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Biomedical subjects

P Y Ktonas

Publications and source records attributed to P Y Ktonas.

At least 19 recordsLinked to original sources
PubMed2000

Sleep spindle incidence dynamics: a pilot study based on a Markovian analysis.

Results are reported, based on 5 healthy subjects, concerning patterns in the dynamics of the sequential arrangement of spindles in human stage 2 sleep. Specifically, the conditional probability of incidence of successive spindle lengths and successive inter-spindle intervals is investigated. The results show that successive spindle lengths may be statistically independent. However, their distribution (histogram) may be similar for two different stage 2 periods, one in the first third and another in the second third of the night sleep record. In contrast to the finding about spindle lengths, results show that successive inter-spindle intervals may not be statistically independent. Furthermore, the overall dynamics of the sequential arrangement of inter-spindle intervals may be similar for the two sleep periods. These findings are discussed in the context of the "sleep maintenance" role of spindles.

Adult↗
PubMed1999

An automated system for epileptogenic focus localization in the electroencephalogram.

This paper describes an automated system for the detection and localization of foci of epileptiform activity in the EEG. The system detects sharp EEG transients (STs) in the process, but the emphasis is on epileptic focus localization. A combination of techniques involving signal processing, pattern recognition, and the expert rules of an experienced electroencephalographer, involving considerable spatiotemporal context information, is applied to multichannel EEG data. An overall emphasis on minimizing the number of false-positive sharp transient detections drives the system design. Tested on data from 13 subjects with epileptiform activity and 5 controls, all areas of focal epileptiform activity were detected by the system, although not all of the contributing foci were reported separately. Two false-positive foci were detected as well due to nonfocal spike activity and normal spike-like activity not present in the training set. The system detected 95.7% of the epileptiform events constituting the correctly detected foci, with a false detection rate of 11.1%.

Artifacts↗
PubMed1996

Computer-based recognition of EEG patterns.

A critical "mini-overview" is presented of several computer-based techniques proposed for the automated recognition of specific EEG patterns, important in visual EEG analysis. Both phasic and tonic EEG patterns are addressed. The techniques discussed include methods based on power spectrum analysis and on period-amplitude analysis, "mimetic" methods and related implementations in an expert system approach, and methods based on artificial neural networks.

Electroencephalography↗
PubMed1995

Delta (0.5-1.5 Hz) and sigma (11.5-15.5 Hz) EEG power dynamics throughout quiet sleep in infants.

Twenty-eight healthy infants, split into 3 groups according to age (group 1: 2-6 weeks, n = 10; group 2: 7-14 weeks, n = 10; and group 3: 4-12 months, n = 8), were recorded during the whole night. For each infant, the longest quiet sleep (QS) phase occurring between 8 p.m. and midnight was selected for EEG power spectral analysis. The power in the frequency band related to low-frequency delta waves (0.5-1.5 Hz, "delta band") and the power in the frequency band related to sigma spindles (11.5-15.5 Hz, "sigma band") were analyzed. Group 1 infants showed no significant modification of the power in the sigma band in the course of the QS phase; the power in the delta band showed a significant increase between the second and the third 5 min segment and a decrease thereafter. Group 2 infants showed a progressive reduction of the power in the sigma band, whereas the power in the delta band increased during the first 15 min. In group 3 infants, the sigma band power significantly decreased between the third and the fifth 5 min segment without further changes. The power in the delta band, on the contrary, increased progressively for the first 20 min and showed a second progressive increase beyond 35 min. For both group 2 and group 3 infants, it appeared that the change in delta power preceded the change in sigma power. The above results provide quantitative evidence that a well-defined temporal inhomogeneity pattern in the EEG of the QS phase may appear between 7 and 14 weeks of age and continues from the fourth month on.

Age Factors↗
PubMed1991

Estimation of time delay between EEG signals for epileptic focus localization: statistical error considerations.

A theoretical analysis of the variance for the time delay estimate between two EEG signals, obtained via the phase spectrum method, is presented. Explicit theoretical formulae for the variance are obtained and compared via simulations to experimentally derived results for estimate variability. The variance of the time delay estimate is inversely proportional to the frequency range of interest, to the number of data segments utilized for spectral estimation, and to the coherence between the two EEG signals. The simulations indicate that the formulae can be used even with non-gaussian and relatively narrow-band EEG-like data. A minimum-variance estimate for the time delay is also presented.

Computer Simulation↗
PubMed1990

Developmental changes in the clustering pattern of sleep rapid eye movement activity during the first year of life: a Markov-process approach.

Findings are presented in support of the hypothesis that the tendency of sleep rapid eye movement (REM) activity to group into burst structures changes with age during the first year of life in normal infants. Specifically, by assuming a markovian model for the generation of 1 sec long units of REM activity, it is shown that the propensity of those units to develop a sustained clustering pattern may increase during the first 2 months, possibly reaching a plateau at about 4 months. On the other hand, the overall density of REM activity units may continue to increase beyond that point in time.

Age Factors↗
PubMed1989

Context-based automated detection of epileptogenic sharp transients in the EEG: elimination of false positives.

