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Biomedical subjects

P Viars

Publications and source records attributed to P Viars.

At least 235 records · Page 13Linked to original sources

[Early enteral nutrition in gastrointestinal surgery].

In a series of twenty similar patients, having a healthy small intestine and having undergone elective surgery, two protocols of alimentation were studied. Beginning from the 8th post-operative hour, enteral alimentation is carried out by means of access to the jejunum and continued for ten days. The volume of liquid in the alimentary canal is progressively increased allowing the intravenous route to be stopped on average after 3,9 days. The high amount of the nitrogen and calory supply limits the post-operative nitrogen catabolism and rapidly restores a positive nitrogen balance. In other respects the weight loss is less than 2%, the biological constants are stable and no serious complications are linked with this technique. The early use of GI tract deals with the alimentational and electrolyte needs of the post-operative patient and diminishes the risks of iatrogenic complications of long term intravenous infusions. Relying on experimental data proving the absence of cessation of peristalsis of the small intestine in the immediate post-operative period and also the continuation of its capacity for absorption, this work demonstrates the possibility of early enteral alimentation. A better knowledge of the indications and contra-indications of this technique of feeding, of its methods of administration, and of the capabilities of absorption of the alimentary canal, must extend its indications to the high risk operative patients.

Adult↗

[Treatment of isolated postoperative respiratory complications by constant positive pressure in spontaneous ventilation].

Positive pressure at the end of expiration (PEEP) applied in spontaneous ventilation (CPAP) has the same ventilatory effects as in controlled ventilation without the harmful actions. Few studies have described the use of CPAP in severe isolated postoperative respiratory insufficiency. CPAP was applied in 16 patients free of chronic bronchopulmonary disease, aged between 22 and 82 years, and suffering after major thoracic and/or abdominal surgery from isolated acute respiratory insufficiency as defined by clinical, blood gas and rediological criteria. CPAP was applied with mask alone (n = 5) or by nasotracheal intubation followed by mask (n = 11). PEEP was regulated at +1.7 to +2.94 KPa (+ 12 to 30 cm H2O) in order to obtain a PaO2/FIO2 greater than or equal to 300. Alveolar ventilation was assessed by capnography. Improvement was marked in six days : the PaO2/FIO2 ratio at nil PEEP fell from 129 +/- 3.2 to 3.73 +/- 6.5 (mean +/- SD), the score of interstitial and alveolar opacities from 25 to 4 and the atelectasis score from 10 to 1. These results show the efficacy of CPAP in the early treatment of isolated postoperative acute respiratory insufficiency.

Humans↗

[External pancreatic fistulas. Medical treatment (author's transl)].

Ten patients treated for pancreatic fistulas have been reviewed. They all received a nutritional support via a jejunal tube in association with an external drainage of the fistulous tract. Enteral hyperalimentation do not stimulate external pancreatic secretion and all fistulas closed up spontaneously within three months (mean 55 days) without major complications. In one case fistula reappeared two months later and needed surgical procedure.

Adolescent↗

[Buprenorphine. Haemodynamic study (author's transl)].

Haemodynamic effects of intravenous buprenorphine 3 microgram/kg were studied on nine subjects. Subjects were under controlled ventilation, and had a radial cannula and a Swan-Ganz catheter. Heart rate slowed up, from 109 +/- 23 to 96 +/- 18 at the 90th minute (p less than 0.02), and remained slightly depressed at the 4th hour. Mean arterial blood pressure fell from 91 +/- 17 to 82 +/- 18 mm Hg (p less than 0.001): the difference remained statistically significant until the 3th hour. Cardiac index fell from 4.16 +/- 0.67 to 3.55 +/- 0.63 l/mn/m2 at the 60th minute (p less than 0.001). Thus the haemodynamic effects of buprenorphine exist but are light.

Adolescent↗

[Droperidol. Action on hemodynamic and oxygen consumption changes (author's transl)].

