aneurysms (AAAs) in more than 13,000 patients worldwide. However, information regarding the results of its use has been limited. This report describes the experience with 368 patients with AAAs who underwent treatment at four medical centers as part of an investigator-sponsored investigational device exemption trial. METHODS: Patients with AAAs were enrolled at four sites during a 32-month period from January 1999 to July 2001. All patients underwent treatment for infrarenal AAA with the Talent endovascular graft. Repair was performed with transrenal stent fixation under epidural (362/368 patients; 98.3%), local (4/368 patients; 1.1%), or general (2/368 patients; 0.5%) anesthesia. The average diameters were: maximum aortic aneurysm, 6.2 +/- 1.2 cm; proximal aortic fixation site, 2.6 +/- 0.4 cm; and distal iliac fixation site, 1.4 +/- 0.6 cm. Bifurcated grafts were used in 276 of 366 patients (75%), aortouniiliac in 57 of 366 patients (16%), and tube aortoaortic in 33 of 366 patients (9%). Multiple comorbid medical conditions were present in all patients (average, 4.7 conditions/patient). The mean age was 75.8 years, and 85% of the patients were male. Follow-up period ranged from 2 to 33 months (mean, 7.3 months). RESULTS: Endovascular graft deployment was accomplished in 366 of 368 patients. In the 263 patients followed for at least 6 months after endovascular repair, AAA diameter decreased by 5 mm or more in 83 patients (32%); diameter remained unchanged (change < 5 mm) in 157 patients (60%) and increased by 5 mm or more in 23 patients (8.7%). Major morbidity occurred in 46 of 368 patients (12.5%), and minor morbidity occurred in 31 of 368 (8.4%). The 30-day mortality rate was 1.9%. Secondary procedures were performed in 32 patients (8.7%). Late rupture occurred in two patients, and late deaths unrelated to AAA occurred in 32 patients (8.7%) during the follow-up period. The primary technical success rate for all patients was 93.4%. The 30-day primary procedural success rate was 73.3%. The 30-day secondary procedural success rate was significantly higher at 85.8%. Computed tomographic scan was performed within 1 month after surgery in 349 patients. An endoleak was present in 43 of 349 patients (12.3%). These endoleaks were comprised of 10 attachment site (type I; 2.9%), 31 retrograde side-branch (type II; 8.9%), and two transgraft (type III; 0.6%). CONCLUSION: These midterm findings show a high degree of technical and procedural success achieved in a patient population with extensive comorbid medical illnesses with low perioperative morbidity and mortality rates. Further follow-up study will be necessary to determine the effectiveness of the Talent endograft for the long-term treatment of AAA.

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PubMed2002

Failure of endovascular aortoaortic tube grafts: a plea for preferential use of bifurcated grafts.

OBJECTIVE: Aortoaortic tube graft repair was the first technique used for the endovascular treatment of abdominal aortic aneurysms (AAAs). However, progressive changes in the morphology of the distal aortic neck may be responsible for procedural failure. This study examines the use of aortoaortic tube prostheses and analyzes the factors that contributed to their failure and the methods used for their subsequent repair. METHODS: During a 7-year period, 462 patients with abdominal aortic aneurysms underwent endovascular aortic aneurysm repair. Of these, 65 patients (14%) underwent treatment with aortoaortic tube endoprostheses. Aortoaortic tube prostheses used included Talent (n = 44) (Medtronic-Worldmedical, Sunrise, Fla), Vanguard (n = 8) (Boston Scientific, Natick, Mass), EVT/Ancure (n = 4) (Guidant, Menlo Park, Calif), and physician-fabricated (n = 9). All the tube graft procedures were performed in the operating room with fluoroscopic guidance. The average age of patients for aortoaortic tube grafts was 74.5 years, and 48 of the patients were men. Failure was defined as aneurysm expansion, any type I endoleak, or type II endoleak persistent after 6 months. RESULTS: No aneurysm ruptures or perioperative deaths were seen. Retrograde aneurysm perfusion from lumbar or inferior mesenteric arteries (type II endoleak) that persisted beyond 6 months was present in three patients. Proximal attachment site endoleaks were present in two patients. No distal implantation site endoleaks were present within 1 month of the initial endovascular repair; however, endoleaks at the distal attachment site developed in 12 patients subsequently and included all graft types (Talent, n = 6; Vanguard, n = 2; Ancure/EVT, n = 1; physician-fabricated, n = 3). The average time interval to failure was 12.9 months. Preoperative distal aortic neck length showed a significant correlation with the subsequent development of distal endoleak (endoleak, 16.6 +/- 6.8 versus no endoleak, 23.3 +/- 9.6; P =.03). Preoperative distal aortic neck diameter, however, did not show significance (23.8 +/- 5.2 versus 22.6 +/- 4.7; P = not significant). CONCLUSION: Endovascular aortoaortic tube grafts are vulnerable to failure even when initial exclusion of the aneurysm is successful. A significant association is seen between distal neck length and eventual failure. Because of the propensity toward eventual failure, the use of aortoaortic tube grafts in the infrarenal aorta cannot be recommended for typical fusiform aneurysms, even when an adequate distal neck appears to be present.

