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Biomedical subjects

Per Söderberg

Publications and source records attributed to Per Söderberg.

5 recordsLinked to original sources

Reliability of global assessment of functioning ratings made by clinical psychiatric staff.

OBJECTIVE: In the Swedish psychiatric care system, systematic follow-up of clinical work with patients is becoming a part of regular service, and a number of care providers are using the Global Assessment of Functioning (GAF) to measure outcomes. This study investigated the reliability of the GAF and analyzed certain factors that affect measurement errors when the scale is used by regular psychiatric staff. METHODS: Eighty-one raters from various psychiatric outpatient clinics rated eight case vignettes. Interrater reliability was assessed by using intraclass correlation coefficients (ICCs), and factors associated with reliability were analyzed by using raters' unique residual values. RESULTS: The results showed that staff who are responsible for assessing first-time patients at outpatient psychiatric clinics and making diagnoses are using the GAF with satisfactory reliability (ICC(1,1)=.81). The factors associated with reliability were raters' subjective attitude toward the GAF and motivation to use the scale and other measurement instruments in psychiatry. CONCLUSIONS: GAF ratings made by an individual rater can be used to measure changes and outcomes at the group level. However, the measurement error is too large for assessment of change for an individual patient, in which case it might be necessary to use several raters. If raters are positively inclined to use rating instruments, measurement errors are minimized and reliability is maximized.

Diagnostic and Statistical Manual of Mental Disord↗

Relationship between the Global Assessment of Functioning and other DSM axes in routine clinical work.

OBJECTIVES: The aim of this study was to investigate the validity of the Global Assessment of Functioning (GAF) when routinely used in clinical work by focusing on the relations between the GAF, other axes in the DSM system, and some demographic variables conceptually derived on theoretical and clinical grounds. METHODS: A clinical database containing data for 5,538 patients assessed by 181 raters as a part of routine practice in psychiatric outpatient settings in Sweden was used. A hierarchical linear regression model and a variance component model were used to analyze the data. Regression models were also used to determine how the relation between the GAF and axis I depends on the selection of diagnostic groups in the sample. RESULTS: Seventeen percent of the systematic variance in GAF scores was explained by diagnostic differences as defined on DSM-IV axis I, and 5.1 percent was explained by psychosocial and environmental problems as measured on DSM-IV axis IV. Unexpectedly, the site of the investigation explained another 3.6 percent of the variance. CONCLUSIONS: The GAF can be used as a comprehensive measure of global mental health in routine clinical work for assessment and for outcome management.

Adolescent↗

Computer-simulated phacoemulsification.

OBJECTIVE: To develop a simulator for training in phacoemulsification to be used as a learning device for both beginners and experienced surgeons to shorten the learning curve. DESIGN: Experimental study. METHODS: The system consists of a personal computer, a 3-dimensional visual interface, a phacoemulsification handpiece, and a nucleus manipulator and foot pedals for control of the phacoemulsification procedure and microscope adjustments. The simulation is based on generalized simulation software that can be also used for the development of other medical simulations. MAIN OUTCOME MEASURES: Qualitative statements given in a questionnaire. Medical students and ophthalmic surgeons with varying experience of phacoemulsification were tested. RESULTS: A simulator for training in phacoemulsification has been developed. The surgical procedures can be practiced any number of times, and there is no risk to patients. The efforts of the surgeon can be evaluated objectively. CONCLUSIONS: Studies have shown that the number of complications for an ophthalmic surgeon learning phacoemulsification decreases exponentially, reaching close to the asymptote only after several hundred procedures. Simulator training might shorten the learning period, reduce expensive supervision by an experienced surgeon, and maintain and improve the skills of experienced surgeons.

Computer Simulation↗

[Cataract in children after autologous bone marrow transplantation. A common, but curable complication].

Bone marrow transplantation (BMT) is an established treatment of hematological malignancies in children. With a rapidly increasing number of long-term survivors, more attention is focused on late sequelae to this therapy. Several cataractogenic factors are involved in BMT, such as ionizing irradiation, corticosteroid treatment, and chemotherapeutic agents. Lens opacity is therefore a potential late side-effect of BMT. The incidence and degree of cataract in 29 children who had undergone autologous or syngeneic BMT were recorded. Median follow-up was eight years (4-10 years). 21 children had received total body irradiation prior to BMT; they all developed cataract of the posterior subcapsular type after three years (median). Six children needed surgical repair in the form of intraocular lens implantation after extracapsular cataract extraction.

Antineoplastic Agents↗

Forceps-guided nuclear cleavage cataract extraction.

We introduce a manual nuclear fragmentation technique, forceps-guided nuclear cleavage. A 5.5 to 7.0 mm superior scleral incision is started 1.5 mm posterior to the limbus. Two additional 1.0 mm paracenteses are made at 3 and 9 o'clock in clear cornea close to the limbus. A continuous curvilinear capsulorhexis (CCC) is created; in most cases, 4 to 5 radial relaxing incisions are made in the CCC. The anterior and equatorial cortex and epinucleus are removed with 2-handed irrigation/aspiration via the 2 paracenteses with the nucleus in the capsular bag. The nucleus is prolapsed into the anterior chamber. A nucleus hook is inserted via the 3 o'clock paracentesis and applied to the 6 o'clock nuclear equator to hold the nucleus. A nucleus cleaving forceps is inserted through the upper incision to the 12 o'clock equator of the nucleus and advanced to one-third depth of the nucleus. The forceps is relaxed while the nucleus is cleaved in half.

Aged↗