This paper describes a knowledge-based system for the elimination of false positives in the automated detection of epileptogenic sharp transients in the EEG. The system makes comprehensive use of spatial and temporal context information available on 16 channels of EEG, EKG, EMG, and EOG. A knowledge-based implementation is used because of the ease with which it allows the contextual rules to be expressed and refined. The resulting system is shown to be capable of rejecting a wide variety of artifacts commonly found in EEG recordings, artifacts that cause numerous false positive detections in systems making less comprehensive use of context.

Artificial Intelligence↗
PubMed1988

Non-random patterns of REM occurrences during REM sleep in normal human subjects: an automated second-order study using Markovian modeling.

An automated analysis of the patterns in REM occurrences during REM sleep in 6 healthy young adults was performed, with an emphasis on second-order parameters. It was found that the majority of REMs were grouped in bursts with a tendency to return to the burst mode once outside of it. The occurrence pattern of REMs within bursts was found not to be of a purely random (renewal) nature, in distinction to that of isolated REMs. Second-order REM occurrence patterns, quantified via Markovian modeling, were not stationary when REM period segments of less than 8 min duration were considered, and those patterns remained fairly constant from REM period to REM period within the night. First-order parameters and non-Markovian second-order parameters showed a less stable behaviour throughout the night. It is concluded that there may exist 2 aspects to REM generation, a relatively unstable (i.e., variable) phasic aspect, quantified by first-order parameters, and a more stable tonic aspect, quantified by second- and possibly higher-order parameters.

Adult↗
PubMed1983

Automated analysis of abnormal electroencephalograms.

This paper presents a critical review of various attempts at computerized analysis of abnormal electroencephalograms (EEGs). A description of normal and abnormal EEGs from the viewpoint of the clinician is presented at first, along with guidelines used in the visual detection and quantification of EEG abnormalities, followed by a brief review of some important computerized methodologies for clinical EEG analysis. Automated detection and quantification of epileptogenic EEG transients and seizures are reviewed next, and digital computer (software) as well as hardwired systems are presented. Computerized techniques for the quantification of abnormal EEGs in cerebrovascular disorders and coma, metabolic disorders, and for the localization of brain lesions and tumors are presented as well. Future directions and the general problem of man-machine agreement are elaborated upon.

Brain Diseases↗
PubMed1981

Computer-aided quantification of EEG spike and sharp wave characteristics.

This work presents data from detailed, computer-aided analysis of pertinent electrographic characteristics of well-defined EEG spikes and sharp waves. The data show morphological differences between spikes obtained from different subjects, spikes from different electrode montages, as well as between monophasic and biphasic spikes, and between spikes and sharp waves.

Computers↗
PubMed1981

Spectral analysis vs. period-amplitude analysis of narrowband EEG activity: a comparison based on the sleep delta-frequency band.

This paper presents a comparison of spectral analysis with period-amplitude analysis when applied to the quantification of narrowband electroencephalographic (EEG) activity. In particular, it examines their respective usefulness in quantifying on the average the electrographic content within the delta-frequency band of EEG epochs during human stage 4 sleep. It is shown that while the power spectrum efficiently quantifies the overall power trends in the EEG data, period-amplitude analysis seems to offer more resolution than the power spectrum in detecting electrographic details in amplitude and incidence within relatively narrow frequency bands. Examples are given of the sensitivity of spectral analysis ot both wave amplitude and incidence, and of the fact that--due to the inherent averaging process in the power spectrum generation--spectral analysis cannot differentiate between low-amplitude, high-incidence EEG activity and high-amplitude, low-incidence EEG activity, in contradistinction to period-amplitude analysis. It is also shown that although two EEG epochs may exhibit similar power spectrum plots, their corresponding period-amplitude plots may not be similar. It is emphasized that discrepancies may exist when comparing spectral to period-amplitude analysis due to differences in the definition of "frequency" in the two techniques.

Adult↗
PubMed1979

Automated detection of EEG artifacts during sleep: preprocessing for all-night spectral analysis.

This paper describes a simple artifact detection algorithm which can be used when large amounts of EEG data are to be automatically processed via spectral analysis techniques in a general purpose digital computer, and visual inspection of each EEG epoch becomes an impossible task. The technique is based on a chi-square (chi(2)) goodness-of-fit test to a Gaussian distribution (CSQ), and it was applied to EEG epochs each 30 sec long. This test proved to be very sensitive to non-stationarities in the EEG amplitude distribution for a particular epoch, and it produced a large value for the chi(2) coefficient when an artifact was present. EEG epochs that gave rise to chi(2) coefficients of value larger than a heuristically determined minimum were discarded from further analysis. The above technique enabled efficient data reduction and reliable automatic off-line processing of 50 nights of sleep EEG via spectral techniques.

Action Potentials↗
PubMed1978

Automatic REM detection: modifications on an existing system and preliminary normative data.

This paper describes hardware changes and additions to a previously reported sleep rapid eye movement (REM) automatic detection system. Specifically, it describes the design philosophy of a new and optimum analogue bandpass prefilter, new detection criteria based on a detailed study of the waveform distortion due to AC coupling and bandpass prefiltering and the implementation of an artifact detection system for a more accurate detection of seemingly REM-related electro-oculographic (EOG) waveforms. Preliminary normative data on phasic REM patterns from young adults, detected by the described system, are also presented.

Computers, Analog↗