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Biomedical subjects

P Wolff

Publications and source records attributed to P Wolff.

At least 37 records · Page 2Linked to original sources
PubMed1991

Mental imagery and dyslexia: a deficit in processing multipart visual objects?

Dyslexic and normal control subjects memorized simple line patterns inside a grid and subsequently judged whether an "X" would have fallen on the pattern had it been present in an empty grid. The patterns were letters and novel shapes. The grids were presented to the left visual field, to the right visual field, or in central vision. Dyslexic subjects had difficulty generating images of multipart patterns, but this deficit was limited to letters. The findings suggest that dyslexics may have selective difficulty integrating visual information stored in long-term memory.

Adolescent↗
PubMed1991

Conversational skills of individuals with fragile-X syndrome: a comparison with autism and Down syndrome.

The conversational skills of 18 individuals with fragile-X syndrome (FXS) were compared with those of two other matched groups with autism and Down syndrome. The FXS group used more eliciting forms in conversation than those with Down syndrome, and also used partial self-repetition more often than the other two groups. The Down syndrome group had more speech dysfluencies than those with autism, but not more than those with FXS. The autistic group used more inappropriate phrases. Qualitative analysis of behavioral phenotype may reveal differences in communicative organization among subgroups whose retardation is based on different genotypes. In addition, analysis of verbal strategies during conversation suggests important differences between individuals with FXS and autism.

Adolescent↗
PubMed1990

[Ethic problems caused by the information of families of organ donors].

Before organ harvesting, previous information of the donor's family is mandatory in France. However information's content and consequences are not specified and may vary widely between hospitals. In some institutions, relatives are only informed of harvesting intent; in others, some teams require family's authorization before harvesting. To make easier and more efficient this information some improvements are suggested.

Brain Death↗
PubMed1988

[Intra-arterial flow phenomena in spin echo procedures of magnetic resonance imaging and in transesophageal 2-dimensional echocardio- graphy].

In 10 pts. with mitral valve lesions dense spontaneous echographic contrast was found within the left atrium by transoesophageal echocardiography. Because of the neurologic symptoms some of the patients also had (transitoric ischemic attacks, embolism) left atrial thrombosis was suspected. The echographic phenomenon of spontaneous left atrial contrast was further examined by magnetic resonance imaging in all 10 pts. Using the spin-echo-mode the multi-echo-imaging showed dense signals in the second echo and no or few left atrial signals in the first echo in 8/10 pts. In 2/10 pts. there were no increased signals in left atrium. The missing presence of the increased signals in the first echo excluded thrombosis of the left atrium and proved blood flow effects.

Adult↗
PubMed1987

[Computerized tomography of the thorax in intensive care patients].

Thoracic CT for patients in intensive care is cumbersome but provides important additional information in the presence of complicated lung changes. Total opacification of a lung field visualised on conventional portable films may be due to infiltration and/or fluid and/or collapse by using the clinical information in conjunction with densitometric measurements. CT may help in the differentiation of pulmonary oedema, particularly in the presence of ARDS and its complications. It is also possible to accurately localise abscesses and empyemas in the presence of extensive consolidation. This makes it possible to drain abscesses or empyemas, or pleural fluid in unusual situations, which has become loculated, or to aspirate a pneumothorax.

Adult↗
PubMed1987

[Ultrasonic diagnosis, computed tomography and lymphography of retroperitoneal lymphomas--re-evaluation of lymphography].

Regarding the present results and the review of literature, we are of the opinion that negative attitude towards lymphography is not justified. In diagnostic procedure, priority is given to sonography and computed tomography because of their non-invasiveness. Lymphography is indispensable in all cases where sonography or computed tomography show negative findings and where the therapy planning depends on evidence or exclusion of retroperitoneal lymphomas. In general the combination of both computed tomography and lymphography is the most sensitive and consequently, the safest method in the diagnosis of retroperitoneal lymphomas.

Evaluation Studies as Topic↗
PubMed1986

Coronary thrombolysis during acute myocardial infarction by intravenous BRL 26921, a new anisoylated plasminogen-streptokinase activator complex.

