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Biomedical subjects

P W Rand

Publications and source records attributed to P W Rand.

At least 37 records · Page 2Linked to original sources
PubMed1975

A pH-dependent macroglobulin gel.

Plasma from a patient with Waldenstrom's macroglobulinemia was observed to gel upon exposure to room air, yet to remain in solution indefinitely at 4 degrees C if sealed. Three studies were carried out which showed this change not to be due primarily to decreases in carbon dioxide tension or temperature, but to variations in the concentration of hydrogen ions within or just above physiologic levels. In purified material (IgM) a marked increase in viscosity occurred between pH 7.5 and 8.0, followed by precipitation between pH 8.0 and 9.7, and by reversible dissolution between pH 9.7 and 10.0. The analytical and clinical consequences of these solubility changes are discussed.

Aged↗
PubMed1975

Effects of shifts in hemoglobin-oxygen affinity during hypoxia.

To investigate the possibility that the influence of hemoglobin-oxygen affinity on tissue oxygenation may be reversed in severe hypoxia, 16 anesthetized rabbits with chronically-implanted tissue oxygen electrodes were ventilated with 12% oxygen and subjected to 100 ml exchange transfusions with high, low, or normal affinity rabbit blood. Despite the widely divergent in vivo P50 values produced, significant differences in tissue oxygen levels were not observed among the three groups following exchange transfusions. During subsequent normoxia, more complete recovery of tissue oxygen was apparent in the low affinity group. This study emphasizes the need for further definition of the influence of hemoglobin-oxygen affinity on the functions of individual organs.

Animals↗