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Biomedical subjects

P de Nicola

Publications and source records attributed to P de Nicola.

At least 19 recordsLinked to original sources
PubMed2005

[A case of perforated small bowel adenocarcinoma as first symptom of Crohn's disease].

A case of perforated small bowel adenocarcinoma presenting as first symptom of Crohn's disease is reported in a 53 years old male patient with abdominal pain and alteration of bowel habits. Endoscopic bioptical sampling demonstrated a Crohn's disease in active stage. The patient underwent medical therapy with resolution of the complained symptomatology; 20 days after discharge the patients is rehospitalized for acute abdomen. A narrowing perforated neoplasia in terminal ileum was discovered at laparotomy. Diffuse peritonitis and metastatic peritoneal implantations were also revealed. An ileocolic resection is performed with ileo-transverse colon anastomosis. The patient dies 4 months later for advanced disease.

Abdomen, Acute↗
PubMed1986

Circadian rhythms of heart rate and premature ventricular beats in the aged.

The chronobiological analysis by means of the cosinor method on the dynamic electrocardiographic tracings of 30 subjects aged over 65 years with no clinical or instrumental signs of heart disease revealed a significant circadian rhythm of heart rate with acrophase in the early afternoon. When compared with a group of 30 young adult subjects, the elderly exhibited only a non-significant reduction of the rhythm amplitude. Elderly patients with heart disease exhibited a similar chronobiological pattern of heart rate. Premature ventricular beats (PVBs) were present in all subjects and occurred mostly during the day. A significant circadian rhythm was present only in elderly heart patients with 30-150 PVBs/h. The circadian distribution of PVBs showed significant interindividual differences with nocturnal acrophase in about one third of the patients. The chronobiological analysis can represent the basis for a more appropriate therapeutic approach to the elderly with PVBs.

Adult↗
PubMed1985

Beta-endorphin and cold pressor test in the aged.

In 8 young and 8 elderly subjects mean values of plasma beta-endorphin were nearly equal under basal conditions. In all subjects the cold pressor test provoked a marked increase of beta-endorphin, which was more evident in young subjects. Mean values of the areas of endorphin modifications were the same in both young and elderly subjects. These results may suggest that after a short-term stimulus, such as the cold pressor test, no marked differences in pituitary secretion between young and elderly subjects may be evidenced.

Adult↗
PubMed1984

Circadian rhythms in the aged: a review.

After a review of the fundamental concepts on chronobiology, the importance of circadian rhythms in the aged was examined on the basis of the data obtained in animals and humans, including personal observations on over 40 blood constituents. During ageing there are significant modifications of circadian rhythms, with frequent diminution of amplitude and a shift of acrophase. The biological, clinical and therapeutic implications of these findings are discussed.

Adult↗
PubMed1984

Circadian rhythms of blood components in dementia senilis.

In eleven patients with dementia senilis circadian rhythms of hematocrit, hemoglobin, erythrocytes, leukocytes, serum iron and transferrin were studied by means of the cosinor method. An evident circadian rhythm was observed for all blood components, except leukocytes. There were no significant differences between patients with dementia senilis and healthy aged persons as far as hematocrit, hemoglobin, erythrocytes, and leukocytes are concerned. Acrophase for serum iron and transferrin occurs a little earlier and mesor is lower than in healthy aged persons.

Aged↗
PubMed1983

Circadian rhythm of immunoglobulins in aged persons.

A circadian rhythm with a high statistical probability was detected for IgA, IgG and IgM in a group of 37 aged subjects. These rhythms have a peak (acrophase) in the early afternoon, around 13h00, with variable confidence interval, which may extend between 8h30 and 17h30. The double amplitude of rhythms is approximately 15% of the mean concentration of antibodies during the day (mesor). No statistical difference was observed in mesor, amplitude or acrophase between males and females or in association with age (below or above 75 years) or in mean concentration of immunoglobulins (inside or outside the adult standard reference value at 8h00).

Aged↗
PubMed1983

Urinary tract infections in the aged: improvement with thymostimulin.

30 aged patients, with chronic urinary tract infections, were treated with a thymus extract (thymostimulin, TP-1 Serono), in combination with antibiotic therapy, according to the antibiogram data, or with antibiotic therapy alone. When thymus extracts were added to the treatment, an improvement of the clinical course of the disease was observed and the severity and duration of the subjective symptoms such as strangury, dysuria, and pollakiuria, were reduced. The two groups of patients presented no modifications of the febrile patterns, nor persistence in or recovery from infection after 30 days of treatment, but especially after 90 days, the frequency of reinfections or the persistence of infections were markedly reduced. During treatment with thymostimulin, there was an evident increase in the cellular immunity tests (T-lymphocytes, rosettes, PHA) as compared with the immunodepression found before treatment.

Aged↗
PubMed1982

[Microcirculation in the conjunctiva and the nail bed in the aged. Symptomatic and clinico-pharmacologic aspects].

Study of the microcirculation primarily involves assessment of the capillaroscopic findings. In the clinical field, these are mainly obtained from small vessels of the conjunctiva and nail bed. In more recent years, microcirculation has been accompanied as a subject of examination by haemorheology. The study of blood viscosity and red cell deformability is the most promising from the practical standpoint. In the diagnostic and physiopathological evaluation of capillaroscopic findings, importance is attached to differentiation of arterial and venous vessels, the size, shape and configuration of the small vessels, and above all the presence of intravasal red cell clumps. In examination of the nail bed, particular attention is directed to oddities in the shape of the capillary loops, venous stasis and congestion pictures (in decompensated heart disease, for example, and in cor pulmonale), and alterations in the subpapillary plexuses. Examination of the conjunctiva takes account of the presence of tortuous and serpiginous vessels, with pronounced dilatations, as observed in cardiocirculatory decompensation and chronic bronchopulmonary diseases. In arteriosclerosis, tortuosity and dilatation, even as far as the formation of microaneurysms, may be accompanied by the percent of stiff, thin vessels in networks or webs of various sizes. Clinical pharmacology tests, such as those employing vasoactive drugs (xanthinol nicotinate, buflomedyl, cyticholine) are of interest. They result in a marked increase in calibre, with the appearance of collaterals, regression of red cell aggregates, and improved blood flow.

Age Factors↗
PubMed1981

Serum ferritin and ageing.

The level of serum ferritin of 226 selected subjects, aged 20 to 93, showed an age-related tendency to rise and in every age studied it was higher in males than in females. This finding is considered to be a consequence of the activation of the reticuloendothelial system and of the increase of iron storage with ageing.

Adult↗