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Biomedical subjects

P W Gelderman

Publications and source records attributed to P W Gelderman.

6 recordsLinked to original sources

The operative stabilization and grafting of thoracic and lumbar spinal fractures.

In this paper several concepts of surgical treatment of thoracic and lumbar fractures are reviewed. Most classifications of these fractures are primarily radiologic, but pathomechanical aspects are very important as these guide the insight into and the rationale of the different modes of treatment. The segment of movement can be considered biomechanically as a three-dimensional system, built up from two rings, linked together at five functional points of support. Our principal mode of surgical therapy after closed reduction by halo-femoral traction is anterolateral decompression, stabilization and grafting to induce fusion. In suitable cases, a dorsal or posterolateral approach and instrumentation can be combined with ventral methods. By using the primary anterolateral approach, one can reduce malalignment at the site where it is needed. Decompression can be carried out where it is truly necessary. One can give support within the segment of movement at the logical place from a biomechanical point of view: the weight bearing part, i.e., the anterior ring. By excision of the injured bony and ligamentous tissue, motion in the damaged segment of movement is eliminated, the original height is restored by grafting, and at the same time the load-bearing capacity of the fractured area is repaired. By applying Zielke instrumentation one can compress the grafts in accordance with modern views on fracture treatment. This "philosophy" is illustrated with case histories and a decision making flow chart.

Adolescent↗

The place of the CT scan in the three concept view (TCV) of the low back pain syndrome. A preliminary survey.

From the historical lines along which our thinking about low back pain developed, three concepts can be deduced: radicular, stenotic and axial. The patient with a low back pain syndrome (LBS) should be seen with this three concept view (TCV) in mind. Modern insight into the degenerative process of the low back supports this concept. The clinical syndromes illustrating these concepts, radicular syndromes, Neurogenic Peripheral Intermittent Claudication (NPIC), and axial low pack pain, can intermingle. To determine the place of the CT scan in the process of diagnosis of the LBS, we carried out a total of 56 CT-examinations on about 200 low back patients with various indications. The results are discussed. In addition to radiological suppositions, NPIC plays an important part in deciding whether or not to perform a CT scan.

Adult↗

A scanning electron microscopic (SEM) study of the re-endothelialization of the carotid end-to-side anastomosis in the rat.

A carotid end-to-side anastomosis was made on 25 male Wistar rats (mean weight 197.8 g). At different time intervals, from 0 to 21 days after the operation, the animals were sacrificed. The anastomosis was exposed, the aorta was cannulated, and the animals were perfused at a constant pressure of 80 mm Hg with a 2 1/2% glutaraldehyde solution. The anastomoses were taken out for further SEM and light microscopic (LM) study. The SEM results indicate that after the acute platelet-fibrin reaction in the first 48 hours the suture line itself becomes reendothelialized after 4 days. On the stitches, however, (EthilonR 11 X 0, 2871 G, BV7 needle) after two days a cellular population was seen, consisting of leucocytes transforming into flattened cells. The morphology of these cells and their role in the regeneration of endothelium is discussed. This study gives evidence to the possibility of a blood-borne genesis of endothelial cells in vivo.

Animals↗

Re-endothelialization of microvascular carotid end-to-side anastomosis in the rat.

A carotid end-to-side anastomosis was performed on 25 male and female Wistar rats (mean weight 197.8 gm). The animals were sacrificed at time intervals varying from 0 to 21 days after the operation. The anastomosis was exposed, the aorta cannulated, and the animals perfused with a 2.5% buffered glutaraldehyde solution at a constant pressure of 80 mm Hg. The anastomoses were removed for scanning electron microscopic (SEM) and light microscopic studies. The SEM results indicate that after the acute platelet-fibrin reaction in the first 48 hours, the suture line itself becomes re-endothelialized after 4 days. On the stitches, however, a cellular population consisting of leukocytes transforming into flattened cells was seen after 2 days. The morphology of these cells and their role in the regeneration of endothelium is discussed. This study presents evidence supporting a blood-borne genesis of endothelial cells in vivo.

Animals↗

[Neck injuries].

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Cervical Vertebrae↗