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Biomedical subjects

P Wang

Publications and source records attributed to P Wang.

At least 109 records · Page 6Linked to original sources

Rovibrational-state-selected pulsed field ionization-photoelectron study of methyl iodide using two-color infrared-vacuum ultraviolet lasers.

The preparation of methyl iodide (CH(3)I) in selected rovibrational states [nu(7)=1 (C-H stretch); J] by infrared (IR) excitation prior to vacuum ultraviolet (VUV) photoionization has greatly simplified the observed pulsed field ionization-photoelectron (PFI-PE) spectra, allowing the direct determination of the rotational constants B(+)(C(+))=0.254+/-0.003 cm(-1) for CH(3)I(+)(X (2)E(3/2);nu(7) (+)) and the ionization energy (76 896.9+/-0.2 cm(-1)) for CH(3)I(+)(X (2)E(3/2);nu(7) (+)=1,J(+)=3/2)<--CH(3)I(X (1)A(1);nu(7)=1,J=0). The IR-VUV-PFI-PE and IR-VUV-photoion measurements also provide relative state-to-state (nu(7) (+)=1, J(+)<--nu(7)=1, J) cross sections for the photoionization process.

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Search for B+/--->[K(-/+)pi(+/-)](D)K+/- and upper limit on the b-->u amplitude in B+/--->DK+/-.

We search for B+/--->[K(-/+)pi(+/-)](D)K+/- decays, where [K(-/+)pi(+/-)](D) indicates that the K-/+pi(+/-) pair originates from the decay of a D0 or D (0). Results are based on 120x10(6) Upsilon(4S)-->BB decays collected with the BABAR detector at SLAC. We set an upper limit on the ratio R(Kpi) identical with[Gamma(B+-->[K(-)pi(+)](D)K+)+Gamma(B--->[K(+)pi(-)](D)K-)][Gamma(B+-->[K(+)pi(-)](D) / K+)+Gamma(B--->[K(-)pi(+)](D)K-)]<0.026 (90% C.L.). This constrains the amplitude ratio r(B) identical with|A(B--->D 0K-)/A(B--->D0K-)|<0.22 (90% C.L.), consistent with expectations. The small value of r(B) favored by our analysis suggests that the determination of the Cabibbo-Kobayashi-Maskawa phase gamma from B-->DK will be difficult.

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Measurements of CP-violating asymmetries in B0-->K(0)(s)pi(0) decays.

We present a measurement of the time-dependent CP-violating (CPV) asymmetries in B0-->K(0)(S)pi(0) decays based on 124x10(6) Upsilon(4S)-->BB decays collected with the BABAR detector at the PEP-II asymmetric-energy B factory at SLAC. In a sample containing 122+/-16 signal decays, we obtain the magnitudes of the direct CPV asymmetry CK(0)(S)(pi(0))=0.40(+0.27)(-0.28)+/-0.09 and of the CPV asymmetry in the interference between mixing and decay SK(0)(S)(pi(0))=0.48(+0.38)(-0.47)+/-0.06 where the first error is statistical and the second systematic.

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Direct CP violating asymmetry in B0-->K+pi- decays.

We present a measurement of the direct CP violating asymmetry in the decay B0-->K+pi(-) using a data sample of 227x10(6) Upsilon(4S)-->BB decays collected with the BABAR detector at the PEP-II asymmetric-energy e(+)e(-) collider at SLAC. We observe a total signal yield of nK-(pi(+))+nK+(pi(-))=1606+/-51 decays and measure the asymmetry (nK-(pi(+))-nK+(pi(-)))/(nK-(pi(+))+nK+(pi(-)))=-0.133+/-0.030(stat)+/-0.009(syst). The probability of observing such an asymmetry in the absence of direct CP violation is 1.3x10(-5), corresponding to 4.2 standard deviations.

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Search for B0 decays to invisible final states and to nunugamma.