Aged↗

PubMed2002

Transrenal bare stents in endovascular treatment of abdominal aortic aneurysms.

Endovascular stent-graft (EVSG) repair of abdominal aortic aneurysms (AAA) has continued to evolve since its introduction in 1991. The ability to secure a stent-graft in the suprarenal aorta with an uncovered proximal stent is felt by many to improve the overall fixation of the device and decrease the risk of migration and endoleak. While preliminary evidence suggests that type I endoleaks may be less frequent when transrenal bare stents are used, this has yet to be conclusively shown. Of obvious concern is the risk of renal parenchymal damage or diminished blood flow following placement of a bare stent across the renal artery ostia. Numerous small series have shown little or no risk of significant renal impairment at intermediate length of follow-up after transrenal stent placement. The presence of a stent across the renal artery orifice does not appear to interfere with later interventions on that artery, such as angioplasty and stenting.

Aortic Aneurysm, Abdominal↗

PubMed2002

Endovascular stent-graft treatment of a ruptured thoracic aortic ulcer.

PURPOSE: To describe a ruptured ulcer of the descending thoracic aorta treated with an endovascular stent-graft deployed under transesophageal echocardiographic (TEE) guidance. CASE REPORT: An 82-year-old man with severe chronic obstructive pulmonary disease and congestive heart failure presented with sharp pain in the back radiating to the left flank. Computed tomography (CT) and angiography demonstrated a penetrating ulcer of the descending thoracic aorta associated with aortic dissection commencing 6 cm from the origin of the left subclavian artery with extravasation of contrast outside the aortic wall. The patient remained symptomatic with a decrease in hematocrit from 36% to 23%. Endovascular repair was performed using self-expanding nitinol stents sutured to a 35-mm x 12-cm Dacron conduit. The device was deployed with a 24-F delivery system under TEE guidance and fluoroscopy. Successful exclusion of the ruptured ulcer was demonstrated by TEE Doppler, arteriography, and CT. The patient remains asymptomatic 18 months after the procedure with no CT evidence of endoleak. CONCLUSIONS: Endovascular stent-graft repair under TEE guidance assists in the oftentimes difficult treatment of ruptured penetrating thoracic aortic ulcer.

Aged↗

PubMed2002

Predicting iliac limb occlusions after bifurcated aortic stent grafting: anatomic and device-related causes.

