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Biomedical subjects

P Varga

Publications and source records attributed to P Varga.

At least 73 records · Page 4Linked to original sources
PubMed1987

Glucose intolerance and insulin resistance with aging--studies on insulin receptors and post-receptor events.

The oral glucose tolerance test and immune reactive insulin level determination were performed on 100 non-obese healthy elderly and 40 young and middle-aged non-obese healthy subjects. In about 60% of the elderly an altered glucose tolerance test was found, but the insulin level was increased in the whole group of elderly subjects. This means an insulin-resistant state with aging. Further investigations were carried out to determine some possible causes of this insulin resistance. The chromium level in sera and granulocytes of elderly was significantly decreased as well as the insulin receptor numbers and the affinity to erythrocytes. In contrast, when the cyclic nucleotide levels were investigated in granulocytes under in vitro stimulation, an age-dependent increase of cAMP level was found and an unresponsiveness of cGMP, which ranged between mild and severe degrees. Concomitantly, all these changes found could contribute to the insulin resistance at the receptor and post-receptor levels with aging.

Adult↗
PubMed1986

Immunologic factors contributing to the initiation of labor--lymphocyte reactivity in term labor and threatened preterm delivery.

To obtain data on the immunologic events during labor, we investigated cytotoxic activity, progesterone-prostaglandin F2 alpha and prostaglandin E2 sensitivity of the lymphocytes in late pregnancy at early and late stages of labor and in the puerperium. In an attempt to investigate common determinants between the behavior of lymphocytes during labor and threatened preterm delivery, the same parameters of lymphocytes obtained from women with threatened preterm delivery were tested in parallel. At the beginning of labor, cytotoxic activity of the lymphocytes significantly increased and remained at a high level till the end of labor. A negative correlation (r = -0.803) was found between the increase of cytotoxicity and the duration of labor. High progesterone sensitivity of pregnancy lymphocytes decreased while low sensitivity to prostaglandin E2 increased during labor. Sensitivity of the lymphocytes to prostaglandin F2 alpha was similar in all of the groups examined. Except for prostaglandin E2 sensitivity all parameters of the lymphocytes obtained from women with threatened preterm delivery were similar to those of lymphocytes obtained during labor.

Cytotoxicity, Immunologic↗
PubMed1985

Food-induced thermogenesis in obese children.

In 11 obese children aged 12.5 (+/- 0.7) years with normal glucose tolerance and 7 lean, control children aged 11.9 +/- 0.7 years the preload resting energy expenditure and thermogenic response to a standardised meal was measured by indirect calorimetry. Preload energy expenditure was higher in obese children when expressed in absolute terms than in controls, but was not different when corrected for lean body weight. Four children with obesity of recent onset had lower food-induced thermogenesis and insulin response then seven overweight children with long-standing obesity. Food-induced thermogenesis and insulin response showed a significant positive correlation. It is concluded that food-induced thermogenesis is reduced in the early phase of childhood obesity but increased in the later phase when hyperinsulinaemia develops, pointing towards an important role of insulin in food-induced thermogenesis.

Adolescent↗
PubMed1985

Sacrococcygeal teratoma and normal alphafetoprotein concentration in amniotic fluid.

It is usually assumed that in the case of sacrococcygeal teratoma the concentration of alphafetoprotein in the amniotic fluid is increased. In the case reported here the AFP concentration in the amniotic fluid was found to be normal in spite of a large teratoma not covered with skin. Possible reasons for this are discussed and the histological characteristics of the tumour are reported. It is emphasised that this teratoma could not have been recognised antenatally by normal AFP screening, but was only possible by ultrasound examination.

Amniotic Fluid↗
PubMed1985

Body composition in elderly people. II. Comparison of measured and predicted body composition in healthy elderly subjects.

The predictive values of the equations of Moore et al. and Hume and Weyers and the measured values of body composition were compared in healthy, carefully selected aged and young subjects of both sexes. In the case of young subjects, these prediction equations seem to be adequate, even if this could not be affirmed with certainty by our results. The equations of Moore et al. were found not to be adequate for elderly males, while they were only suitable for the determination of intracellular components in elderly females.

Adult↗
PubMed1982

[Not Available].

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History of Pharmacy↗