We establish upper limits on branching fractions for B0 decays to final states where the decay products are purely invisible (i.e., no observable final state particles) and for B0 decays to nunugamma. Within the standard model, these decays have branching fractions that are below current experimental sensitivity, but various models of physics beyond the standard model predict significant contributions from these channels. Using 88.5 x 10(6) BB pairs collected at the Upsilon(4S) resonance by the BABAR experiment at the PEP-II e(+)e- storage ring at the Stanford Linear Accelerator Center, we establish upper limits at the 90% confidence level of 22 x 10(-5) for the branching fraction of B0-->invisible and 4.7 x 10(-5) for the branching fraction of B0-->nunugamma.

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Measurement of the B-->Xsl+l- branching fraction with a sum over exclusive modes.

We measure the branching fraction for the flavor-changing neutral-current process B-->X(s)l(+)l(-) with a sample of 89x10(6) Upsilon(4S)-->BBmacr; events recorded with the BABAR detector at the PEP-II e(+)e(-) storage ring. The final state is reconstructed from e(+)e(-) or micro(+)micro(-) pairs and a hadronic system X(s) consisting of one K+/- or K(0)(S) and up to two pions, with at most one pi(0). We observe a signal of 40+/-10(stat)+/-2(syst) events and extract the inclusive branching fraction B(B-->X(s)l(+)l(-))=(5.6+/-1.5(stat)+/-0.6(exp syst)+/-1.1(model syst))x10(-6) for ml(+)(l(-))>0.2 GeV/c(2).

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Bound on the ratio of decay amplitudes for -B0-->J/psiK*0 and B0-->J/psiK*0.

We have measured the time-dependent decay rate for the process B-->J/psiK(*0) (892) in a sample of about 88x10(6) Upsilon(4S)-->B(-)B decays collected with the BABAR detector at the PEP-II asymmetric-energy B factory at SLAC. In this sample we study flavor-tagged events in which one neutral B meson is reconstructed in the J/psiK(*0) or J/psi(-)K(*0) final state. We measure the coefficients of the cosine and sine terms in the time-dependent asymmetries for J/psiK(*0) and J/psi(-)K(*0), find them to be consistent with the standard model expectations, and set upper limits at 90% confidence level (C.L.) on the decay amplitude ratios |A((-)B(0)-->J/psiK(*0))|/|A(B0-->J/psiK(*0))|<0.26 and |A(B0-->J/psi(-)K(*0))|/|A((-)B(0)-->J/psi(-)K(*0))|<0.32. For a single ratio of wrong-flavor to favored amplitudes for B0 and (-)B(0) combined, we obtain an upper limit of 0.25 at 90% C.L.

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Measurement of the time-dependent CP asymmetry in the B0-->phiK0 decay.

We present a measurement of the time-dependent CP asymmetry for the neutral B-meson decay B0-->phiK0. We use a sample of approximately 114 x 10(6) B-meson pairs taken at the Upsilon(4S) resonance with the BABAR detector at the PEP-II B-meson factory at SLAC. We reconstruct the CP eigenstates phiK0S and phiK0L, where phi-->K+K-, K0S-->pi+pi-, and K0L is observed via its hadronic interactions. The other B meson in the event is tagged as either a B0 or Bbar0 from its decay products. The values of the CP-violation parameters are SphiK=0.47+/-0.34(stat)+0.08-0.06(syst) and CphiK=0.01+/-0.33(stat)+/-0.10(syst).

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Study of high momentum eta' production in B --> eta'Xs.

We measure the branching fraction for the charmless semi-inclusive process B --> eta'Xs, where the eta' meson has a momentum in the range 2.0 to 2.7 GeV/c in the upsilon4S center-of-mass frame and Xs represents a system comprising a kaon and zero to four pions. We find B(B --> eta'Xs) = [3.9 +/- 0.8(stat) +/- 0.5(syst) +/- 0.8(model)] x 10(-4). We also obtain the Xs mass spectrum and find that it fits models predicting high masses.

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Measurement of branching fractions and charge asymmetries in B+/--->rho+/-pi0 and B+/--->rho0pi+/- decays, and search for B0-->rho0pi0.