OBJECTIVE: Graft limb occlusion may complicate endovascular abdominal aortic aneurysm repair. The precise etiologic factors that contribute to the development of these graft limb thromboses have not been defined. We evaluated our experience with bifurcated aortic endografts to determine factors that may predict subsequent limb thrombosis. The management of the thrombosed limbs and the results after treatment were also investigated. METHODS: During a 4-year period, 351 patients with aortic aneurysms underwent treatment with bifurcated endografts (702 graft limbs at risk). These 351 bifurcated devices included AneuRx (Medtronic, Minneapolis, Minn; n = 35), Ancure (Guidant, Menlo Park, Calif; n = 8), Gore (W.L. Gore & Associates, Sunnyvale, Calif; n = 25), Talent (World Medical, Sunrise, Fla; n = 255), Teramed (Teramed, Minneapolis, Minn; n = 10), and Vanguard (Boston Scientific Vascular, Natick, Mass; n = 18). Details regarding the type of device, mechanism of deployment, and aortoiliac artery anatomy were collected prospectively and analyzed. Graft limbs were analyzed for diameter, use of additional endograft iliac extensions, deployment in the external iliac artery, and endograft to vessel oversizing. Follow-up included physical examination, duplex ultrasonography, and spiral computed tomographic scans at 1 month, 6 months, and 12 months and annually thereafter. The follow-up period ranged from 2 to 54 months, with a mean follow-up period of 20 months. RESULTS: Twenty-six of 702 limbs (3.7%) had an occlusion develop. The risk of limb thrombosis was associated with a smaller limb diameter. Mean graft limb diameter was 14 mm in the occluded population, and patent limbs had a mean diameter of 16 mm. Thrombosis occurred in 16 of 291 limbs (5.5%) that were 14 mm or less and in 10 of 411 limbs (2.4%) that were greater than 14 mm (P =.03). Extension of a graft to the external iliac artery was performed in 96 of the 702 limbs. Eight of these 96 limbs (8.3%) had thrombosis develop as compared with 18 of 606 (3.0%) that extended to the common iliac artery (P =.01). No significant association was present between limb thrombosis and the contralateral or ipsilateral side of a device, the configuration of the iliac graft limb end (closed web, open web, or bare spring), or the degree of iliac graft limb oversizing. AneuRx, Ancure, Vanguard, and Talent grafts each sustained limb occlusions, with no occlusions seen among the Gore and Teramed devices. No significant increased risk of graft limb thrombosis was observed in unsupported grafts (1/16; 6.3%) versus supported grafts (25/686; 3.6%; P = not significant). Thromboses occurred between 1 day and 23 months after surgery. Thirteen of the 26 thromboses (50%) occurred within 30 days of surgery. Presenting symptoms were mild to moderate claudication in eight patients (30.8%), severe claudication in 16 patient (61.5%), and paresthesia and rest pain in two patients (7.7%). Eighteen of 26 patients (69.2%) eventually needed intervention to reestablish flow to the occluded limb, including thrombolysis and stenting in two patients (7.7%), axillary femoral bypass in one patient (3.8%), femoral-femoral bypass in 13 patients (50.0%), and axillary-bifemoral bypass in two patients (7.7%). All patients with mild to moderate symptoms under observation had improvement in symptoms with no further interventions necessary. All revascularizations were successful in relieving symptoms. CONCLUSION: Graft limb occlusion is a recognized complication of endovascular treatment of abdominal aortic aneurysms that may be associated with smaller graft limb diameter and extension to the external iliac artery. Occlusions usually necessitate additional intervention for resolution of ischemic symptoms. The use of small diameter grafts should be avoided when possible to reduce the risk of graft limb occlusions.

Aortic Aneurysm, Abdominal↗

PubMed2002

Abdominal aortic aneurysmorrhaphy and cholelithiasis in the era of endovascular surgery.

The incidence of acute cholecystitis complicating standard abdominal aortic aneurysm (AAA) repair has been reported between 0.3 and 18 per cent. This has prompted considerable debate regarding the management of cholelithiasis discovered incidentally during open aortic reconstruction. This study seeks to determine the incidence of cholelithiasis and acute cholecystitis after endovascular AAA repair and evaluate options for management. Between February 1996 and October 2001 492 patients underwent endovascular AAA repair. All the procedures were performed in the operating room under fluoroscopic guidance. Epidural (98.9%), local (0.5%), or general (1.7%) anesthesia was used during these cases. The incidence of cholelithiasis and acute cholecystitis was evaluated by CT scan and abdominal ultrasound. Serum measurements of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total and direct bilirubin, and amylase were performed and clinical assessment was conducted at 1, 6, and 12 months postoperatively and annually thereafter. The mean age of these patients was 76.6 years; 84% were male. Comorbid medical conditions were present in all patients (average 3.5 conditions/patient). Follow-up ranged from 2 to 35 months (mean 12.8 months). Endovascular stent graft deployment was successful in 486 of the 492 patients (98.8%). Six patients were converted to standard open repair because of inability to achieve successful endovascular aneurysm repair. The perioperative major morbidity rate was 14.9 per cent. Minor morbidity rate was 8.5 per cent. The perioperative mortality rate was 1.9 per cent. No deaths were related to biliary disease. Cholelithiasis was identified in 64 (13%) patients preoperatively. One of 64 patients with a prior Billroth II reconstruction for peptic ulcer disease developed jaundice 8 days after AAA repair as a result of choledocholithiasis that required surgical repair. One patient without gallstones developed acute acalculous cholecystitis on postoperative day 16 as determined on pathologic analysis of the gallbladder. A third patient who had gallstones identified on preoperative CT scan developed calculous cholecystitis 16 months after endovascular AAA repair. These two patients underwent uncomplicated laparoscopic cholecystectomy and recovered uneventfully. The incidence of postoperative symptomatic cholelithiasis is 1.6 per cent (one of 64). The incidence of postoperative acute cholecystitis was 0.2 per cent (one of 486) and was unrelated to the presence of gallstones. The incidence of delayed symptomatic cholelithiasis was 1.6 per cent (one of 64). Endovascular repair of AAA does not appear to predispose the patient to the development of symptomatic cholelithiasis during the perioperative period. Therefore a preoperative or intraoperative diagnosis of cholelithiasis does not necessitate cholecystectomy in the setting of planned endovascular AAA repair. Patients who develop cholecystitis after endovascular AAA repair may be effectively treated by standard laparoscopic techniques.

