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Biomedical subjects

P Vink

Publications and source records attributed to P Vink.

At least 19 recordsLinked to original sources
PubMed2006

Association between objective and subjective measurements of comfort and discomfort in hand tools.

In the current study, the relationship between objective measurements and subjective experienced comfort and discomfort in using handsaws was examined. Twelve carpenters evaluated five different handsaws. Objective measures of contact pressure (average pressure, pressure area and pressure-time (P-t) integral) in static and dynamic conditions, muscle activity (electromyography) of five muscles of the upper extremity, and productivity were obtained during a sawing task. Subjective comfort and discomfort were assessed using the comfort questionnaire for hand tools and a scale for local perceived discomfort (LPD). We did not find any relationship between muscle activity and comfort or discomfort. The P-t integral during the static measurement (beta=-0.24, p<0.01) was the best predictor of comfort and the pressure area during static measurement was the best predictor of LPD (beta=0.45, p<0.01). Additionally, productivity was highly correlated to comfort (beta=0.31, p<0.01) and discomfort (beta=-0.49, p<0.01).

Adult↗
PubMed2005

Identifying predictors of comfort and discomfort in using hand tools.

The aim of the study was to identify predictors of comfort and discomfort in using hand tools. For this purpose, the comfort questionnaire for hand tools (CQH) was developed based on the results of a previous study. In the current study, four screwdrivers were evaluated on comfort (expected comfort at first sight and comfort after short time use) using the CQH and discomfort (local perceived discomfort). The results showed that expected comfort at first sight was predicted by aesthetics. Additionally, functionality and physical interaction, and adverse body effects were the major predictors of overall comfort after short time use. Discomfort was predicted by adverse body effects only. It is concluded that comfort and discomfort in using hand tools have partly the same underlying factors: discomfort feelings also affect the comfort experience.

Adult↗
PubMed2005

Enhancing the impact of ergonomics interventions.

The aim of this paper was to provide recommendations for ergonomists involved in project design and evaluation. Twelve research and consultancy projects involving ergonomics interventions in a variety of settings in The Netherlands were analysed to identify factors important to success. Projects included participatory and non-participatory cases. Eight factors were identified for successful project design and for demonstrating project effectiveness.

Community Participation↗
PubMed2004

Identifying factors of comfort in using hand tools.

To design comfortable hand tools, knowledge about comfort/discomfort in using hand tools is required. We investigated which factors determine comfort/discomfort in using hand tools according to users. Therefore, descriptors of comfort/discomfort in using hand tools were collected from literature and interviews. After that, the relatedness of a selection of the descriptors to comfort in using hand tools was investigated. Six comfort factors could be distinguished (functionality, posture and muscles, irritation and pain of hand and fingers, irritation of hand surface, handle characteristics, aesthetics). These six factors can be classified into three meaningful groups: functionality, physical interaction and appearance. The main conclusions were that (1) the same descriptors were related to comfort and discomfort in using hand tools, (2) descriptors of functionality are most related to comfort in using hand tools followed by descriptors of physical interaction and (3) descriptors of appearance become secondary in comfort in using hand tools.

Consumer Behavior↗
PubMed2004

Dead flower buds of pear: effect of tree growth control, and Alternaria alternata as causal agent.

Dead (dormant) flower buds of pear is an important phenomenon in pear production in the Netherlands. Vigourous or unbalanced tree growth and Pseudomonas syringae pv. syringae are mentioned as likely causes of dead flower buds. Several tree growth control treatments including ethephon. Regalis (Prohexadione-Ca) and root pruning were evaluated. Regalis increased disease incidence. The plant stimulant (foliar fertilizer) Resistim (potassium phosphonate) reduced disease incidence. Pseudomonas syringae pv. syringae was occasionally isolated from diseased flower buds. However, Alternaria alternata was nearly always isolated from diseased buds. Indicating a strong relation between this fungus and dead flower buds of pear.

Alternaria↗
PubMed2003

Reasons for adopting technological innovations reducing physical workload in bricklaying.

