Search PubMed⌕ Search

Biomedical subjects

P V Kumar

Publications and source records attributed to P V Kumar.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

Choriocarcinoma metastatic to the breast diagnosed by fine needle aspiration.

Fine needle aspiration (FNA) was used to study nodules in the left breast of a patient with a previous history of uterine choriocarcinoma. The FNA smears contained numerous malignant mononucleated cells and multinucleated giant cells. The cytologic diagnosis was metastatic choriocarcinoma, which was confirmed by histologic study of excised tissue. That diagnosis would have been difficult to make cytologically if the previous history had not been known; the differential diagnosis of multinucleated giant cells in an aspirate from a breast mass is discussed.

Adult↗
PubMedDate not supplied

Fine needle aspiration cytologic findings in pseudolymphoma cutis.

Skin nodules in three patients were sampled by fine needle aspiration. Cytologic study of the aspirated material showed a polymorphic cell population composed of small and large lymphocytes, eosinophils, plasma cells and tingible macrophages. Occasional giant cells and mast cells were also seen. These cytologic features suggested Hodgkin's lymphoma, lymphomatoid papulosis, large-cell non-Hodgkin's lymphoma and regressing atypical histiocytosis. However, because of the lack of typical Reed-Sternberg cells and due to the presence of polymorphic cells with fine chromatin, regular nuclear borders and inconspicuous nucleoli, these cases were diagnosed cytologically as a benign lymphoproliferative disorder, pseudolymphoma cutis. Biopsy of the lesions confirmed the cytologic diagnoses.

Adult↗
PubMedDate not supplied

Prayer nodules fine needle aspiration cytologic findings.

The enlarged prayer nodules from five patients were aspirated for cytologic studies. The fine needle aspiration yielded a cheesy material that showed keratin plaques and hair fragments. The cytologic interpretation of the nodules as multiple epidermoid cysts was confirmed by subsequent histologic study.

Biopsy, Needle↗
PubMedDate not supplied

Cytopathology of alpha chain disease involving the central nervous system and pleura.

Alpha chain disease, a lymphomatous disorder characterized by the synthesis and secretion of an abnormal IgA immunoglobulin devoid of light chains, involves mainly the gastrointestinal tract. This paper presents the cytologic and histologic findings in two cases of alpha chain disease involving the central nervous system and pleura. Most of the cell populations in the cerebrospinal fluid (CSF) and pleural fluid resembled immature plasma cells (immunoblasts); many of these cells were degenerated, with well-preserved plasma cells seen more rarely. While the definitive diagnosis of alpha chain disease depends on immunochemical analysis of serum proteins, cytology can play a role by the identification of malignant cells in CSF and pleural fluid specimens. A positive staining of such cells by the methyl green pyronin reaction may permit the correct diagnosis to be suggested.

Adult↗
PubMedDate not supplied

Cytopathology of peritoneal endometriosis caused by ruptured ovarian cysts.

The cytopathologic features of two cases of peritoneal endometriosis (secondary to ruptured ovarian endometrial cysts) are described. Both patients presented with abdominal distension and tenderness and were clinically thought to have an abdominal tumor. Preoperative cytologic examination of peritoneal fluids gave a diagnosis of endometriosis in both cases. The endometrial tissue was present in the smears as honeycombs, syncytia and tight clusters of both epithelial and stromal cells. Subsequent surgery confirmed the cytodiagnosis in both cases. These cases emphasize the need to include endometriosis in the differential diagnosis of peritoneal effusions, especially in women.

Adult↗
PubMedDate not supplied

Fine needle aspiration cytology of localized Leishmania lymphadenitis.

Leishmania lymphadenitis, an uncommon cause of lymphadenopathy, is usually diagnosed by surgical biopsy performed because of suspicion of lymphoma. The cytopathologic features of this disease do not appear to have been previously described. This paper describes the findings in seven cases of Leishmania lymphadenitis diagnosed by fine needle aspiration (FNA) cytology. The identification of Leishman-Donovan bodies in epithelioid cells in the aspirates led to the cytologic diagnosis of Leishmania lymphadenitis, which was histologically confirmed in all cases. Since this disease is self-limiting and requires no treatment, FNA diagnosis is especially useful in that the patient can be spared more invasive diagnostic techniques.

Adult↗
PubMedDate not supplied

Diagnosis of intestinal malakoplakia by fine needle aspiration cytology.

Two cases of intestinal malakoplakia were diagnosed by fine needle aspiration (FNA) cytology. Clinically, these cases were mistaken for a lymphoma and a tuberculosis. Percutaneous abdominal FNA material showed numerous macrophages with the characteristic Michaelis-Gutmann bodies. These bodies were easily identified both inside and outside the macrophages in the smears.

