Biomedical subjects
Publications and source records attributed to Paula Goolkasian.
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In three experiments, we examined the separate cognitive demands of processing and storage in working memory and looked at how effective the coordination was when items for storage varied in format/modality. A sentence verification task involving arithmetic facts was combined with a span task involving two to six items presented in picture, printed word, or spoken word format. The first two experiments were the same, except for the added requirement of articulation of the math sentence in Experiment 2. Experiment 3 varied the length of the span item and compared recall with recognition performance. The results showed that both spoken words and picture produced superior recall and recognition, as compared with printed words, and are consistent with Baddeley and Logie's (1999) and Mayer's (2001) models of working memory. Also, the differences in processing performance across spans varied with the difficulty of the task but showed the strongest support for the resource allocation model (Foos 1995).
A clinical study tested the therapeutic efficacy of Botulinum toxin A (BTXA) when injected into symptomatic neck muscles after one injection session. Patients with chronic neck pain were randomly assigned to receive either a high dose of an active treatment or an injection of the same volume of normal saline. Patients were compared for 4 months using a comprehensive set of outcome measures that included the Neck Pain and Disability Scale (Spine 24 (1999) 1290) and pressure algometry (Arch Phys Med Rehabil 67 (1986) 406; Pain 30 (1987) 115; Clin J Pain 2 (1987) 207). Analyses were consistent in showing significant benefits from the injection session; however, the effects were not specific to the group treated with BTXA. Both treatment and control groups showed a significant decline in pain and disability across time and an increased ability to withstand pressure on trigger points. The heavy incidence of adverse events in the treatment group may partly explain the absence of a treatment effect specific to BTXA. The results show that a single dose treatment without physical therapy is not effective for chronic neck pain.
Reactions to radiant heat stimuli were measured in pregnant women and in a control group of non-pregnant women matched in age. Receiver operating characteristic curve parameters were computed for each of the stages of pregnancy from the 6th month until the postpartum period. When painful stimuli were used, a group by stage of pregnancy interaction was found in the analysis on the response criterion for reporting pain. Pregnant women were found to be significantly more willing to label radiant heat stimuli as painful during the last 2 weeks of pregnancy than during any of the other stages of pregnancy. The control women tested during the same time sequence as the pregnant women showed stable response criteria across the 6 month testing period. There were no group or stage of pregnancy effects evident when the discrimination accuracy measures were analyzed; nor were any effects found with responses to thermal stimuli. The results suggest that the changes in pain reaction associated with pregnancy are based on non-sensory factors that influence the subject's willingness to report pain.
OBJECTIVE: This research established test-retest reliability and construct validity for the Neck Pain and Disability Scale (NPAD). METHODS: Two groups of patients with neck pain completed the NPAD. The first group filled out the scale twice before treatment, whereas the second completed it with a number of other outcome measures once a month for 4 months, for evaluation of treatment with injections. RESULTS: The reliability coefficient (r2 = 0.93) calculated from the data for the first group of patients indicated high test-retest reliability. Construct validity was demonstrated with the second group when the NPAD was compared with a number of other pain measures and found to have a larger treatment effect. The Neck Pain and Disability Scale factor scores also indicated that treatment effects varied across the four factors. CONCLUSIONS: The NPAD is a stable and responsive measure for patients with neck pain. The Neck Pain and Disability Scale factor scores are useful in identifying treatment effects on the specific dimensions involved in the pain experience.