We present measurements of branching fractions and charge asymmetries in B-meson decays to rho(+)pi(0), rho(0)pi(+), and rho(0)pi(0). The data sample comprises 89x10(6) Upsilon(4S)-->BBmacr; decays collected with the BABAR detector at the PEP-II asymmetric-energy B Factory at SLAC. We find the charge-averaged branching fractions B(B+-->rho(+)pi(0))=[10.9+/-1.9(stat)+/-1.9(syst)]x10(-6) and B(B+-->rho(0)pi(+))=(9.5+/-1.1+/-0.9)x10(-6), and we set a 90% confidence-level upper limit B(B0-->rho(0)pi(0))<2.9x10(-6). We measure the charge asymmetries ACP(pi(0))(rho(+))=0.24+/-0.16+/-0.06 and ACP(pi(+))(rho(0))=-0.19+/-0.11+/-0.02.

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Observation of the decay B-->J/psietaK and search for X(3872)-->J/psieta.

We report the observation of the B meson decay B+/- -->J/psietaK+/- and evidence for the decay B0-->J/psietaK0S, using 90 x 10(6) BB; events collected at the Upsilon(4S) resonance with the BABAR detector at the SLAC PEP-II e+e- asymmetric-energy storage ring. We obtain branching fractions of B(B+/- -->J/psietaK+/-) = [10.8 +/- 2.3(stat) +/- 2.4(syst)] x 10(-5) and B(B0-->J/psietaK0S) = [8.4 +/- 2.6(stat) +/- 2.7(syst)] x 10(-5). We search for the new narrow mass state, the X(3872), recently reported by the Belle Collaboration, in the decay B+/- -->X(3872)K+/-,X(3872)-->J/psieta and determine an upper limit of B[B +/- -->X(3872)K+/- -->J/psietaK+/-] < 7.7 x 10(-6) at 90% confidence level.

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Measurement of the direct CP asymmetry in b-->s gamma Decays.

We describe a measurement of the direct CP asymmetry between inclusive b-->s gamma and b-->s gamma decays. This asymmetry is expected to be less than 0.01 in the standard model, but could be enhanced up to about 0.10 by new physics contributions. We use a sample of 89 x 10(6) BB pairs recorded with the BABAR detector at SLAC PEP-II, from which we reconstruct a set of 12 exclusive b-->s gamma final states containing one charged or neutral kaon and one to three pions. We measure an asymmetry of A(CP)(b-->s gamma)=0.025+/-0.050(stat)+/-0.015(syst), corresponding to an allowed range of -0.06 s gamma)<+0.11 at 90% confidence level.

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Proliferation of cultured human gingival fibroblasts caused by isradipine, a dihydropyridine-derivative calcium antagonist.

As it was reported earlier that isradipine, a Ca superset 2+ antagonist of dihydropyridine derivative class, caused regression of nifedipine-induced hyperplasia of human gingiva, experiments were performed to examine whether or not isradipine would solely inhibit the proliferation of cultured gingival fibroblasts. Normal human gingival fibroblast Gin-1 cells were used to test the impact of this medication. Fibroblast proliferation in the presence of isradipine (10 microM) was examined by using the reagent water-soluble tetrazolium-1 (WST-1). The level of basic fibroblast growth factor (bFGF) in the cell-free supernatant of each well was determined by using an enzyme-linked immunosorvent assay (ELISA) kit. The production of type I collagen was assayed by ELISA. Isradipine significantly enhanced the cell proliferation from the second day of the culture period. Also, isradipine raised the level of bFGF in the culture medium. The same concentration, also significantly enhanced the production of type I collagen. In conclusion, we were able to prove that isradipine causes the proliferation of cultured gingival fibroblasts as well as other dihydropyridine-derivative Ca superset 2+ antagonists do. In order to prevent the gingival overgrowth, it is advisable to be very careful in the use of isradipine as a therapy for hypertension and other indications.

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Measurement of time-dependent CP asymmetries in B0-->D(*)+/-pi-/+ decays and constraints on sin(2beta+gamma).

