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Biomedical subjects

P de Franciscis

Publications and source records attributed to P de Franciscis.

At least 19 recordsLinked to original sources
PubMed1998

Effects of hormone replacement therapy on glucose metabolism.

OBJECTIVE: To evaluate the relationship between hormone replacement therapy and glucose metabolism, and the possible role played by the administration route. DESIGN: Prospective randomized study. MATERIALS AND METHODS: Eighty-four patients in either surgical or spontaneous menopause were randomly allocated into four groups: 15 patients in surgical menopause were treated with estrogens alone administered transdermically (17 beta-estradiol, 50 micrograms/day); 15 patients in surgical menopause were treated with oral conjugated equine estrogens (0.625 mg/day); 18 patients in spontaneous menopause were treated with transdermic estrogens plus oral progestagen (17 beta-estradiol 50 micrograms/day, acetate medroxyprogestogen 10 mg/day for 12 days per month); 16 patients in spontaneous menopause were treated with oral conjugated equine estrogens (0.625 mg/day) plus oral progestagen (10 mg/day for 12 days per month). Twenty patients not given any medication represented the control group. Before starting the trial and after six months of therapy, glucose and insulin levels before and after an oral glucose loading test were evaluated. Data analysis was performed by means of Student's "t"-test, ANOVA was used to compare mean levels between the groups. Significance was set at p < 0.005. RESULTS: Dosages made after 6 months of therapy showed comparable basal glucose levels in all the studied group, while basal insuline levels in patients taking estrogen alone were lower (76.88 +/- 23.66 vs 95.91 +/- 24.57 in group 1, 80 +/- 13.34 vs 96.91 +/- 18.97 in group 2) than pretreatment values. No significant difference in glucose levels was found after glucose load in the four groups. CONCLUSION. Women treated with estrogen alone have a tendency to a lower insulin response, which could indicate a greater insulin sensitivity. This effect seems to be more evident in transdermic administration than with oral administration. The addition of progestagen seems to wane the increase in insulin sensitivity induced by estrogens.

Administration, Cutaneous↗
PubMed1998

Preoperative GnRH analogue in hysteroscopic metroplasty.

OBJECTIVE: To evaluate the effectiveness of Gonadotropin-Releasing Hormone analogue when administered preoperatively in hysteroscopic metroplasty. DESIGN: Prospective, comparative study. PATIENTS AND MAIN OUTCOME MEASURES: Sixty patients undergoing hysteroscopic metroplasty for septate uterus who were randomly allocated to pretreatment with two injections monthly of Gonadotropin-Releasing Hormone analogue or to no pretreatment. To assess the outcome of surgery three parameters were used: operative time (minutes), fluid adsorption (ml) and intraoperative bleeding. RESULTS: No significant differences in the operating time (21.9 vs 22.9 min), fluid adsorption (395 ml, range 200-550 vs 515 ml, range 250-650), intraoperative bleeding and failure rate were found between pretreated patients and controls. CONCLUSIONS: Preoperative treatment with Gonadotropin-Releasing Hormone analogue showed no advantage in hysteroscopic treatment of mullerian defects, but only an improvement, not statistically significant, in term of reduced operative time and fluid adsorption.

Adult↗
PubMed1998

Tubal patency after laparoscopic treatment of ectopic pregnancy.

OBJECTIVE: To evaluate operative course, tubal patency and reproductive performance after laparoscopic treatment of ectopic pregnancy in relation to initial human chorionic gonadotropin (hCG) values and to the kind of operation. DESIGN: Retrospective study. PATIENTS: Fourty-five patients affected by ectopic pregnancies: thirty-two treated with laparoscopic linear salpingotomy subvided into two groups depending on the hCG serum values < 10,000 mUl/ml (twenty patients: group 1) or > 10,000 mUl/ml (twelve patients Group 2), thirteen patients (Group 3) undergoing laparoscopic salpingectomy. Hysterosalpingographic examination was performed two or three months after surgery. MAIN OUTCOME MEASURES: Operative time, major surgical complications, tubal patency and pregnancy rate after surgery. RESULTS: Operative time was significantly (p < 0.05) lower in both group 1 and 3 (22.5 +/- 3.2 and 19.1 +/- 6.3, respectively) than in group 2 (39.4 +/- 5.6). Bilateral patent tubes were observed in eighteen cases of group 1 (90%) and eight cases of group 2 (60%). No statistically significant differences were found between the pregnancy rate of both group 1 (8/18) and 2 (3/8) and of group 3 (3/11). CONCLUSIONS: Reproductive outcome is similar in both conservative and destructive laparoscopic management of ectopic pregnancy: furthermore it shows a trend of improvement, not statistically significant, in conservative treatment.