Acute Disease↗

PubMed2002

Intentional internal iliac artery occlusion in endovascular repair of abdominal aortic aneurysms.

Endoluminal grafting of aortoiliac aneurysms is an evolving technology. Since many lesions involve part of all of the common iliac arteries, it may be necessary to cover the internal iliac (hypogastric) arteries. Since the internal iliac arteries are important for flow to pelvic organs and perhaps the colon, their sacrifice may not be innocuous, especially since reimplantation of the inferior mesenteric artery is not possible during endovascular aneurysm repair. Most series reflect the relative safety of unilateral internal iliac artery sacrifice. Bilateral hypogastric artery sacrifice, especially if not staged temporally, may cause more significant complications. The incidence of claudication and impotence remains significant, prompting some to recommend revascularization of at least one internal iliac artery at the time of aneurysm repair in order to preserve one of these important vessels. Such an internal iliac artery bypass can be simply performed during endovascular aneurysm repair. The development of larger, more precisely deployed iliac limbs as well as the development of branched devices should decrease the need for internal iliac artery sacrifice.

Angiography↗

PubMedDate not supplied

Rupture of excluded popliteal artery aneurysm: implications for type II endoleaks--a case report.

The fate of popliteal artery aneurysms after ligation and bypass is believed to be relatively innocuous. The patient presented in this report, however, experienced spontaneous rupture of a popliteal aneurysm 11 years after ligation and bypass. Magnetic resonance angiography was used to establish the diagnosis of rupture, which was subsequently confirmed at surgery. Intraoperative arteriography demonstrated persistent collateral arterial perfusion of the excluded popliteal aneurysm sac. The collateral arterial flow originated from the superior and inferior lateral genicular arteries. The persistent arterial perfusion resulted in growth of the aneurysm from 4.2 to 7.0 cm over the 11-year period. The ruptured aneurysm was successfully treated by direct arterial exposure and suture ligation of the collateral vessels performed from within the aneurysm sac. The development of popliteal aneurysm expansion and rupture as a result of collateral arterial perfusion suggests that persistent collateral perfusion of abdominal aortic aneurysms after endovascular repair (type II endoleak) may lead to aneurysm rupture. Therefore, close observation and intervention for aneurysm expansion to prevent rupture of the excluded aneurysm are warranted.

Aged↗

PubMedDate not supplied

Postcarotid endarterectomy pseudoaneurysm treated with combined stent graft and coil embolization--a case report.

Pseudoaneurysm formation is a rare complication following carotid endarterectomy (CEA); however, its occurrence is associated with significant risk of morbidity. The patient in this report presented 2 years following CEA with headache and lateral neck mass. The diagnosis of a 3.5 x 3.0 cm carotid artery bifurcation pseudoaneurysm was made by using magnetic resonance angiography (MRA). Endovascular exclusion of the aneurysm was accomplished with coil embolization of the external carotid artery followed by deployment of a 7 x 50 mm wall stent graft into the common carotid artery-internal carotid artery (CCA-ICA). The patient's symptoms improved and at 6-months postexclusion, duplex ultrasound demonstrated a significant reduction in pseudoaneurysm size. This case highlights the feasibility and safety of using endovascular techniques in the treatment of post-CEA pseudoaneurysm.

Aged↗

PubMedDate not supplied

Endoluminal recanalization in a patient with phlegmasia cerulea dolens using a multimodality approach-a case report.

Phlegmasia cerulea dolens is a limb-threatening form of deep venous thrombosis and should be treated aggressively. The authors report a patient who presented with iliocaval and femoral deep venous thrombosis and posed an additional therapeutic challenge based on a recent history of heparin-induced thrombocytopenia. Catheter-directed pharmacologic thrombolysis and balloon venoplasty were applied in treatment. The direct thrombin inhibitor argatroban was used in place of heparin for concurrent anticoagulation. This multimodality endovascular approach (chemical and mechanical interventions) was successful in relieving the venous occlusion and salvaging the limb, while maintaining appropriate treatment for heparin-induced thrombocytopenia.

Anticoagulants↗

PubMedDate not supplied

Multimodal therapy for acute and chronic venous thrombotic and occlusive disease.

Critical deep venous thrombosis and occlusion constitutes a small percentage of patients with venous disease. However, these patients exhibit severe symptomatology including pain and extensive edema that may progress to limb- or life-threatening complications such as phlegmasia cerulea dolens and superior vena cava syndrome. This paper reviews the different multimodal percutaneous interventions currently available for the treatment of complex critical venous thrombotic and occlusive disease.

Acute Disease↗