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Biomedical subjects

P Woller

Publications and source records attributed to P Woller.

At least 19 recordsLinked to original sources
PubMed1982

[Kidney radionuclide diagnosis in the evaluation of clinical problem cases in pediatrics and nephrology].

An internistically and nephrologically as well as paediatrically well preexamined and selected group of patients in particular cases needs for the judgment of the renal function and capacity a nuclear-medical diagnostics which passes these preexaminations. Renal sequence scintigraphy including the trend scintigraphy and examinations of the renal clearance with side-separated judgment of the renal clearance with side-separated judgment of the function are at our disposal. The indication of these techniques and the value of evidence are demonstrated with the help of problem cases. As problem cases are demonstrated a child with glomerulonephritis, a female patient with renal failure post partum before and after haemodialysis including the observation of the course a female patient with localized inflammatory disease as well as a patient with kidney tumour and cirrhosis of the kidney. It is shown that nuclear-medical techniques recognize relatively discrete, but also severe pathological changes and are necessary within a complex judgment of the function, the quantitative establishment of the functional and compensatory capacity of the kidneys as well as for the planning of therapy and the control of the course.

Acute Kidney Injury↗
PubMed1979

[Fundamental investigations for the deposition of aerosols from radioactive solutions in the upper and lower airways (author's transl)].

By means of 99mtechnetium diphosphonate and a scintillation camera we measured the deposition of aerosols. During normal breathing rhythm and without leading the aerosol by valves the retention in the lower airways was on an average of 5.6%, that is 0.07 ml/min. By installation of suitable valves for in- and expiration and mouth tubes, deep and complete expiration with breath holding the retention of the aerosol increases to 17.3-13.8% (0.22-0.17 ml/min); with normal breathing the deposition was only 9%. In the upper airways we found the following deposition rates: Nose/hypopharynx (inhalation via mask) 2.6%; Mouth and pharynx (after rinsing) 1.6%; Larynx 0.1%. A considerable part remains in the inhalation system; by special variations we were able to reduce this portion of the aerosol. After inhaling electro-aerosols (4 kv) the deposition in the lungs was 5.6%; the more the charge was reduced the more the deposition of the aerosol in the lung increased.

Aerosols↗
PubMed1978

[Deposition of aerosols into the airways (author's transl)].

The rate of powder absorbed in the lung greatly depends on the particle diameter, and amounts to 40--50% for 1 micrometer particles and 15--20% for 5 micrometer particles. Of importance for therapy was the information that single breath will deposit in the lung 15% of a powder aerosol of 2 micrometer diameter. The liquid aerosols as prevalently used in the therapy, were retained in the lung at a rate of 15% of the original amount when using ultrasonic apparatus. If calculated per minute of inhalation time, the amount absorbed by the lung amounted to 0.2 ml and that by the upper respiratory tract to 0.06 ml. Best deposition in the lung was obtained when inhaling in a closed system with valve-controlled aerosol stream, when using a mouthpiece, and when the test person inhaled with low respiratory rate, deep inspirations, short respiratory pause and complete exspiration. Mark inhalation with closed mouth gave only one tenth of the lung deposition reached with the breathing method described. The use of a mask showed good results, however, when the test person was breathing with open mouth. Only 0.07 ml/min were retained with jet nebulizer and mouth respiration. Combination with intermittent pressure respiration showed no convincing results.

Aerosols↗
PubMed1977

[Simultaneous determination of effective renal plasma flow and glomerular filtration rate using a double isotope technic--determination of the filtration fraction].

A method for the simultaneous determination of the effective renal plasma flow and of the glomerular filtration rate with the help of 131J-o-iodohippuric acid and 169Yb-DTPA using a double isotopic technique is described. Apart from this the method serves for the establishment of the filtration fraction. 40 patients with different clinical pictures (glomerulonephritis, pyelonephritis, cystic kidneys, stenosis of the renal artery) were examined. The clearance values established by us were in the areas characteristic for the clinical pictures. Pathological conditions could be established which are not yet characterized by an increase of the fixa of the urine in the serum. By the determination of the filtration fraction differential-diagnostically important insights are afforded. The examination is methodically simply to be performed and is of little stress for the patient. Therefore it seems to be suitable for the routine examination.

Glomerular Filtration Rate↗
PubMed1976

[Determination of the renal clearance in combination with isotope nephrography].

The possibilities of a determination of the renal clearance including the separation of sides with the help of simple nuclear-medical examination and measuring techniques are described. In 50 patients the determination of the effective flow of renal plasma was carried out with 131J-labelled iodohippuric acid. Methodic variants were compared. The examinations of the patient last one hour. They can be carried out in the outpatient department within the isotopic nephrography. In addition to this only several takings of blood samples are necessary. A catheterization of the urinary bladder as it is necessary for the classical determinations of the clearance is no more to be done. The results show that with the help of the methods described valuable quantitative informations about the function of the kidneys are to be got.

Glomerular Filtration Rate↗