In this paper the adoption of technological innovations to improve the work of bricklayers and bricklayers' assistants is evaluated. Two studies were performed among 323 subjects to determine the adoption of the working methods, the perceived workload, experiences with the working methods, and the reasons for adopting the working methods. Furthermore, a comparison of the results of the studies was made with those of two similar studies in the literature. The results show that more than half of the sector adopted the innovations. The perceived workload was reduced. The employees and employers are satisfied with the working methods and important reasons for adoption were cost/benefit advantages, improvement of work and health, and increase in productivity. Problems preventing the adoption were the use of the working methods at specific sites, for instance in renovation work. The adoption of the new working methods could perhaps have been higher or faster if more attention had been paid to the active participation of bricklayers and bricklayers' assistants during the development of the new working methods and to the use of modern media techniques, such as the Internet and CD/DVD.

Construction Materials↗
PubMed2003

Aspects to improve cabin comfort of wheel loaders and excavators according to operators.

Comfort plays an increasingly important role in interior design of earth moving equipment. Although research has been conducted on vehicle interiors of wheel loaders and excavators, hardly any information is known about the operator's opinion. In this study a questionnaire was completed by machine operators to get their opinion about aspects which need to be improved in order to design a more comfortable vehicle interior. The results show that almost half of the operators rate the comfort of their cabin "average" or "poor". According to the operators, cab comfort of wheel loaders can be increased by improving seat comfort. Besides improving seat comfort, cabin comfort of excavators can be improved by changing the cab design (including dimensions, ingress/egress), view, reliability, and climate control.

Equipment Design↗
PubMed2002

Validating a framework for participatory ergonomics (the PEF).

Participatory ergonomics is reported in an increasing number of case studies, but there is little evidence of emerging supportive theory and relatively little generic advice or guidance. The paper describes an effort to provide clarity and organization to the field of participatory ergonomics. A framework has been developed to define a range of different participatory ergonomics initiatives, establishing a number of levels at which to operate. This participatory ergonomics framework (the PEF) was validated through retrospective description of seven independently conducted case studies and through peer evaluation. The exercise suggests that the PEF can be used as a first basis to produce practical guidance on participatory ergonomics programmes.

Community Participation↗
PubMed2001

Antiretroviral resistance mutations among pregnant human immunodeficiency virus type 1-infected women and their newborns in the United States: vertical transmission and clades.

To assess the impact of antiretroviral resistance on perinatal transmission prevention efforts, human immunodeficiency virus type 1 (HIV-1) genotypic resistance testing was done for 220 HIV-1-infected, zidovudine (AZT)-exposed pregnant women and 24 of their infected infants. The women were prospectively enrolled in 4 US cities in 1991-1997. Phylogenetic and sequencing analyses revealed 5 women with non-clade B infections traced to western African origins. AZT-associated mutations were detected in 17.3% of pregnant women, whereas genotypic resistance to nonnucleoside reverse-transcriptase inhibitors and protease inhibitors was infrequent. No significant association was detected between perinatal transmission and the presence of either AZT or nucleoside reverse-transcriptase inhibitor resistance-associated mutations. AZT resistance mutations were detected in 2 (8.3%) neonatal samples, but the mutation pattern was not identical to the mother's. Although no effect of viral resistance on mother-infant transmission was demonstrated, the advent of more-potent drug classes and the potential for the rapid emergence of resistance warrant prospective surveillance.

Anti-HIV Agents↗
PubMed2001

Maternal characteristics associated with antenatal, intrapartum, and neonatal zidovudine use in four US cities, 1994-1998.

OBJECTIVES: To evaluate implementation of 1994 United States Public Health Service guidelines for zidovudine (ZDV) use in HIV-infected women and their newborns by describing the prevalence of use of perinatal ZDV and other antiretrovirals and by investigating determinants of not receiving perinatal ZDV. DESIGN/METHODS: The Perinatal AIDS Collaborative Transmission Study is a prospective cohort study designed to collect information related to mother-to-child HIV transmission that was conducted in New York City (NY), Newark (NJ), Baltimore (MD), and Atlanta (GA), U.S.A. The current analysis was restricted to infants born between July 1994 and June 1998. RESULTS: Utilization rates for antenatal, intrapartum, and neonatal ZDV increased from 41% to 70% during the 4-year period. Use of combination antiretrovirals increased from fewer than 2% of women in 1994 to 1995 to 35% in 1997 to 1998. Antenatal and neonatal ZDV use increased each year, but intrapartum ZDV use reached a plateau after 1996. Mother-infant pairs with the following characteristics were less likely to have received a complete 3-part ZDV regimen: older maternal age, CD4 count >500 cells/microl, preterm birth, cocaine or heroin use during pregnancy, positive newborn drug screen test result, and smoking or alcohol use during pregnancy. By multivariate logistic regression adjusted for hospital and year of birth, cocaine or heroin use during pregnancy (odds ratio [OR], 2.3; 95% confidence interval [CI], 1.6-3.3), maternal CD4 count (OR, 0.4; 95% CI, 0.2-0.8; comparing <200 with >500 cells/microl), and preterm birth (OR, 1.6; 95% CI, 1.1-2.5) remained independently associated with not receiving the complete ZDV regimen. CONCLUSIONS: ZDV use by pregnant HIV-infected women and their infants has increased dramatically since publication of the 1994 guidelines. Nevertheless, women who abuse substances, give birth preterm, or have less advanced immunosuppression, were at substantial risk of not receiving the complete ZDV regimen.

