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P Vallance

Publications and source records attributed to P Vallance.

151 records · Page 9Linked to original sources
PubMedDate not supplied

Endogenous inhibitors of nitric oxide synthesis: how important are they?

In animals and humans, inhibition of nitric oxide (NO) production has widespread effects. Reduced activity of the NO:cyclic GMP pathway has been documented in disease states, including hypertension, diabetes and certain types of renal disease. Inhibitors of NO synthesis occur endogenously, and have been implicated in the regulation of the NO pathway in health and disease. Here we review the possible biological roles of endogenous NO synthase inhibitors, with particular reference to renal disease.

Animals↗
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Hypertension.

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Antihypertensive Agents↗
PubMedDate not supplied

Nitric oxide--from mediator to medicines.

Nitric oxide is involved in a wide range of physiological processes in humans and in animals. It controls vascular tone, acts as a neurotransmitter and neuromodulator in the central and peripheral nervous systems and influences the activity of the immune system. Substances that selectively enhance or inhibit its synthesis or removal and modify its effects, are likely to yield interesting therapeutic agents.

Amino Acid Oxidoreductases↗