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Biomedical subjects

P Vanderhoeft

Publications and source records attributed to P Vanderhoeft.

At least 37 records · Page 2Linked to original sources
PubMed1980

Aspergilloma in a necrotic bronchial adenocarcinoma.

A patient with an aspergilloma developing in a cavitary bronchial adenocarcinoma is presented. The case fulfilled the clinical, radiological and laboratory criteria of pulmonary mycetoma. A lobectomy was performed because of severe haemoptysis and the unknown aetiology of the cavitated lesion. Lung cancer was found to be the underlying process. This diagnosis had not been considered preoperatively because of the unusual radiological presentation of a polycystic lesion and because of the rare association of aspergilloma with bronchial carcinoma.

Adenocarcinoma↗
PubMed1979

Ventilation in dogs on cardiopulmonary bypass with and without lungs.

In 13 anesthetized or awake dogs, on cardiopulmonary bypass, we varied PaO2 and PaCO2 while continuously monitoring ventilatory responses and mechanics, to assess the dog's ability to maintain eupneic ventilation for any chemical drive. In a second group of 13 dogs on cardiopulmonary bypass we repeated the tests after removal of both lungs, to assess the importance of pulmonary feedback and mechanics. The VE/PO2 plot formed two hyperbolas, asymptotic to 39 Torr PO2 with lungs, and to 27 without; both intercepted zero ventilation near 200 Torr. Hyperoxic apnea occurred at, or below, PCO2 30 +/- 7 Torr under barbiturate and 20 +/- 4 Torr under morphine. Steady-state low PCO2 (10 Torr) turned off hypoxic drives as low as 20 Torr PO2. Empty-chest dogs had a low respiratory frequency (18 vs. 40), and near zero dynamic elastance; ventilatory work per minute and airway resistance were the same with and without lungs. Chest wall ventilatory responses are grossly independent of the presence of absence of lungs.

Airway Resistance↗
PubMed1976

Extracorporeal oxygenation with various experimental venoarterial bypasses during prolonged apnea.

This work compares various conventional venoarterial closed-chest circuits where satisfactory oxygenation of myocardium and brain in total apnea with extracorporeal circulation is concerned. Eleven dogs were studied during 3 hours of curare-induced apnea. We used single and double vena caval drainages connected to an oxygenator. A single-vein drainage yielded approximately 50 per cent and a double-vein drainage 75 per cent bypass. Two separate roller pumps fed arterialized blood variously into carotid and femoral arteries. In single-vein drainage, the oxygen partial pressure in the coronary artery was consistently poor and carotid oxygen partial pressure was poor for 100 per cent femoral infusion while more and more arterialized blood reached the carotid arteries in the other single-vein drainage circuits. In double-vein drainage, the coronary oxygen partial pressure for 100 per cent femoral infusion remained poor while, for the other circuit types, the coronary arteries received arterialized blood except where 100 per cent carotid infusion was concerned. The carotid oxygen partial pressure was sound for all groups in the double-vein drainage except for some obtained in 100 per cent femoral infusion. Consequently, where the bypass was large and the carotid and femoral arteries received a share of arterialized blood, both heart and brain received sound oxygenation.

Animals↗
PubMed1975

[Cardio-respiratory assistance with the extracorporeal membrane oxygenator for massive pulmonary embolism].

A 39 year old pneumectomized patient presents a massive pulmonary embolism, dies within 3 hours and is supported inefficiently by cardiac massage with recurrent mydriasis during 2 hours. At that time, under extracorporeal cardiopulmonary bypass with a membrane oxygenator, the cardiac activity recovers immediatly due to right decompression and coronary perfusion. The patient is conscious within 5 hours. The cardiopulmonary bypass with a membrane oxygenator appears to be the best therapy when the cardiac massage fails to restitute a normal myocardial function. No embolectomy was performed. The patient died when the bypass was stopped after 48 hours. We conclude that the prolonged peripheral extracorporeal bypass followed by embolectomy is the best therapy of pulmonary embolism.

Adult↗
PubMed1975

[Use of lande-edwards membrane oxygenators as artificial lungs].

Lande-Edwards membrane oxygenators were tested as artificial lungs in 6 dogs: the right heart directly perfused the oxygenators during an apneusis of one hour. During such a pulmonary by-pass right ventricular pressure doubles compared to initial value, with a moderate decrease in cardiac output; mean PO-2 rises from 40 to 67 mm Hg and PCO-2 decreases from 54 to 49 mm Hg through the oxygenator.

Animals↗
PubMed1975

Landé-Edwards membrane oxygenator without pump as total lung prosthesis.

Fourteen anesthetized dogs remained in apnea for 1 to 4 hours on total extracorporeal breathing through a Landé-Edwards membrane oxygenator (LEMO). The LEMO was directly perfused by the right heart in total pulmonary bypass, without a pump or reservoir, as an external artificial lung. A 2 sq. M. LEMO proved adequate for a dog weighing 10 kiolgrams. Pulmonary arterial pressure increased 60 per cent of the base-line value at the start of bypass because of transitory LEMO resistance, three times the normal pulmonary resistance; the pressure then returned to the initial value. Systemic arterial pressure dropped to 61 per cent on bypass. The heart did not fail. Cardiac output, central venous pressure, and the electrocardiogram remained unchanged. PO2 at the LEMO outlet was more than 200 mm. Hg. Oxygen transfer was less than 20 ml. per minute per square meter because of hemodilution and hypothermia. Dogs survived if bypass was arrested after 1 hour; if not, they died after an average of 3 hours, 20 minutes on bypass.

Animals↗
PubMed1975

[Resection of pulmonary metastases (author's transl)].

The authors report on a personal series of 27 patients with pulmonary metastases; seventeen were operated, 3 for cure. Nine hundred and eighty six operated cases from the litterature are then analysed yielding the following notions. Where the primary tumor is controlled at the time of metastatic resection, when there is no systemic or mediastinal dissemination, and when the growth of metastases was slow, these secondary resection of lung metastases were followed by a 16 to 63% 5- year survival rate. The authors conclude it is necessary to control the hypothesis that 5 to 10% of operated cancers present a second operative indication for cure: slow growing metastases limited to the lungs.

Carcinoma↗