Adult↗
PubMed2001

Towards successful physical stress reducing products: an evaluation of seven cases.

Lifting, carrying, pushing and pulling at work are assumed to be related to increased risks of musculoskeletal injury, mainly in the low back and shoulder region. The implementation of products to reduce the physical load in heavy work is a well-known strategy to attack this problem. The success of these products depends not only on the product itself, but also on the process of product development and implementation. In this paper, seven cases are described where products have been developed to reduce the physical load on scaffolders, bricklayers, bricklayer's assistants, roofworkers, aircraft loaders, glaziers and assembly line workers. These products are described with special reference to the physical load problem in the occupational task, the process of product development, the nature of the product, the potential effects on physical load and the opinion of workers. From these cases, a list of key factors in product development contributing to the success of a product is composed. These concern among others a direct participation of workers, a wide analysis of risks, an analysis of potential negative side effects, and a systematic stepwise approach.

Equipment Design↗
PubMed1998

Impact of zidovudine use on risk and risk factors for perinatal transmission of HIV. Perinatal AIDS Collaborative Transmission Studies.

OBJECTIVES: To evaluate the impact of perinatal zidovudine use on the risk of perinatal transmission of HIV and to determine risk factors for transmission among women using perinatal zidovudine. DESIGN: Prospective cohort study of 1533 children born to HIV-infected women between 1985 and 1995 in four US cities. METHODS: The association of potential risk factors with perinatal HIV transmission was assessed with univariate and multivariate statistics. RESULTS: The overall transmission risk was 18% [95% confidence interval (CI), 16-21]. Factors associated with transmission included membrane rupture > 4 h before delivery [relative risk (RR), 2.1; 95% CI, 1.6-2.7], gestational age < 37 weeks (RR, 1.8; 95% CI, 1.4-2.2), maternal CD4+ lymphocyte count < 500 x 10(6) cells/l (RR, 1.7; 95% CI, 1.3-2.2), birthweight < 2500 g (RR, 1.7; 95% CI, 1.3-2.1), and antenatal and neonatal zidovudine use (RR, 0.6; 95% CI, 0.4-0.9). For infants exposed to zidovudine antenatally and neonatally, the transmission risk was 13% overall but was significantly lower following shorter duration of membrane rupture (7%) and term delivery (9%). The transmission risk declined from 22% before 1992 to 11% in 1995 (P < 0.001) in association with increasing zidovudine use and changes in other risk factors. CONCLUSIONS: Perinatal HIV transmission risk has declined with increasing perinatal zidovudine use and changes in other factors. Further reduction in transmission for women taking zidovudine may be possible by reducing the incidence of other potentially modifiable risk factors, such as long duration of membrane rupture and prematurity.

Adult↗
PubMed1998

Thymic dysfunction and time of infection predict mortality in human immunodeficiency virus-infected infants. CDC Perinatal AIDS Collaborative Transmission Study Group.

The effect of human immunodeficiency virus (HIV)-induced thymic dysfunction (TD) on mortality was studied in 265 infected infants in the CDC Perinatal AIDS Collaborative Transmission Study. TD was defined as both CD4 and CD8 T cell counts below the 5th percentile of joint distribution for uninfected infants within 6 months of life. The 40 HIV-infected infants with TD (15%) had a significantly greater mortality than did the 225 children without TD (44% vs. 9% within 2 years). Infants with TD infected in utero had higher mortality than did those infected intrapartum (70% vs. 37% within 2 years), while no significant difference was noted between infants without TD with either mode of transmission. The TD profile was independent of plasma virus load. Virus-induced TD by particular HIV strains and the time of transmission are likely to explain the variation in pathogenesis and patterns of disease progression and suggest the need for early aggressive therapies for HIV-infected infants with TD.