Biopsy, Needle↗
PubMedDate not supplied

Fine needle aspiration cytologic diagnosis of ganglioneuroblastoma.

Two children with ganglioneuroblastomas in different locations underwent fine needle aspiration (FNA). Clinically, the tumor in the presacral area was diagnosed as a benign teratoma and the retroperitoneal tumor as a neuroblastoma. Both tumors were correctly diagnosed preoperatively as ganglioneuroblastomas by FNA cytology. The smears showed the characteristic Homer-Wright rosettes, ganglion cells and fibrillar material.

Biopsy, Needle↗
PubMedDate not supplied

Splenic hamartoma. A diagnostic problem on fine needle aspiration cytology.

Between 1980 and 1992, four splenic hamartomas from three patients were aspirated for cytologic diagnosis. Two patients were female and one male, with two lesions. All were seen because of hematologic problems, such as anemia and pancytopenia. Routine bone marrow study revealed normal to hypercellular marrow. Abdominal sonography revealed hypoechoic masses in the spleen. In all cases the clinical diagnosis of a malignant lymphoma was established. The smears of aspirated material showed many small and large clusters composed of large, abnormal cells that were diagnosed as metastatic tumors. Since no primary tumor sites were detected, the patients underwent splenectomy for a definitive diagnosis. Histologically the splenic masses were diagnosed as hamartomas. The source of the abnormal cells could have been endothelial cells or hematologic precursor cells, such as erythroblasts or atypical lymphocytes. The hematologic abnormalities disappeared after removal of the spleen.

Adult↗
PubMedDate not supplied

Testicular embryonal rhabdomyosarcoma diagnosed by fine needle aspiration cytology. A report of two cases.

During a 12-year period, 1980-1992, two cases of testicular embryonal rhabdomyosarcoma were diagnosed by fine needle aspiration cytology at the Shiraz University Hospitals. The smears revealed various types of cells including spindle cells, strap cells, rhabdomyoblasts, round cells and tadpole cells with a high nuclear/cytoplasmic ratio. Cross-striations were noticed in the cytoplasm at higher magnification under oil immersion. The cytologic diagnoses of embryonal rhabdomyosarcomas were confirmed on histologic sections.

Biopsy, Needle↗
PubMedDate not supplied

Fine needle aspiration cytologic findings in malignant small cell tumor of the thoracopulmonary region (Askin tumor).

From 1980 to 1992, five cases of Askin tumor were diagnosed by fine needle aspiration cytology at the Shiraz University Hospitals, Namazi, Faghihi and Beheshti, Iran. All patients were female, their ages ranging between 15 and 22 years. Three of them had a mass on the right side and two on the left side of the chest. Chest roentgenography revealed no bone involvement. Two tumors involved the lungs and pleura. Urinary catecholamine levels were within normal limits. The fine needle aspiration smears revealed many small, round malignant cells with indistinct cytoplasm, a high nuclear/cytoplasmic ratio and prominent, multiple nucleoli. Homer-Wright rosettes were seen frequently. The cells were often arranged in rows simulating rouleaux formation. They were positively stained by periodic acid-Schiff stain. The histologic sections confirmed the cytologic diagnosis of Askin tumor. Four of the patients died within 7-11 months after treatment began.

Adolescent↗
PubMedDate not supplied

Fine needle aspiration findings in generalized post-Calmette-Guérin bacillus lymphadenitis presenting as an abdominal mass.

Generalized lymphadenopathy with an abdominal mass following a Calmette-Guérin bacillus vaccination is a rare complication and often confused clinically with malignant neoplasms, such as lymphoma and leukemia. Smears from lymph nodes and abdominal masses reveal numerous macrophages with streaked or wrinkled cytoplasm. These cells closely resemble Gaucher cells. The streaked appearance of the cytoplasm is due to the presence of numerous acid-fast bacilli in the cytoplasm.

Abdominal Neoplasms↗
PubMedDate not supplied

Soft tissue chloroma diagnosed by fine needle aspiration cytology. A case report.

A case of soft tissue chloroma diagnosed by fine needle aspiration cytology is reported. The smears revealed numerous large, granular promyelocytes, rare eosinophils and metamyelocytes. The promyelocytes showed many Auer rods (faggot cells). The histologic sections of the excised tumor confirmed the cytologic diagnosis of chloroma. The patient developed leukemia seven months after excision of the chloroma.

Adult↗