Search PubMed⌕ Search

Biomedical subjects

P Vicente

Publications and source records attributed to P Vicente.

At least 19 recordsLinked to original sources
PubMed1992

Carboplatin, methotrexate, and vinblastine in patients with bladder cancer who were ineligible for cisplatin-based chemotherapy.

BACKGROUND: A Phase II trial with a new regimen of methotrexate, carboplatin, and vinblastine (M-CAVI) was conducted for patients with bladder cancer who could not receive cisplatin-based chemotherapy. METHODS: Treatment consisted of methotrexate (30 mg/m2) on days 1, 15, and 22; carboplatin (300 mg/m2) on day 2; and vinblastine (3 mg/m2) on days 2, 15, and 22, scheduled at 28-day intervals. The dosage of carboplatin was adjusted for creatinine clearance. Twenty-five patients with metastatic (n = 9) or locally advanced or locoregional bladder cancer with a poor prognosis (n = 16) were treated with M-CAVI. Fifteen patients had abnormal serum creatinine levels, 4 had a low performance status, 3 had cardiac disease, and 3 were older than 70 years old. RESULTS: Among 23 patients assessable for clinical response, the response rate was 48%. The median duration of response for metastatic disease was 7 months. Among nine patients assessable for pathologic response, there were two complete responses and three partial responses. The toxic effects have been moderate. CONCLUSIONS: M-CAVI is an active and well-tolerated regimen that can be used in patients with bladder cancer who are ineligible to receive cisplatin-based chemotherapy.

Adult↗
PubMed1992

Endobronchial metastases in colorectal adenocarcinoma.

Between 1982 and 1990, 2388 bronchoscopic examinations were carried out in patients with cancer in our hospital. A diagnosis of endobronchial metastasis was established in 30 patients (2.09%), with the following primary tumors in descending order of frequency: breast, large bowel, melanoma, neuroblastoma, leiomyosarcoma and endometrial. Despite the rarity of endobronchial metastases secondary to colon adenocarcinoma, we were able to study 3 cases from our Center. In one case the diagnosis of endobronchial metastasis was simultaneous with that of the primary tumor, and in the other 2 this metastatic complication occurred 16 and 42 months, after the original diagnosis. When this complication occurred, the stage of the disease was advanced in all 3 cases: 2 were Dukes' stage C and one stage D. Although this metastatic location usually implies a very negative prognosis as regards life expectancy, it did not seem to significantly reduce the latter in our patients.

Adenocarcinoma↗
PubMed1992

[Bladder neoplasm in a patient with panarteritis nodosa treated with cyclophosphamide].

Cyclophosphamide is used both in the treatment of malignant and non-malignant diseases. Urinary neoplasms secondary to its use have been described. We discuss the case of a patient with panarteritis nodosa treated with cyclophosphamide during 63 months, with a total dose of 210 grams, and that showed a bladder neoplasm 8 years after beginning of the treatment. In patients receiving a total dose of cyclophosphamide over 85 grams, a follow-up of ten years minimum should be performed aimed to the early detection of secondary neoplasms.

Adrenal Cortex Hormones↗
PubMed1992

Meningeal fibrosarcoma: a case report and review of the literature.

Meningeal Fibrosarcoma (MF) accounts only for 0.5% of the brain tumors. Since the clinical manifestations and radiologic findings are non-specific, the diagnosis can only be achieved by pathological examination of surgically removed specimens. MF are tumors that behave locally very aggressively and respond poorly to treatment, with reported median survivals ranging from 6 to 15 months. We report a new case of MF describing the peculiar onset as a slow growing mass in scalp with bone destruction and without neurological clinical findings.

Adult↗
PubMed1992

[Spinal cord compression as a primary manifestation of occult thyroid carcinoma].

Metastatic disease is the first clinical manifestation of differentiated thyroid carcinoma (DTC) in less than 5% of cases. Bone metastases as the first sign of DTC are associated with a poor prognosis, both for being resistant to treatment and for complications due to them. Spinal cord compression is a rare development in DTC, which may present late in the course of the disease. An initial presentation of DTC with a spinal cord compression is an extremely rare condition.

Adenocarcinoma↗
PubMed1991

[Cerebral metastases in adenocarcinoma of the colon].

Between 25% and 35% of all patients with cancer, will develop metastases to the brain. Gastrointestinal neoplasms are responsible for 8% of all cases of metastatic brain involvement. The frequency of brain metastases in carcinoma of the colon ranges from 0.3 to 6%, and this location is usually accompanied by metastatic involvement of the lung and liver. Cerebral metastatic lesions are uncommon in colon cancer, and are usually a late manifestation of the disease. Because of the rarity of this complication, we report a case of metastatic colon adenocarcinoma to the brain, and we review the literature on this subject.

Adenocarcinoma↗
PubMed1990

Carbon and polyester fibers as a scaffold for bone repair. Studies of segmentary implants in the rabbit radius.

To determine the function in the repair of bone defects, implants of carbon and polyester fibers of comparable dimensions were used to replace a 2-cm long segment of the radius of 29 rabbits. The healing process was analyzed by scintigraphic, radiographic, and histologic methods after periods of 15-90 days, comparing the results with a control group without implants. In the rabbit, carbon and polyester fibers did not induce repair of bone defects, although they did permit invasion of the implant during the later stages.

Animals↗
PubMed1989

Presence of melatonin in the umbilical cord blood of full-term human newborns.

The present study was designed to determine whether melatonin circulates in the umbilical cord blood of healthy human newborns and whether the concentrations of this hormone follow a circadian rhythm at birth. Umbilical cord blood was collected from full-term human newborns at the time of delivery. Serum melatonin was extracted with diethylether and determined by radioimmunoassay by using radioiodinated melatonin and rabbit antimelatonin antiserum. Significant amounts of melatonin were detected in the sera obtained from umbilical cord blood. When serum melatonin concentrations of human newborns were represented over 6-h periods or hour by hour over the 24 h of 1 d, similar hormone concentrations were found consistently. These results indicate that melatonin is present in quite high levels in the umbilical cord blood, which may be, at least in part, of maternal origin. Also, our results suggest the absence of a melatonin circadian rhythm in human newborns, which may reflect an immaturity of the components involved in melatonin synthesis.

Circadian Rhythm↗
PubMed1985

Surgical treatment of the non-functional spastic hand.

The authors use Zancolli's classification for the surgical evaluation of the spastic upper limb. The paper describes the surgical technique used by the authors in the treatment of twenty-six patients grade III, having a "non-functional hand". After justifying the treatment, the technique is described which includes a time for the elbow to relax the antebrachii flexors and M. Epitrochlearis, a time for defunctioning the pronators and relaxing the flexors by intramuscular tenotomy. Transplantation of the flexors of the wrist is carried out to the extensors of the wrist and fingers. The thumb-in-palm is corrected by a tenotomy of the Adductor and Flexor Pollicis Brevis and transplanting the Brachioradialis to the tendons of the first dorsal compartment.

Hand↗
PubMed1981

Partial trisomy 20.

A child with a facial dysmorphy and congenital malformations, showed in the chromosome analysis a partial trisomy of chromosome 20. This anomaly, resulted from a maternal translocation t(11;20), (q35;q11).

Abnormalities, Multiple↗
PubMed1979

Familial translocation t(10;21)(q22;q22).

A family is described with a translocation t(10;21)(q22;q22) transmitted through three generations. This family was studied for the apparition of several miscarriages and two sisters with multiple malformations. Both children had a probably partial trisomy of chromosome 10 and a monosomy of chromosome 21 due to a maternal adjacent-2 meiotic segregation.

Abnormalities, Multiple↗