The safety and fibrinolytic efficacy of a new anisoylated plasminogen-streptokinase activator complex (APSAC) was tested in 50 patients with acute myocardial infarction (AMI) less than 4 hours in duration. APSAC (30 mg) was given intravenously as a bolus injection 151 +/- 47 minutes after clinical symptoms. Coronary angiography was then performed to assess coronary artery patency: 28 patients had an inferior AMI and 22 an anterior AMI. A patent infarct-related artery was found in 32 patients (64%) on first coronary angiography 66 +/- 21 minutes after administration of APSAC. Subsequent reperfusion was observed in 10 patients after 74 +/- 16 minutes (84%). Bleeding complications or hematomas were observed in 18 patients, of whom 3 required blood transfusions. Marked hypofibrinogenemia was observed within 24 hours in most patients. A control coronary angiogram was recorded in 37 patients (74%) after 25 +/- 19 days and showed reocclusion in 5 patients.

Adult↗
PubMed1986

Diffuse nodular hyperplasia and fibrosis of the liver in lead-poisoned mandrills.

Two sibling mandrills with clinical evidence of lead intoxication showed previously unreported hepatic alterations. The younger animal had high lead concentrations in blood, kidneys, and liver and characteristic intranuclear inclusions in renal tubules and hepatocytes. The liver showed diffuse nodular regenerative hyperplasia. The older mandrill had high lead concentrations in blood only and resolving intranuclear inclusions in liver and kidneys. The liver showed prominent portal fibrosis with evidence of resolving diffuse nodular hyperplasia. Occipital horn hydrocephalus was also present.

Animal Diseases↗
PubMed1986

Aortic dissection in a gorilla.

Autopsy findings in a 39-year-old male gorilla included aortic dissection, internal rupture of the aortic arch with axial direction of the tear, external rupture of the ascending aorta, cardiac tamponade, myocardial hypertrophy, cystic and basophilic degeneration of the aortic media, marked obesity, severe degenerative joint disease, focal glomerulonephritis, and widespread hemosiderosis.

Aortic Dissection↗
PubMed1985

Complexes of viroids with histones and other proteins.

Complexes of potato spindle tuber viroid (PSTV) with nuclear proteins have been studied by in vitro reconstitution of the complexes and by isolation and characterization of in vivo complexes under non-dissociating conditions. For in vitro reconstitution, nuclear proteins were separated by SDS-gel-electrophoresis, renatured and blotted onto nitrocellulose filters, and incubated with viroid. The viroid-protein complexes were crosslinked covalently, and the viroid containing protein bands were detected by northern hybridization with a radioactive cDNA probe. The histones, a 41,000 dalton protein and to a small extent a 31,000 dalton protein were found in complexes with viroids. Raising the strength to 0.4 M NaCl destroys the complexes with the 41,000 dalton proteins but not those with the histones. From nucleoli, which are known to obtain the majority of viroids under non-dissociating conditions (Schumacher et al., (1983) EMBO J. 2, 1549-1555), a nucleosomal fraction was prepared. Viroids were found predominantly in this nucleosomal fraction. They are bound in a complex of 12-15 svedberg units.

Cell Nucleus↗
PubMed1985

[Quantitative cardiac computed tomography].

The scope and limitations of quantitative cardiac CT have been evaluated in a series of experimental and clinical studies. The left ventricular muscle mass was estimated by computed tomography in 19 dogs (using volumetric methods, measurements in two axes and planes and reference volume). There was good correlation with anatomical findings. The end-diastolic volume of the left ventricle was estimated in 22 patients with cardiomyopathies; using angiography as a reference, CT led to systematic under-estimation. It is also shown that ECG-triggered magnetic resonance tomography results in improved visualisation and may be expected to improve measurements of cardiac morphology.

Animals↗
PubMed1985

[Computed tomography, magnetic resonance tomography and echocardiography in hypertrophic cardiomyopathy].

The value of echo-cardiography, CT and magnetic resonance tomography was evaluated in 10 patients with hypertrophic cardiomyopathy. Echocardiography made the diagnosis in most cases. The diagnostic criteria depended on functional and morphological changes. CT and magnetic resonance can show thickening in the myocardium, either symmetrical or asymmetrical. Magnetic resonance tomography provides excellent demonstration of the myocardium and accurate delineation of the degree of hypertrophy. It is well suited for measuring cardiac wall thickness.

Adolescent↗