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Biomedical subjects

P W Scott

Publications and source records attributed to P W Scott.

16 recordsLinked to original sources
PubMed1998

Bronchial asthma deaths in Jamaica.

Many countries have reported an increase in the death rate from bronchial asthma. Evaluation of the situation in Jamaica was undertaken to see if the trend is similar to that reported from elsewhere by analysing deaths for the period 1980 to 1989. There was an increase in the death rate during the period studied, most marked in females in rural areas. Most of the deaths occurred outside medical facilities. The reasons for these trends are not clear.

Asthma↗
PubMed1985

A novel metabolite of tinidazole involving nitro-group migration.

After oral doses to dogs of 14C-tinidazole, a 5-nitroimidazolyl antiprotozoal compound, a major and previously unidentified radioactive metabolite was isolated from urine and shown by FAB mass spectrometry and n.m.r. spectroscopy to be ring-hydroxylated. The exact identity of this metabolite was established by X-ray diffraction analysis as ethyl 2-(5-hydroxy-2-methyl-4-nitro-1-imidazolyl)ethyl sulphone. The apparent migration of the nitro group from the 5 position in the parent drug to the 4 position in the metabolite is a novel metabolic route.

Animals↗