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Biomedical subjects

P Zeitoun

Publications and source records attributed to P Zeitoun.

At least 73 records · Page 4Linked to original sources
PubMed1980

[The application in cancerology of continuous pump-tube enteric alimentation (author's transl)].

Malnutrition and cachexia are major consequences of neoplastic diseases. When a response to one or more forms of oncologic therapy is expected, simultaneous application of artificial nutrition is often needed. Continuous pump-tube enteric alimentation is an efficient, well tolerated method which is easy to perform in a medical ward. We fed 29 patients with this technique during a mean of 43,6 days and a daily intake of more than 3500 Kcal. We noticed the following observations: -- when out of the impact of any therapy directed against the tumor the 21 patients with advanced cancers demonstrated an ability to gain weight and to achieve a positive nitrogen balance equivalent to that performed by the 8 non tumor-bearing patients; -- radiation therapy, administered to the head, neck and thorax resulted in an increase of energetic expenditure; -- chemotherapy impairs for a few days the benefits of the enteric alimentation. This paper underlines the possibility of nutritional rehabilitation of patients with a cancer cachexia. The metabolic injury produced by chemotherapy and radiation therapy increases the need for an afficient treatment of the malnutrition in cancer.

Body Weight↗
PubMed1980

Separation of epoxy-embedded cell cultures from plastic flasks for electron microscopy.

Monolayers of cells grown in ordinary plastic flasks are fixed and embedded "in situ" into Epon. When polymerized at 40 C for 4 days instead of the usual 60 C, the Epon sheet containing the cells is easily detached from the bottom of the plastic container. The Epon sheet is observed by light microscopy as a histological preparation. Ultrathin sectioning of preselected areas can then be carried out in a horizontal plane.

Animals↗
PubMed1978

Fine structural classification and comparative distribution of endocrine cells in normal human large intestine.

Rectosigmoid- or colonoscopy biopsies were performed at different levels of the large intestine of 16 adult subjects free from major intestinal disease. Tissue specimens were subsequently examined by electron microscopy. Four different endocrine cell types could be distinguished on the basis of the shape and ultrastructural appearance of secretory granules, of their silver affinity, and of their morphometry. Type I cells (enterochromaffin cells, 60.5%) were argentaffin and presented granules with widely different morphologies, which could correspond to several subtypes. The three other cell types were nonargentaffin. Type II (21.3%) contained granules with a diameter distribution peak of 200 to 300 nm. Type III cells, rare (3.2%), were characterized by small and infrequent granules with a diameter distribution peak of 150 to 200 nm. Type IV cells (7.4%) were characterized by large and round granules with a diameter distribution peak of 300 to 400 nm and resembled the "L cell" of the small intestine. The most endocrine cell-rich portion of the colon was the rectum (179 of 618 cells examined). Type I cells represented approximately 73% of the endocrine cell population from the cecum to the descending colon and decreased to 42% in the rectum. Both the absolute number and the percentage of type II cells increased from the cecum (8%) to the rectum (31%). Type IV cells also increased in the rectum both in absolute number and percentage (14%). The absolute number of type III cells was too small to enable significant differences to be observed.

APUD Cells↗