CD4 Lymphocyte Count↗
PubMed1997

Improving office work: a participatory ergonomic experiment in a naturalistic setting.

In a Department of Salary Records where VDU tasks were performed at a high work rate, a participative ergonomic study was undertaken. First, the 'old' workplace was investigated for all 45 employees. Work stations appeared to be of poor ergonomic quality. Second, 12 employees participated in an experiment at the actual workplace. Objective and subjective effects were recorded under three conditions: the 'old' workplace, the recommended ('ideal') workplace, and the self-chosen workplace. Based on this data 'ergonomic' furniture and additional accessories were ordered and all 45 employees received tailor-made instructions and training with respect to their ideal workplace. After 5 months data for their 'objective' workplaces and subjective reports about the workplace were recorded. The study focuses on the comparison of the three conditions and of the two groups of employees: 33 who received thorough instruction and training only, and 12 who also participated in the experiment. Both objective and subjective improvements are demonstrated in the recommended situation when compared to the original situation. Although some employees deliberately chose to deviate from the recommended situation--owing to task and individual characteristics--self chosen workplaces still constituted a much better workplace in comparison to the old workplace. The 12 employees who participated in the experiment chose a better self-preferred workplace when compared to their 33 colleagues. It is concluded that experimental measurements in a naturalistic setting may contribute significantly to workplace improvements (1) by presenting adequate and 'objective' information for workplace improvement and ergonomic redesign, and (2) as a change agent itself, that is as an 'intensified treatment'.

Adult↗
PubMed1996

Lack of increased risk for perinatal human immunodeficiency virus transmission to subsequent children born to infected women.

BACKGROUND: Little is known about whether a woman's risk of transmitting HIV perinatally increases over time and whether the infection outcome of a previous child affects the risk of transmitting HIV to subsequent children. METHODS: We analyzed data from 114 prospectively followed women who gave birth to at least 2 children after becoming infected with HIV to determine the risk for perinatal HIV transmission to these sibling pairs. RESULTS: The median interval between sibling births was 19 months. HIV infection occurred in 19 (17%) older siblings and 20 (18%) younger siblings (P = 0.87). Two (11%) of the 19 children with infected older siblings were infected compared with 18 (19%) of the 95 children with uninfected older siblings (P = 0.86). The risk for transmission to younger siblings was not associated with the interval between deliveries of the two siblings. CONCLUSIONS: These data do not demonstrate that an HIV-infected woman's risk of transmitting HIV perinatally increases with time, although the observed interpregnancy interval was relatively short. The risk for perinatal transmission does not appear to be affected by the infection outcome of previous children. These findings may be useful for counseling HIV-infected women about their risk of transmitting HIV perinatally.

Child↗
PubMed1994

Evaluation of a sitting aid: the back-up.

The effects of a portable back support, the Back-Up, were tested in 28 variables. Both subjective and objective physical load measures were recorded during sitting with and without Back-Up, most of them during VDU work. The main result was that the posture of the upper back and neck/head was improved by the Back-Up. However, the knee straps induced unacceptable high pressure and increased significantly the discomfort in the legs. Based on these results the Back-Up was modified: the contact area between the strap and the knee was enlarged. This modified Back-Up was tested again for 13 variables with 10 new subjects. The knee pressure turned out to be acceptable and the discomfort was equal to sitting without the Back-Up. Based on this research the Back-Up is considered as a possible addition to more fundamental ergonomic improvements such as adjustable furniture and variation between sitting, standing and walking tasks, especially for improvement of the neck load. However, the Back-Up should not replace proper ergonomic workstation and work organization design or a backrest on the chair. Furthermore, the Back-Up should not be made obligatory, and it should be worn only for a part of the day, because it limits variation in postures.

Journal Article↗
PubMed1992

Application problems of a biomechanical model in improving roofwork.

The compression force during traditional roofwork and improved roofwork was calculated by means of a two-dimensional static biochemical model. The improvement resulted in a 30% reduction in compression force, but also influenced factors which cannot be incorporated into the model but may cause back injuries. The frequency and velocity of movements were reduced and the trunk torsion increased. It is recommended that in further development this trunk torsion should be avoided. For valid application of biomechanical models in ergonomics, further research is needed. Priority should be given to epidemiologic research to establish the influence of compression force, trunk torsion and latero-flexion, frequency and velocity of movement on the development of lumbar injuries.

Journal Article↗