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Biomedical subjects

P Wurnig

Publications and source records attributed to P Wurnig.

At least 37 records · Page 2Linked to original sources
PubMed1986

The significance of tracheal stenosis in esophageal atresia.

The significance of tracheal stenosis in children operated upon for esophageal atresia is described. Stenosis is caused mainly by tracheal compression by the innominate artery leading to tracheal malacia. Following esophageal repair tracheal compression is increased causing life-threatening asphyctic attacks during feeding. After establishment of diagnosis urgent surgery by means of truncopexy is indicated. The incidence of this complication is about 1 in 20 according to our figures and 1 in 40 according to Filler (Filler et al. 1976).

Esophageal Atresia↗
PubMed1986

Circulating committed and pluripotent haemopoietic progenitor cells, in infants.

Circulating CFU-GM, BFU-E and CFU-MIX were assayed in 21 infants aged between 1 day and 44 weeks. Compared to 15 adults, progenitor cells of all types were increased until 10 weeks following birth and approached the respective ranges of adults thereafter. The mean increases of progenitor cells in infants aged between 1 day and 10 weeks were 26-fold for CFU-GM, 7-fold for BFU-E and 5-fold for CFU-MIX. Our results demonstrate that not only committed progenitor cells (CFU-GM, BFU-E), but also early progenitor cells with the capacity for self-renewal (CFU-MIX), are increased in early infancy. These data further support the hypothesis that high levels of blood progenitor cells in very early stages of life reflect the colonization process of developing bone marrow by circulating progenitor cells and demonstrate the terminal phase of this process during the first 10 weeks after birth.

Adult↗
PubMed1985

Morphological findings in peptic esophageal stenosis with Barrett's ulcer in children.

The morphological findings in three resected specimens of Barrett's ulcer in children are discussed. Nearly identical morphologic changes are found in all cases, even in adults. This pathologic condition is understood as the third or fourth stage of reflux esophagitis. Perforation or even malignant degeneration is described in these cases. Therefore mainly all therapeutic aims must be to prevent these stages.

Barrett Esophagus↗
PubMed1984

Peripheral blood mononuclear cells of splenectomized patients are unable to differentiate into immunoglobulin-secreting cells after pokeweed mitogen stimulation.

The function of B cells from the peripheral blood of splenectomized patients has been investigated at the cellular level. The peripheral blood of these patients contained normal numbers of mononuclear cells (MNC) spontaneously secreting IgG and IgM, but an increased amount of IgA-secreting cells. In contrast to MNC isolated from healthy controls, the patients' peripheral blood MNC were unable to differentiate into immunoglobulin-secreting cells in a pokeweed mitogen-driven culture system. Proliferation in response to pokeweed mitogen, however, was significantly higher with patient MNC as compared to control MNC.

Adolescent↗
PubMed1983

Metronidazole plus cefazolin versus cefazolin in gangrenous and perforated appendicitis in childhood--a prospective randomised trial.

59 children with gangrenous (n = 11) or perforated (n = 48) appendicitis underwent a prospective, randomized trial and received cefazolin or cefazolin plus metronidazole. Whereas postoperative abscesses developed in 44% of the controls, they were seen in 7% of the children who had received metronidazole (p less than 0.001). Relaparotomy for intestinal obstruction had to be performed in 11% and 13% of the cases respectively. The germ most frequently isolated from the abscesses was Bacteroides fragilis.

Appendicitis↗
PubMed1981

[Treatment of Wilms' tumor (author's transl)].

Uniform treatment based on the therapeutic approach of the 1st and 2nd US National Wilms' Tumor Study was decided on in March 1976 by paediatricians, surgeons, urologists and radiotherapists in Austria. Wilms' tumour was diagnosed in 34 children between 1 january 1976 an 29 february 1980 (stage I: n = 11, stage II: n = 8, stage III: n = 8, stage IV: n = 7). Parents of two children refused treatments; both children have since died of metastases. Of the remaining 32 children 29 (90.6%) are alive, 10 for more than 4, 15 for more than 3 and 19 for more than 2 years after diagnosis. 21 children are without need of treatment. Three children have died, one due to postoperative complications, one due to haemorrhagic chickenpox, but free of tumour, and one after insufficient treatment. Two of the five children with a recurrence between 2 1/4 to 15 months after diagnosis had been treated inadequately in the initial phase. The tumour free survival rate in 74.2%. Two children with early occurring or recurrent lung metastases have survived for 53 1/2 and 54 months up to now.

Age Factors↗
PubMed1981

[Gastroschisis and omphalocele: factors affecting prognosis (author's transl)].

24 newborns with omphalocele and 23 with gastroschisis were operated upon in the 10-year period from 1971 to 1981. Mortality was 41% in omphaloceles and 61% in gastroschisis. The mortality of all cases dropped from 77% in the first 5-year period to 28% in the second half of the series. While the operative techniques remained unchanged, the better prognosis of the latter group is associated with better parenteral nutrition and fewer relaparotomies.

Abdominal Muscles↗
PubMed1980

[Tuberculous bronchoesophageal fistula in an infant].

A 2 1/2 months-old infant is reported with the rare complication of bronchooesophageal fistula following tuberculosis. The clinical picture and management, which led to a complete cure, are described and discussed. The causation of such fistula formation is discussed.

Bronchial Fistula↗
PubMed1980

[Rare diseases of the thyroid gland in children].

5 cases of children with rare diseases of the thyroid gland are reported. The good prognosis of malignant tumours in childhood is mentioned. The operative management suitable for the different diseases is discussed.

Adenocarcinoma↗
PubMed1980

[Clinical and neurohistological aspects of constipation in newborn and early childhood].

This study is based on a collection of 385 cases of constipation in newborn infants and young children, investigated clinically and by means of histological and neurohistological examination of biopsies taken from the rectal mucosa. Neurohistological techniques proved superior for the differential diagnosis and, hence, of greater value for determining further therapeutic management, both medical and surcival. Four special problems are discussed: Hirschsprung's disease in different neurohistological and clinical findings in these cases, functional ileus of the large intestine in newborn infants, chronic constipation and, lastly, the problems of anal stenosis and anal atresia. The present series of cases serves to illustrate that colostomy, carried out at the right time, can be a life-saving procedure in coping with the grave problem of a potentially lethal enterocolithis in constipation of different aetiology of the newborn or somewhat older infant. Neurohistological investigation is, however, essential for verification of the diagnosis because in Hirschsprung's disease emergency colostomy prevents the development of megacolon.

Adolescent↗
PubMed1975

[Heparin therapy in postoperative consumption coagulopathy in childhood].

On the basis of clinical symptoms and the results of coagulation tests, some changes in the blood coagulation similar to a consumption coagulopathy were found in eight children in the postoperative phase. In addition to the postoperative routine basic therapy a "low-dosage heparin therapy" was started. 3-5 IU of heparin/kg body weight/hour were administered in the form of a continuous intravenous infusion. The results are discussed.

Age Factors↗