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Biomedical subjects

P Werner

Publications and source records attributed to P Werner.

At least 217 records · Page 12Linked to original sources
PubMed1975

[Model for the continuous determination of cell metabolism].

Using the isolated heart of guinea pigs according to the method of Langendorff a new model to study the metabolism of the myocardium is described. In one modification the heart is perfused by continuous flow of Ringer-Locke-solution, and the effluent is discarded. In the other modification the effluent is used for recirculation after saturation with oxygen. The advantage of this method is the possibility to measure oxygen consumption and production of acid metabolites by using pH-electrodes in the perfusion medium before and behind the heart. For measurement, the blood micro system and the acid-base analyzer is used. Many drugs and several unknown compounds have been examined for their influence on heart metabolism and could be classified as either stimulatory, inhibitory or ineffective. It is possible to study dose-response curves of these compounds to compare various compounds and to examine the cumulative or duration effects of combinations. The site of action of a compound and thus the mode of action can be examined as was demonstrated for alpha- and beta-blockers. Perfusion of the heart with glucose-free solution permits measurement of the effect of various energy sources for intensity and duration of effect. The well-known capacity of the heart to use lipids as an energy source could be demonstrated. When a pharmacologically active compound is added to the perfusion medium, glucose consumption, production of lactic acid and of other metabolites can be determined. The results obtained in the isolated heart were confirmed by corresponding tests in the intact animal. The model is highly sensitive to several classes of drugs. In some instances amounts of less than 1 mug can be determined.

Animals↗
PubMed1975

[A contribution to the information and instruction of patients in periodontological practice].

Starting from the necessity of expanding the periodontal care of the population, the author points to the special importance of the patient's education, information and instruction in the periodontal practice and to the employment of dental nurses specialized in dental and oral hygiene. The author's approach which is based on an audiovisual method is explained; its advantages and disadvantages are discussed.

Audiovisual Aids↗
PubMedDate not supplied

Withdrawal of haloperidol, thioridazine, and lorazepam in the nursing home: a controlled, double-blind study.

BACKGROUND: Ongoing regimens of haloperidol, thioridazine, and lorazepam are commonly administered to manage behavior problems in nursing home residents. Nevertheless, there is controversy over whether periodic drug withdrawal should be attempted when those medications are prescribed. This study addressed that issue by examining the effects of discontinuing treatment with haloperidol, thioridazine, and lorazepam among residents of a large suburban nursing home. METHODS: In a double-blind, crossover study, half of 58 nursing home residents (43 women and 15 men with a mean age of 86 years) continued to take the psychotropic medication they had been prescribed, whereas the other half were tapered to placebo. After 6 weeks of taking placebo or original drug, patients were tapered to the reverse schedule and remained on it for 6 weeks. Assessments included informant ratings by the nursing staff who completed the Brief Psychiatric Rating Scale and the Cohen-Mansfield Agitation Inventory. RESULTS: Analyses comparing residents taking placebo to those taking medication after completion of the first phase showed no impact of drug therapy discontinuation on their behavior. Similarly, using the crossover design to compare residents' behaviors while taking placebo vs. taking drugs, withdrawal of medication had no impact on Cohen-Mansfield Agitation Inventory or Brief Psychiatric Rating Scale scores. CONCLUSIONS: Results of this work suggest that longterm use of haloperidol, thioridazine, and lorazepam in nursing homes to manage agitation should be closely monitored for their efficacy. Furthermore, routine attempts at drug withdrawal should be considered for most residents taking psychotropic medication.

Affect↗