Hemodynamic and oxygen consumption changes following general anesthesia were studied in 11 patients who did and in 11 patients who did not received droperidol at the end of operation. Both group were similar with respect to age, duration of anesthesia, doses of anesthetic drugs, and hemodynamic and oxygen consumption values immediately at the end of operation. The highest oxygen consumption measurements which were selected as representative of the maximal metabolism of the recovery period showed that the following parameters were lower in the droperidol group than in the non-droperidol group: oxygen consumption (162 +/- 12 and 238 +/- 19 ml/min/m2 respectively), cardiac index (3.0 +/- 0.2 and 4.4 +/- 0.4 l/min/m2), mean arterial pressure (11 +/- 6 and 129 +/- 5 torr), stroke index (27 +/- 3 and 46 +/- 4 ml/m2) left ventricular stroke work index (38 +/- 5 and 77 +/- 8 gm/m2) and PaCO2 (39 +/- 2 and 49 +/- 2 torr). The measurements performed after extubation were similar in both groups. These data show a metabolic and hemodynamic stabilizing effect of droperidol during recovery which may be useful in high-risk patients.

Anesthesia↗

[Comparison between the analgesic effects of fentanyl and morphine in conscious man (author's transl)].

Fentanyl citrate is administered intramuscularly at increasing doses to patients suffering from an intense pain in the facial or trigeminal nerves territory. Fentanyl induces a very intense analgesia which develops during the hour following the administration. The intensity and the duration of the effect are dose related. Compared to that of morphine chlorhydrate, in the same conditions, the analgesia induced by fentanyl citrate is much less intense than expected: fentanyl seems to be only 25 times more potent than morphine. Furthermore, the observed duration of action of fentanyl makes it impossible to be still classified with the short time acting analgesics: with equianalgesic doses, morphine and fentanyl have the same time of initiation and the same duration of action. As observed, the time of the clinically useful analgesia is longer than 3 hours after injection of 0.006 mg/kg of fentanyl or of 0.150 mg/kg of morphine.

Female↗

[Comparison between the side-effects of fentanyl and morphine in conscious man (author's transl)].

Fentanyl citrate or morphine chlorhydrate are injected intramuscularly at increasing doses to patients suffering from intense pain in the facial or trigeminal nerves territory: --fentanyl = 0.0015, 0.003, 0.006 mg/kg; --morphine = 0.100, 0.150, 0.200 mg/kg. The clinically observed side-effects are noted at regular time during the three hours following the injection. Fentanyl induces a drop in ventilation similar in duration to that of morphine, but it is more intense. Fentanyl induces less vomiting, but more euphoria than morphine and the sedation is the same in frequency and intensity with both drugs. The only difference of clinical importance concerns the cardio-vascular effects: morphine induces a constant, dose-related hypotension as that of fentanyl, at equianalgesic doses, is negligible.

Adult↗

[Comparison between the analgesic effects of buprenorphine and morphine in conscious man (author's transl)].

Morphine chlorhydrate and buprenorphine chlorhydrate are given intramuscularly at increasing doses to patients suffering from intense pain in the facial or trigeminal nerves territory. No other drugs are used. The diverses groups of ten patients received respectively: --morphine: 0.100, 0.150, 0.200 mg/kg; --buprenorphine: 0.0015, 0.003, 0.006 mg/kg. On the whole, the analgesia is induced after a short time and is more durable, more intense as the dose is increased. Yet, concerning buprenorphine, the analgesia is not more intense with the 0.006 mg/kg dose, than with the 0.003 mg/kg dose. This phenomenon, if confirmed, would be an important limitation for the clinical use of this drug. For equianalgesic doses buprenorphine and morphine give an analgesia similar in time of initiation and in duration.

Aged↗

[Comparison between the side-effects of buprenorphine and morphine in conscious man (author's transl)].

Side-effects of increasing doses of morphine (0.100, 0.150, 0.200 mg/kg) and buprenorphine (0.0015, 0.003, 0.006 mg/kg), given intramuscularly, are clinically observed in conscient subjects suffering from intense pain in the facial or trigeminal nerves territory. Buprenorphine induces a drop in ventilation even with the lower doses, which persists for 120-180 minutes. This effect is more important after the injection of an equianalgesic dose of morphine. The same phenomenon is observed for the drop in heart rate and for the hypotension, which remained in all cases very slight. The central side-effects are of the same nature with buprenorphine and with morphine. On the whole this phenomenon appears with the same frequency with both drugs, especially for drowsiness and sleep, for nausea, vomiting and dizziness. Yet, the patient under buprenorphine becomes more frequently confused and agitated. Lastly, a state of euphoria can occur which might be feared to be related to a drug-addict activity of buprenorphine.

