A successful device tracking program.
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Consumer Product Safety↗
Biomedical subjects
P Weed
Publications and source records attributed to P Weed.
Nb rat prostate adenocarcinoma model androgen-sensitive tumor: metastasis control.
In this preliminary report, evaluation of nontraditional agents has been used to evaluate control of metastasis. This androgen-sensitive rate prostatic adenocarcinoma has been subject to the treatments of heparin, indocin, and castration, as well as combinations of castration, heparin, indocin, and cyclophosphamide. Tumor volume, metastasis, and determination of regression of primary tumor have been evaluated. Heparin and indocin both reduced metastasis without affecting tumor volume in this study. The combination of castration and cyclophosphamide was most effective in reducing tumor volume when compared to the other groups.
Adenocarcinoma↗
Cultural comparisons of mothers with large and small families.
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Adult↗
The evaluation of heparin in control of metastasis of Nb rat androgen-insensitive prostate carcinoma.
The Nb rat prostatic adenocarcinoma model has served as an animal model for testing various chemotherapeutic agents. This model has two tumor types: androgen-sensitive and androgen-insensitive. Herein, the androgen-insensitive tumor A.I.-II was evaluated in 52 animals, with heparin, heparan, 5-Fu, and cis-platinum for their effects on incidence of metastatic disease. Multiple experiments were previously carried out utilizing this tumor, which consistently has had an incidence of metastatic disease in 40-50% of the animals so implanted. Heparin at both doses and heparan significantly reduced metastasis in this study; however, they were not significant in reducing final tumor volumes as compared to the controls. 5-Fluorouracil at the dose evaluated neither significantly altered tumor volume nor altered metastatic disease. On the other hand, cis-platinum was significantly effective in lowering both metastatic disease and tumor volume (p less than 0.05).
Adenocarcinoma↗