Chorionic Gonadotropin↗
PubMed1992

Circadian rhythms of hypothalamic norepinephrine and of some circulating substances in individually housed adult rats.

The circadian rhythms of hypothalamic norepinephrine (NE) and of circulating norepinephrine, epinephrine (E), corticosterone, aldosterone, and serotonin (5HT) were determined in group-housed and in individually housed male adult rats, adapted to a 12/12 light/dark cycle. After 5 weeks of individual housing, compared to group-housed animals, hypothalamic NE mesor decreased, while circulating NE, E, and corticosterone mesor increased. The circadian rhythms of aldosterone and 5HT were unaffected by individual housing.

Adrenocorticotropic Hormone↗
PubMed1988

Tricyclic imipramine modification of the circadian rhythms of hypothalamic serotonin, its precursors and acid catabolite in individually housed rats.

Circadian rhythms of serotonin (5HT), its precursors tryptophan (TP) and 5-hydroxy-tryptophan (5HTP) and its acid catabolite 5-hydroxy-indoleacetic acid (5HIAA), were determined in the hypothalamus of control rats and rats which had been treated continuously with subcutaneous imipramine (10 mg/kg/day) for 2 weeks. Rats were individually housed and entrained to LD 12:12. Controls showed the 5HT and TP peaks in the light and dark periods respectively, as reported in the literature, but no inverted correlation (antiphase) between 5HT and 5HIAA rhythms. Imipramine significantly modified circadian rhythm characteristics: the 5HT acrophase was advanced, that of TP and 5HIAA was delayed. Imipramine also significantly increased hypothalamic 5HT and TP concentrations.

5-Hydroxytryptophan↗
PubMed1988

Man in space.

Explore the source record for details and available documents.

Extraterrestrial Environment↗
PubMed1986

No circadian rhythms of serotoninergic, alpha-, beta-adrenergic and imipramine binding sites in rat brain regions.

Bmax values of the specific binding of [3H]-WB 4101, [3H]-dihydroalprenolol, [3H]-spiperone and [3H]-imipramine to various rat brain regions were determined at 4 hr intervals over 24 hr under circadian conditions. No significant circadian rhythm of binding sites number was found for any receptor investigated in cerebral cortex, hypothalamus or brain stem. Some methodological issues are discussed.

Animals↗
PubMed1979

[Thyroid function and lipid metabolism in rats treated with lithium and cholesterol deficient Nath diet].

The administration of drinking-water, added with LiCl (20mg Li+/l) to rats fed on "atherogenic" diet without cholesterol (casein 20% hydrogenated coconut oil 25%, sucrose 49.1%) for 90 days, elicits an expressive diminution of haematic lipids (triglycerides, free fatty acids, total cholesterol) and hepatic cholesterol. The serum dosages of thyroid hormones T3 and T4 show that the Li+ concentration used in the experiment do not inhibit the glandular functions.

Animals↗
PubMed1978

[Modification in lipoproteins and hepatic and fecal cholesterol levels induced by exogenous lithium in rats on an atherogenic diet].

Rats fed atherogenetic diet and drinking-water containing a well known Li+ concentration show, in comparation to atherogenetic rats which do not receive lithium, an expressive reduction of haematic lipids and hepatic cholesterol with a contemporaneous cholesterol increase in stools. Lipoprotidogram examinations prove that exogenous Li+ is able to prevent the haematic lipoproteins alterations produces by atherogenetic nourishment; electrophoretic pattern of these animals is indeed the same of the one obtained for rats fed usual basal diet and drinking-water.

Animals↗
PubMed1975

Preliminary purification and dosages of the erythropoietic factor from ox-spleen.

The administration of ox-spleen homogenate, whether in rats made polycythemic by blood transfusion or in mice polycythemic by hypoxia, elicited a significant stimulatory effect on the rate of erythropoiesis. This activity remained unchanged even if the spleen, before being homogenized, was exhaustively washed with isotonic buffer pH 7.4 up to the total blood elimination.

Animals↗