We present a measurement of CP-violating asymmetries in fully reconstructed B0-->D(*)+/-pi-/+ decays in approximately 88 x 10(6) upsilon(4S)-->BBmacr; decays collected with the BABAR detector at the PEP-II asymmetric-energy B factory at SLAC. From a time-dependent maximum-likelihood fit we obtain the following for the CP-violating parameters: a=-0.022+/-0.038 (stat)+/-0.020 (syst), a*=-0.068+/-0.038 (stat)+/-0.020 (syst), c(lep)=+0.025+/-0.068 (stat)+/-0.033 (syst), and c*(lep)=+0.031+/-0.070 (stat)+/-0.033 (syst). Using other measurements and theoretical assumptions we interpret the results in terms of the angles of the Cabibbo-Kobayashi-Maskawa unitarity triangle, and find |sin((2beta+gamma)|>0.69 at 68% confidence level. We exclude the hypothesis of no CP violation [sin(2beta+gamma)=0] at 83% confidence level.

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Measurement of time-dependent CP asymmetries and constraints on sin(2beta+gamma) with partial reconstruction of B0-->D*-/+pi+/- decays.

We present a measurement of time-dependent CP-violating asymmetries in decays of neutral B mesons to the final states D(*-/+)pi(+/-), using approximately 82x10(6) BBmacr; events recorded by the BABAR experiment at the PEP-II e(+)e(-) storage ring. Events containing these decays are selected with a partial reconstruction technique, in which only the high-momentum pi(+/-) from the B decay and the low-momentum pi(-/+) from the D(*-/+) decay are used. We measure the amplitude of the asymmetry to be -0.063+/-0.024(stat)+/-0.014(syst) and compute bounds on |sin((2beta+gamma)|.

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Study of B+/ --> J/psi pi+/- and B+/ -->J/psi K+/- decays: measurement of the ratio of branching fractions and search for direct CP violation.

We study B+/ --> J/psi pi(+/-) and B+/ --> J/psi K+/- decays in a sample of about 89 x 10(6) BB pairs collected with the BABAR detector at the PEP-II asymmetric B factory at SLAC. We observe a signal of 244+/-20 B+/ --> J/psi pi(+/-) events and determine the ratio B(B+/ --> J/psi pi(+/-))/B(B+/ --> J/psi K+/-) to be [5.37+/-0.45(stat)+/-0.11(syst)]%. The charge asymmetries for the B+/ --> J/psi pi(+/-) and B+/ --> J/psi K+/- decays are determined to be A(pi)=0.123+/-0.085(stat)+/-0.004(syst) and A(K)=0.030+/-0.015(stat)+/-0.006(syst), respectively.

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Search for the rare leptonic decay B+-->mu(+)nu(mu).

We have performed a search for the rare leptonic decay B+-->mu(+)nu(mu) with data collected at the Upsilon(4S) resonance by the BABAR experiment at the PEP-II storage ring. In a sample of 88.4 x 10(6) BB pairs, we find no significant evidence for a signal and set an upper limit on the branching fraction B(B+-->my(+)nu(my))< 6.6 x 10(-6) at the 90% confidence level.

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Single-photon vacuum-ultraviolet laser-pulsed-field ionization-photoelectron studies of trans- and cis-1-bromopropenes.

The vacuum-ultraviolet (VUV) pulsed-field ionization-photoelectron (VUV-PFI-PE) spectra of trans-1-bromopropene (trans-CH(3)CH[Double Bond]CHBr) and cis-1-bromopropene (cis-CH(3)CH[Double Bond]CHBr) have been measured in the energy region of 74 720-76 840 cm(-1). The simulation of fine structures observed in the origin VUV-PFI-PE vibrational bands of these molecules has provided the ionization energies (IEs) of trans-1-bromopropene and cis-1-bromopropene to be 74 779.3+/-2.0 cm(-1) (9.2715+/-0.0002 eV) and 75 140.2+/-2.0 cm(-1) (9.3162+/-0.0002 eV), respectively. The vibrational bands resolved in these VUV-PFI-PE spectra at energies 0-1700 cm(-1) above the IEs of trans-1-bromopropene and cis-1-bromopropene have been assigned based on theoretical vibrational frequencies and calculated Franck-Condon factors for the ionization transitions.

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