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Biomedical subjects

Paul Janssen

Publications and source records attributed to Paul Janssen.

22 records · Page 2Linked to original sources

Adjusting pairwise nonparametric equivalence hypothesis tests and confidence intervals for period effects in 3 x 3 crossover trials.

In pharmacokinetic and pharmacodynamic 3 x 3 crossover trials, average bioequivalence and noninferiority between treatments need to be only assessed pairwise in most cases. Due to the restricted number of subjects in such trials, normal distribution assumptions cannot be checked and frequently outliers are encountered, so that a nonparametric approach is more adequate. Therefore, to assess average bioequivalence or noninferiority, a new method is proposed to derive period adjusted nonparametric confidence intervals for pairwise treatment differences.

Chemistry, Pharmaceutical↗

[On the effects of psychoanalytic oriented psychotherapy - an inpatient multicenter study]

Whereas the efficacy of inpatient treatment in socalled psychosomatic rehabilitation clinics in Germany has been well researched and documented, studies involving large samples on the efficacy of inpatient treatment in acute hospitals are lacking. A multicentered retrospective study involving clinics for psychotherapy at three separate universities was conducted on a sample of n=495. The patients were treated on an inpatient basis between April 1990 and July 1998 in one of the clinics. The predominant approach to treatment of these clinics was psychodynamic. Other approaches such as behavioral therapy are integrated. In addition to sociodemographic variables clinical data (SCL-90-R, IIP, BSS, ICD-Diagnosis) at admission and discharge were collected. A follow-up study was not conducted. With an average effect size of 0.84 in terms of clinical scales the results demonstrate good efficacy of inpatient treatment. Effect sizes were high on the depression, obsessive-compulsive and anxiety scale of the SCL-90-R, and were low on the phobia subscale. By self report 55% of all patients indicated they had markedly improved, 22% indicated no change and 6% stated they were worse. 17% of all patients were below the chosen cut-off point of the GSI. Patients with a low level of education took benefit as well from the offered therapy. There was no clear relationship between effect size and length of hospital stay. This may be due to the particular setting of a university clinic.

Journal Article↗

[Changes in alexithymia and emotional awareness during psychotherapeutic inpatient treatment].

The aim of the study was to investigate whether alexithymia and emotional awareness could be improved by psychotherapeutic inpatient treatment. The role of alexithymia and emotional awareness in predicting the treatment outcome was investigated. 48 psychosomatically ill patients completed German versions of the Toronto Alexithymia Scale (TAS-20), the Levels of Emotional Awareness Scale (LEAS), the Symptom Check List (SCL-90-R), the Global Assessment Scale of Function (GAF) and the "Beeinträchtigungs-Schwere-Score" (BSS) to assess the severity of patient psychological impairment. Psychotherapeutic inpatient treatment was associated with a decrease in alexithymia as measured by TAS-20. The expected improvement of emotional awareness failed to be statistically significant. This may be due to the smaller retest reliability of the LEAS. High scores in emotional awareness before therapy as measured by LEAS emerged as a predictor of successful psychotherapy with respect to GAF.

Adult↗

Joint modelling of repeated measurements and event time: application to performance traits and survival of lambs bred in sub-humid tropics.

We considered the analysis of a study for Dorper, Red Maasai and crossbred lambs born over a period of 6 years at the Diani Estate, Kenya. The study was designed to compare survival and performance traits of genotypes with differing susceptibilities to helminthiasis. The available data include information on time to death and repeated measurements of body weight, packed cell volume (PCV) and faecal egg count (FEC) of the animals. In the paper, we consider joint modelling of the survival time and the repeated measurements. Such an approach allows to account for the possible association between the survival and repeated measurement processes. The advantages and limitations of the joint modelling are discussed and illustrated using the Diani Estate study data.

Animals↗