Adult↗

[Doppler effect and the Swan-Ganz catheter. Advantage in diagnosis and treatment of gaseous embolism by neurosurgical procedure (author's transl)].

During the neurosurgical procedure in the sitting position a prospective study was performed with a Swan-Ganz catheter on 99 subjects. Gaseous embolism occured in 11 subjects (11%). The frequency increased twofold in the surgery of pontocerebellar angle tumors. Haemodynamic study of 10 gaseous embolisms showed a rise in pulmonary arterial pressure (15.3 +/- 5.2 to 32.4 +/- 32.4 +/- 7.7 mm Hg; p < 0.005) with a rise in pulmonary resistances (22 +/- 1.2 to 9.0 +/- 3.1 units; p < 0.005) and in right ventricular systolic work index (7.8 +/- 1.3 to 14.4 +/- 6.3 gm/m2; p < 0.02). The fall in mean arterial blood pressure was inconstant and moderate (89 +/- 19 to 78 +/- 23 mm Hg; p < 0.05) as was the fall in cardiac output (5.6 +/- 0.9 to 5.0 +/- 0.8 l/min; p < 0.01). Increasing FIO2 hid hypoxemia but, in five subjects, the intrapulmonary shunt rose from 7 to 31%. The therapeutic aspects are reviewed.

Anesthesia↗

Cardiovascular response to the i.v. administration of morphine in critically ill patients undergoing IPPV.

The haemodynamic changes following the administration of morphine 0.15 and 0.30 mg kg-1 i.v. were studied in 11 patients, free from known cardiac disease. All patients were acutely ill and their lungs were being ventilated mechanically. In those patients receiving 0.15 mg kg-1, the only haemodynamic change was a slight and transitory decrease in the systolic arterial pressure. In contrast, several changes were observed in patients receiving 0.30 mg kg-1: an immediate and prolonged decrease in the cardiac index was noted along with transient decreases in heart rate, stroke volume index, arterial pressure and left stroke work index. These results suggest that the haemodynamic cost of morphine 10 mg is negligible but could be significant when 20 mg has been administered and must be weighed against its beneficial effects in the critically ill patient.

Adult↗

Early anuria prevention in human kidney transplantation. Advantage of fluid load under pulmonary arterial pressure monitoring during surgical period.

In human kidney transplantation, a high blood flow established through the graft immediately upon clamp release is usually associated with immediate satisfactory renal function. One hundred consecutive kidney transplant patients were thus provided with a large volume of fluid during surgery. To avoid pulmonary edema, fluid load was given under mean pulmonary arterial pressure (PAP) monitoring, and controlled ventilation was maintained during the early postoperative period. Whether initial PAP value was within normal range or elevated, all patients required an equivalent fluid load to reach the best hemodynamic condition upon clamp removal. The mean intraoperative fluid load consisted of 2406 +/- 968 ml of water with 22.8 +/- 9.4 g of sodium chloride, 5.9 +/- 1.8 units of albumin, and 2.6 +/- 1.8 units of packed red blood cells. Immediately before clamp release patients were given furosemide and mannitol. During the postoperative period, i.v. infusions consisted of water and sodium chloride (6 g/liter) to match urine output, provided that diuresis was equal to or above 400 ml/hr. If diuresis remained or decreased below this level, diuresis replacement was associated with PAP-controlled infusion of saline, albumin, and red blood cells if needed. Furosemide was eventually given if diuresis did not increase above 400 ml/hr with fluid loading. With this protocol a good early diuresis was established in 95% of the cases. Ten patients required dialysis before the 5th postoperative day, one of them because of fluid overload and anuria. Concurrently, a decreased mortality rate and an increased graft survival rate were observed.

Adolescent↗