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Biomedical subjects

P Weisweiler

Publications and source records attributed to P Weisweiler.

71 records · Page 4Linked to original sources
PubMed1976

[Effect of clofibrate on glucose tolerance and insulin secretion in patients with endogenous hypertriglyceridemia (author's transl)].

In 22 patients with endogenous hypertriglyceridemia, oral and intravenous glucose tolerance showed significant improvement under clofibrate treatment which was in no way correlated to the fall in triglycerides. Basal and stimulated insulin, cholesterol and fasting blood sugar did not change, body weight remained constant and was not correlated to the degree of hypertriglyceridemia. On the other hand a positive correlation between body weight and insulin concentrations was found. Improvement of glucose tolerance independently of body weight and insulin may be due to a direct effect of clofibrate on glucose metabolism without any correlation to its triglyceride-lowering.

Administration, Oral↗
PubMed1976

[Treatment of primary hyperlipoproteinemias type IV with different biguanides (author's transl)].

In 12 patients with primary type IV hyperlipoproteinemia the lipid lowering effect of constant doses of the biguanides metformin, phenformin and buformin was compared. After a 2 months dietary period bodyweight and initial triglyceride and cholesterol plasma concentrations were stabilized. The three biguanides were given for two months each, and this 6 months drug period was followed by another dietary period. While, 0.15 g phenformin and 2.55 g metformin reduced triglycerides by about 50% the reduction by 0.30 g buformin was only half. This was due to 4 nonresponders with initial triglycerides of more than 700 mg/100 ml. In contrast the triglyceride lowering effect of the other two biguanides was positively correlated to the pretreatment triglycerides. The cholesterol lowering effect of biguanide treatment was far less pronounced. There were no significant alterations of body weight and no influence on basal insulin and glucose concentrations. In conclusion, all three biguanides tested in a dosis of 3 tablets each are effective in lowering triglycerides although differing in efficiency and depending from the degree of typ IV hyperlipoproteinemia.

Biguanides↗
PubMed1975

[Glucose tolerance, insulin and lipids after one week's administration of fenfluramine to overweight patients (author's transl)].

The effect of oral administration of the amphetamine derivative, fenfluramine for one week was investigated in comparison to a placebo for the same period in 28 overweight patients, 57% of whom showed a reduced glucose tolerance. In addition to glucose and insulin, the lipid fractions were also measured. In the series with pathological glucose tolerance in which the body weight remained unchanged, fenfluramine produced a lowering of the basal levels of blood sugar and insulin. After oral loading with glucose the total rise in glucose and the rise in insulin in the late phase were diminished. Free fatty acids, free glycerol, triglycerides and cholesterol were not affected.

Adult↗
PubMed1975

Biological action of the lipotrophic peptides A and B from pig pituitary glands.

In vitro lipolysis was stimulated by porcine pituitary peptides A and B in the rabbit, rat, mouse, and guinea pig. The minimal effective doses were calculated from log dose response curves for free fatty acids and free glycerol liberation. The rabbit was most sensitive responding to 0.008 mug/ml (1.4 pM/ml) peptide A and 0.06 mug/ml (5.3 pM/ml) peptide B respectively. Minipig adipose tissue showed no reaction up to a peptide concentration of 100 mug/ml. After intravenous injection of either peptide at the concentration of 50 mug/kg, FFA and free glycerol increased rapidly in the rabbit with maximal concentrations at 30 min, returning to near normal concentrations after 240 min. Blood glucose concentrations increased continuously in spite of hyperinsulinaemia with a peak concentration at 60 min and complete normalisation after 2 h. Hypertriglyceridaemia and hypocalcaemia were observed in both lipotrophin and control groups. Furthermore, the saline injected rabbits also displayed a slight increase of glucose, FFA, and free glycerol plasma concentrations towards the end of the experiments, suggesting stress stimulated lipolysis. The insulinotrophic effect of both peptides was verified by the fact that injection of lipid emulsion plus heparin led to a comparable increase in FFA and glucose, but to no change in insulin concentrations.

Adipose Tissue↗